{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:27:24Z","timestamp":1783369644816,"version":"3.54.6"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:p>Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p &lt; 0.01), such that patients with low levels of vitamin (&lt;20 ng\/mL) had higher frequencies of relapse.<\/jats:p>","DOI":"10.6026\/973206300211639","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:31:54Z","timestamp":1751466714000},"page":"1639-1642","source":"Crossref","is-referenced-by-count":2,"title":["Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Internal Medicine, University Hospital of Wales (UHW), Heath Park Way, Cardiff, CF14 4XW, UK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurram","family":"Lokesh Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekara","family":"Rohan Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka 562110, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadas","family":"Ashok Nimmakanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameshbabu","family":"Sushmitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thambi","family":"Harinishri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgery, Madras Medical College, Chennai, Tamil Nadu, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chammanam","family":"Sarita Sunil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Medicine, JSS Academy of Higher Education and Research, Mysuru \u2013 570 015, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Karrar Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Medicine, University of Warith Al-Anbiyaa, Karbala Governorate, Iraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2025,6,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:31:57Z","timestamp":1751466717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300211639.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,6,30]]},"published-print":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300211639","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}