{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T05:23:27Z","timestamp":1738473807410,"version":"3.35.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:p>The severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) has been changing continuously. This study was conducted to evaluate clinical characteristics, Molecular analysis &amp; Genomic sequencing of SARS-Cov-2 during second wave in Raigarh district, Chhattisgarh, India. This study evaluated 13402 breakthrough cases of COVID -19. The laboratory obtained the nasopharyngeal\/oropharyngeal swabs (NPS\/OPS) of SARS-CoV-2 patients who tested positive by real-time RT-PCR, together with clinical and demographic information. Next generation sequencing (NGS) was used to sequence these clinical specimens in order to identify nucleotide changes in the SARS-CoV-2 genome from these strains. In the study population, variants of concern (VOCs) and other variations were looked for. Clinical severity was mild in 47.05% patients with mutational variants; while 52.94% patient's clinical severity was moderate. Delta (B.1.617.2) was the most common VOC detected. Among non VOC variants, AY.4 and AY.12 variants were most commonly detected. Envelope (E) gene and RNA-dependent RNA polymerase (RdRp) mutation were most commonly observed.<\/jats:p>","DOI":"10.6026\/9732063002001059","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:31:58Z","timestamp":1738402318000},"page":"1059-1064","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characterization, molecular and genomic sequencing analysis of SARS-Cov-2 during second wave at Raigarh, Chhattisgarh, India"],"prefix":"10.6026","volume":"20","author":[{"name":"Department of Microbiology, Government Medical College, Mahasamund, Chhattisgarh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anubha","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuniti","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Microbiology, BRLSABVM Medical College, Rajnandgaon, Chhattisgarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Baghel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Community Medicine, Government Medical College, Mahasamund, Chhattisgarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Microbiology, LSLAMG Medical College, Raigarh, Chhattisgarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Kujur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Scientific Officer (Biology), State Forensic Science Laboratory, Raipur, Chhattisgarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2024,9,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:32:04Z","timestamp":1738402324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/020\/9732063002001059.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,30]]},"published-print":{"date-parts":[[2024,9,30]]}},"URL":"https:\/\/doi.org\/10.6026\/9732063002001059","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}