{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:25:39Z","timestamp":1761402339319,"version":"3.35.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:p>Oral submucous fibrosis (OSMF) is a potentially cancerous disorder that affects the oral mucosa and causes a range of symptoms and limitations in function. Assessing the function of oral alpha lipoic acid (AL-A) as a therapy for OSMF is, therefore, intriguing. Fifty patients with OSMF symptoms were evaluated both before and after treatment. They were split into two groups: group A, which served as the control, received 1 ml SI of thioacetamide (TAA) and 1500 IU of hyaluronidase (HYAL) weekly along with the oral antioxidant \u03b1-lipoic acid for three months. Group B, which served as the case study, also received 3 months of SI of TAA and HYAL. Patients in group B were recalled for a clinical examination using a vernier caliper (VC), and visual analog scale (VAS) and fibrous bands (FB) were assessed at the 1st, 3rd, and 6th month. We discovered that controls had a comparable distribution pattern across visits when compared to the case. Treatment with AL-A in conjunction with IL-I of TAA and HYAL significantly reduced the severity of symptoms, especially Burning Sensation (BS) and mouth opening (MO), in the case group over time, as previously determined.<\/jats:p>","DOI":"10.6026\/9732063002001401","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T07:31:53Z","timestamp":1738481513000},"page":"1401-1404","source":"Crossref","is-referenced-by-count":1,"title":["Effect of oral alpha lipoic acid in treatment of OSMF"],"prefix":"10.6026","volume":"20","author":[{"name":"Department of ENT, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AK Shafeem","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of ENT, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay D.","family":"Havle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, Krishna Institute of Medical Sciences, Karad - 415 539, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2024,10,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T07:32:02Z","timestamp":1738481522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/020\/9732063002001401.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,31]]},"published-print":{"date-parts":[[2024,10,31]]}},"URL":"https:\/\/doi.org\/10.6026\/9732063002001401","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}