{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:05:22Z","timestamp":1764245122964,"version":"3.46.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:p>The variability in surgical stress response among patients undergoing elective abdominal surgeries remains inadequately understood, particularly in relation to genetic polymorphisms influencing drug metabolism and pain modulation. Hence, this study explored the association between key pharmacogenetic variants (CYP2D6, CYP3A4, OPRM1, COMT) and biomarkers of surgical stress response. A total of 240 patients were evaluated, with half receiving pharmacogenomic-guided perioperative management. Significant differences were observed in IL-6 levels, opioid requirements and complication rates between genotypic groups. Pharmacogenomic-guided therapy effectively reduced postoperative complications and improved recovery, underscoring its potential for personalized surgical care.<\/jats:p>","DOI":"10.6026\/973206300214005","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:00:49Z","timestamp":1764244849000},"page":"4005-4010","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacogenomics of surgical stress response in elective abdominal surgeries"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Medicine, B.J. Medical College, Ahmedabad, Gujarat, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tirth Hareshkumar","family":"Vyas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahi Jayeshbhai","family":"Khiloshiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Casualty, GMERS Medical College and Civil Hospital, Junagadh, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha Jayantilal","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pathology, Dr. N.D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya Girishbhai","family":"Kaneria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medicine, GMERS Medical College and Civil Hospital, Junagadh, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha Bhaumik","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Public Health, Long Island University, USA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,11,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:00:50Z","timestamp":1764244850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214005.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,15]]},"published-print":{"date-parts":[[2025,11,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214005","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]}}}