{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:43:54Z","timestamp":1774935834428,"version":"3.50.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:p>Medication-related osteonecrosis of the jaw (MRONJ) remains a significant clinical challenge due to its complex etiology and variable response to treatment. This prospective observational study evaluated the effectiveness of current management protocols in 130 patients receiving antiresorptive or antiangiogenic therapies. Patients were assessed clinically and radiographically and treated according to standardized stage-specific guidelines. Combined conservative and surgical interventions achieved better healing rates, symptom control, and improved quality of life over 12 months. These findings support ongoing refinement of stage-based MRONJ protocols to optimize therapeutic outcomes and patient care.<\/jats:p>","DOI":"10.6026\/973206300214144","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:55:06Z","timestamp":1764251706000},"page":"4144-4147","source":"Crossref","is-referenced-by-count":1,"title":["Managing medication-related osteonecrosis of jaw: a prospective observational study"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Oral Surgery, Rajasthan Dental College, Jaipur, Rajasthan, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra Kumar","family":"Dadarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timbadiya","family":"Vijaykumar Mansukhbhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timbadiya","family":"Vijaykumar Mansukhbhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral Pathology and Microbiology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishad","family":"Gawali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Public Health Dentistry, Hazaribag College of Dental Sciences and Hospitals, Hazaribagh, Jharkhand, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep Kumar","family":"Dohare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Community Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumi","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, Rajasthan Dental College and Hospital, Jaipur, Rajasthan, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Kharat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Prosthodontics, Dr RR Kambe Dental College and Hospital, Akola, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,11,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:55:07Z","timestamp":1764251707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214144.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,15]]},"published-print":{"date-parts":[[2025,11,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214144","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,15]]}}}