{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:04:34Z","timestamp":1782727474201,"version":"3.54.5"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>Rheumatoid arthritis (RA) is a long-term autoimmune disease that needs to be diagnosed as soon as possible in order to achieve maximum treatment results. Although rheumatoid factor (RF) has been a conventional serologic test, the anti-cyclic citrullinated peptide (anti-CCP) antibodies are now considered a more specific diagnostic test. Therefore, it is of interest to determine the diagnostics performance of RF and anti-CCP antibody tests in suspected RA patients in a tertiary care hospital. One hundred and eighty participants will be recruited, that is, 120 participants diagnosed with RA clinically (according to the 2010 ACR\/EULAR definitions) and 60 age-matched controls. RF in serum samples was studied by nephelometry and the anti-CCP antibodies through enzyme-linked immunosorbent assay (ELISA). Anti-CCP antibodies were more specific (96.7% vs. RF, 78.3%), whereas the sensitivity was also similar (81.7% vs. 75.0% respectively). Anti-CCP (96.1) had a better positive predictive value than RF (85.7%). The sensitivity (88.3%) and specificity (95.0%) with combined testing were improved. Anti-CCP was found to have significant correlations with disease activities and radiological erosions. Data shows uphold anti-CCP antibodies as a better diagnostic tool than RF in Diagnosing RA and the combination of the two tests provides the best diagnostic value in the early stages of the disease and prognostication.<\/jats:p>","DOI":"10.6026\/973206300214420","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:47:08Z","timestamp":1768222028000},"page":"4420-4424","source":"Crossref","is-referenced-by-count":1,"title":["Effect of RF and Anti-CCP antibody for Rheumatoid Arthritis diagnosis: A comparative study"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of General Medicine, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Dubepuria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Singh","family":"Mahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Medicine, Government Medical College, Sheopur, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Medicine, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishtha","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General Medicine, R.D Gardi Medical College, Ujjain, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:47:13Z","timestamp":1768222033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214420.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214420","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}