{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:27:51Z","timestamp":1779910071082,"version":"3.53.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:p>The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the \u03b17-nicotinic acetylcholine receptor (\u03b17-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)-3 chaperone protein. The point is made in this writing that therapeutic stimulation of the non-neuronal cholinergic system via, for instance, transcutaneous vagal stimulation, pharmaco-therapeutic activation of \u03b17-nAChR\/RIC-3, or stimulation of the pathway by other means, including microRNA treatment interventions could down-regulate states of inflammation such as the cytokines storm and chronic systemic inflammation in aging - viz, inflammAging. It is possible and even likely that controlling inflammAging by intervening on the non neuronal cholinergic system (NNCS) will be beneficial to a wide range of aging-related diseases, from type 2 diabetes and obesity to periodontal disease.<\/jats:p>","DOI":"10.6026\/973206300210571","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:30:27Z","timestamp":1744119027000},"page":"571-574","source":"Crossref","is-referenced-by-count":3,"title":["Regulation of inflammAging"],"prefix":"10.6026","volume":"21","author":[{"name":"Dental Group of Sherman Oaks, Sherman Oaks, CA 91403 (www.oliviacajulisdds.com)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiappelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"UCLA Center for the Health Sciences, Los Angeles, CA 90095","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Fotovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Boston University, Boston, MA 02118","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Khakshooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Valley Hospital Medical Center, Las Vegas, NV 89106","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwadayo","family":"Oluwadara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Oluwadara Dental Corporation, 9612 East Foothill Blvd, Suite 100, Rancho Cucamonga, CA 91730","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaden","family":"Penhaskashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Division of West Valley Dental Implant Center, Encino, CA 91316","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2025,4,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:30:28Z","timestamp":1744119028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300210571.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,4,30]]},"published-print":{"date-parts":[[2025,4,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300210571","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}