{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:17:18Z","timestamp":1775744238089,"version":"3.50.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:p>The condition of periodontal diseases that results from oral dysbiosis-related inflammation poses crucial public health concerns. Therefore, it is of interest to assess an in-situ gel made with Drynaria rhizome extract for local drug application in periodontal care. The Drynaria in-situ gel has desirable clinical properties because its combination of Sodium Tripolyphosphate (STPP), Poloxamer 407, Acetic Acid and Chitosan produces temperature-sensitive features and viscosity stability. Studies under laboratory conditions proved both the uniformity and stability of the gel. The tested Drynaria gel emerges as a promising choice for local drug delivery in periodontal healthcare and researchers need to conduct additional clinical trials to prove its performance in real-world conditions.<\/jats:p>","DOI":"10.6026\/973206300212006","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T06:41:26Z","timestamp":1754894486000},"page":"2006-2011","source":"Crossref","is-referenced-by-count":1,"title":["In vitro characterization of drynaria in-situ gel: A novel approach to periodontal disease management"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Periodontology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal Pati","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragati","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakshi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Unit of Oral Medicine and Radiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Choubey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontics and Implantology, Hitkarini Dental College and Hospital, Jabalpur-482001, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,7,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T06:41:27Z","timestamp":1754894487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300212006.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,7,31]]},"published-print":{"date-parts":[[2025,7,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300212006","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}