{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:16:21Z","timestamp":1793225781812,"version":"4.5.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in obese individuals, and gut microbiota dysbiosis is increasingly recognized as a major contributor to its pathogenesis. In this cross-sectional study of 80 obese participants (40 NAFLD and 40 controls), 16S rRNA sequencing revealed significantly reduced microbial diversity in NAFLD patients (Shannon index 2.9 vs. 3.6; p=0.001), with increased Firmicutes, Enterobacteriaceae, and Ruminococcus, and decreased Bacteroidetes. These patients also showed elevated liver enzymes (ALT, AST) and inflammatory markers (TNF-\u03b1, IL-6). A strong correlation was observed between gut dysbiosis and hepatic steatosis (r=0.72; p&lt;0.001), highlighting the potential of microbiota modulation as a therapeutic strategy for NAFLD.<\/jats:p>","DOI":"10.6026\/973206300212868","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:42:33Z","timestamp":1758199353000},"page":"2868-2871","source":"Crossref","is-referenced-by-count":1,"title":["Role of gut microbiota dysbiosis in the pathogenesis of non-alcoholic fatty liver disease among obese individuals"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Internal Medicine, Columbus Regional Hospital, Columbus, Indiana, United States of America","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Krishna Prasad","family":"Vudathaneni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha Bharathi","family":"Nadella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Columbus Regional Hospital, Columbus, Indiana, United States of America","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Mogallapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine, West Virginia University, Morgantown, United States of America","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalikrishna Varaprasad","family":"Movva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anaesthesiology, Anaesthetics, Principal House Officer, Mackay Base Hospital, Mackay, Queensland, Australia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanarayana","family":"Boyapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Periodontology, Sibar Institute of Dental Sciences, Takkellapadu, Guntur andhra Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2025,8,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:42:35Z","timestamp":1758199355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300212868.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,8,31]]},"published-print":{"date-parts":[[2025,8,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300212868","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]}}}