{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:12:10Z","timestamp":1768234330281,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>There is a high risk of vertical and horizontal bone resorption in the peri-implant gap following immediate implant placement after non-molar tooth extraction, which compromises implant stability, hard\/soft tissue preservation, and esthetic outcomes. The present study was a randomized controlled clinical trial included 40 patients requiring a single non-molar tooth extraction and immediate implant placement. Patients were randomly allocated into two equal groups (n=20). In the Test group, the peri-implant gap was filled with a composite of PRF and DFDBA. In the Control group, no grafting material was placed. The primary outcome was vertical bone level (VBL) change at 6 months, measured on standardized radiographs. Secondary outcomes included horizontal bone thickness changes measured on CBCT, implant stability quotient (ISQ) at baseline and 3 months and Pink Esthetic Score (PES) at 6 months. Independent t-tests were used for statistical analysis (\u03b1=0.05). The adjunctive use of a composite PRF and DFDBA graft in immediate implant placement sockets significantly improves the preservation of peri-implant hard and soft tissues, enhances secondary implant stability and leads to superior esthetic outcomes compared to no grafting.<\/jats:p>","DOI":"10.6026\/973206300214430","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:47:08Z","timestamp":1768222028000},"page":"4430-4434","source":"Crossref","is-referenced-by-count":0,"title":["Immediate implant placement with and without platelet-rich fibrin and decalcified freeze-dried bone graft"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Periodontology and Implantology, Consultant, P.N. Singhdeo Dental Clinic, Sambalpur, Odisha, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akriti","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"M. Alwaisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology and Implantology, Gulf Medical University, Ajman, Aljurf 1, UAE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awaiz","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatric Dentistry, Consultant, Dr. Awaiz's Dental Planet, Bidar, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza","family":"A. Abushama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Preventive Dental Sciences (Periodontology) College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Yasir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology and Implantology, Gulf Medical University, Ajman, Aljurf 1, UAE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnaaz","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology and Implantology, Al Badar Rural Dental College and Hospital, Kalaburagi, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kafeel Ahmed","family":"Md","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology and Implantology, MNR Dental College and Hospital, Sangareddy, Hyderabad, Telangana, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:47:13Z","timestamp":1768222033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214430.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214430","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}