{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:58:54Z","timestamp":1762412334306,"version":"build-2065373602"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:p>Natural sweetening agents have recently gained attention as potential alternatives to refined sugar, owing to their possible non-cariogenic or even protective effects against dental caries. Therefore, it is of interest to evaluate the effect of natural sweetening agents on salivary pH levels in children visiting a dental hospital in North India. This current in vivo study was conducted among 140 children who were randomly allocated to four groups (n = 35 each): Group A (xylitol), Group B (maple syrup), Group C (date sugar) and Group D (distilled water, control). Saliva was collected at baseline, 0, 15 and 30 minutes post-rinsing and pH was assessed using indicator strips. All natural sweeteners significantly increased salivary pH (p &lt; 0.05), peaking at 15 minutes. Xylitol showed the highest mean pH at 30 minutes (7.40 \u00b1 0.60), while no significant changes occurred in the control group. Xylitol, maple syrup and date sugar positively modulate salivary pH, with xylitol showing the greatest effect.<\/jats:p>","DOI":"10.6026\/973206300213917","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:52:38Z","timestamp":1762411958000},"page":"3917-3920","source":"Crossref","is-referenced-by-count":0,"title":["A comparative in vivo study of natural sweetening agents and their effect on salivary pH levels among children visiting a dental hospital in North India"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Paediatric & Preventive Dentistry, Career Post Graduate Institute Of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep Kumar","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shambhavi","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Irfaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Paediatric & Preventive Dentistry, Career Post Graduate Institute Of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revathy","family":"Seetharaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Orthodontics and Dentofacial Orthopaedics, Vinayaka Mission's Sankarachariyar Dental College, A Constituent College of Vinayaka Mission's Research Foundation (Deemed to be University), Ariyanoor, Tamilnadu, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Paediatric & Preventive Dentistry, Career Post Graduate Institute Of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,10,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:52:47Z","timestamp":1762411967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300213917.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,31]]},"published-print":{"date-parts":[[2025,10,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300213917","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"type":"print","value":"0973-8894"},{"type":"electronic","value":"0973-2063"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}