{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:05:55Z","timestamp":1757621155677,"version":"3.44.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:p>Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM) and genetic variants like RAGE -374T\/A may influence disease susceptibility. Therefore, it is of interest to analyze the association between RAGE -374T\/A polymorphism and DN in T2DM patients from Kolar, Karnataka. Genotyping was done by PCR-RFLP and clinical parameters were compared. No significant association was found between the polymorphism and DN (p &gt; 0.05), though DN patients showed elevated HbA1c, microalbuminuria and dyslipidemia. These findings suggest metabolic factors, rather than this specific RAGE variant, are more strongly linked to DN risk in this population.<\/jats:p>","DOI":"10.6026\/973206300212288","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:02:22Z","timestamp":1757332942000},"page":"2288-2292","source":"Crossref","is-referenced-by-count":0,"title":["Rage gene -374T\/A polymorphism in South Indian diabetic nephropathy"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, Vinayaka Misson's Research Foundation (DU), Salem, Tamilnadu, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh Babu","family":"Murikipudi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmiprabha","family":"S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, KMMC Medical College and Hospital, Muttom, Kanyakumari., St. Joseph University, Bengaluru, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravallika","family":"P","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology, Shridevi institute of medical sciences and research hospital Tumkur, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnudhali","family":"D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, Vinayaka Misson's Research Foundation (DU), Salem, Tamilnadu, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangabashyam","family":"S.R.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General medicine, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangarajan","family":"R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, Government Mohan Kumaramangalam Medical College Hospital, Shevapet, Salem, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,8,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:02:23Z","timestamp":1757332943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300212288.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,8,31]]},"published-print":{"date-parts":[[2025,8,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300212288","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"type":"print","value":"0973-8894"},{"type":"electronic","value":"0973-2063"}],"subject":[],"published":{"date-parts":[[2025,8,31]]}}}