{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T14:40:07Z","timestamp":1751726407305,"version":"3.41.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,5,31]]},"abstract":"<jats:p>Periodontal and microbiological characteristic among cleft lip and\/or palate patients undergoing fixed orthodontic treatment is of interest. Plaque and saliva samples showed high prevalence of Streptococcus mutans (83%), Lactobacillus spp. (67%), and Porphyromonas gingivalis (55%). In vitro analysis showed significantly greater biofilm formation on stainless steel brackets compared to ceramic brackets (p &lt; 0.01), confirmed by SEM imaging. Elevated levels of IL-1\u03b2 and MMP-8 in gingival crevicular fluid were positively correlated with microbial load (r = 0.72, p &lt; 0.05). Thus, the influence of bracket material on biofilm formation and local inflammatory response is shown.<\/jats:p>","DOI":"10.6026\/973206300211286","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T14:17:58Z","timestamp":1751725078000},"page":"1286-1289","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal and microbiological evaluation in cleft lip\/palate patients undergoing orthodontic treatment: An in vitro study"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Periodontology, Teerthanker Mahaveer Dental and Research Centre, Teerthanker Mahaveer University, Moradabad, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Statistics, Sri Venkateswara College, University of Delhi, Benito Juarez Road, Dhaula Kuan, New Delhi, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibhuti","family":"Madhad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, Siddhpur Dental College and Hospital, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, Eklavya Dental College and Hospital, Jaipur, Rajasthan, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Conservative Dentistry and endodontics, Kalinga Institute of Dental Sciences, KIIT deemed to be University, Bhubaneswar, Odisha, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,5,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T14:17:59Z","timestamp":1751725079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300211286.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,5,31]]},"published-print":{"date-parts":[[2025,5,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300211286","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,31]]}}}