{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:05:22Z","timestamp":1764245122720,"version":"3.46.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:p>It is essential to detect clinically significant prostate cancer (csPCa) in an early and precise manner. However, there are challenges given that the usual TRUS-guided biopsy may leave tumors undiagnosed, or only detect indolent disease. In this prospective cohort study of 200 patients, we compared the diagnostic accuracy of multiparametric MRI (mpMRI) with TRUS-guided biopsy. The study found better sensitivity (91% vs 68%) and specificity (76% vs 60%) than TRUS biopsy, and identified 22% more clinically significant cancers than TRUS biopsies. In addition, mpMRI showed better positive predictive value and negative predictive value than TRUS-guided biopsy; this suggests general advantage in diagnostic accuracy and performance for mpMRI. Data shows, there is support for mpMRI having improved efficacy as a method of detecting clinically significant prostate cancer early compared to TRUS-guided biopsy.<\/jats:p>","DOI":"10.6026\/973206300214015","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:00:49Z","timestamp":1764244849000},"page":"4015-4019","source":"Crossref","is-referenced-by-count":0,"title":["Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Emergency Medicine, University Hospitals of Morecambe Bay, NHS Trust, United Kingdom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Karunakaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holebasu","family":"Ballur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Radio-Diagnosis, KLE Jagadguru Gangadhar Mahaswamigalu Moorsavirmath Medical College, Hubli, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana Abarnadevi","family":"Karthikeyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of HPB Surgery, Kings College Hospital, London, England, United Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satya Sudhakara","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Trauma and Orthopaedics, Lancashire Teaching Hospitals NHS Foundation Trust, United Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kausalya","family":"Perumalsamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatrics, Resident Medicla Officer, Kauvery Hospital, Tirunelveli, Tamil Nadu, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anannya","family":"Vaibhavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology, RML hospital, Lucknow, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,11,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T12:00:50Z","timestamp":1764244850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214015.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,15]]},"published-print":{"date-parts":[[2025,11,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214015","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]}}}