{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:22:06Z","timestamp":1793298126452,"version":"4.5.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:p>Psoriasis is a chronic immune-mediated skin disorder in which systemic inflammation and cytokine dysregulation play central roles. Identifying correlations between cytokine levels and disease severity may aid in establishing reliable biomarkers. In this cross-sectional study, 60 psoriasis patients and 30 healthy controls were evaluated; PASI scores were recorded and serum TNF-\u03b1, IL-6 and IL-17 levels was measured using ELISA. All three cytokines were significantly elevated in patients and showed strong positive correlations with PASI scores. Elevated TNF-\u03b1, IL-6 and IL-17 may serve as biomarkers of disease activity and potential therapeutic targets in psoriasis management.<\/jats:p>","DOI":"10.6026\/973206300212803","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T03:02:53Z","timestamp":1757473373000},"page":"2803-2806","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of serum cytokine levels with disease severity in psoriasis: A physiological insight into inflammatory markers"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Dermatology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghav","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devpriya","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Medicine, Bundelkhand Medical College, Sagar, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Psychiatry, Bundelkhand Medical College, Sagar, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2025,8,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T03:02:55Z","timestamp":1757473375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300212803.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,8,31]]},"published-print":{"date-parts":[[2025,8,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300212803","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]}}}