{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:18:01Z","timestamp":1768303081365,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>The diagnostic performance of Adenosine Deaminase (ADA) and Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) in diagnosing tubercular pleural effusion (TPE) is of interest. Hence, a study was conducted over 18 months at LN Medical College and JK Hospital, Bhopal. The study involved 108 adult patients with TPE. Data shows that CBNAAT, although highly specific, had limited sensitivity, while ADA \u226540 IU\/L demonstrated strong sensitivity. ADA levels were significantly higher in CBNAAT-positive participants, suggesting that combining both tests enhances diagnostic accuracy. This approach can help reduce the need for invasive procedures and improve timely treatment, especially in resource-limited settings. We show the importance of using ADA and CBNAAT together in the diagnosis of TPE.<\/jats:p>","DOI":"10.6026\/973206300214484","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:25:07Z","timestamp":1768278307000},"page":"4484-4487","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic utility of ADA and CBNAAT in tubercular pleural effusion"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Pulmonary Medicine, L N Medical College & J K Hospital, Bhopal, Madhya Pradesh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patel Ronak Kumar","family":"N","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Soni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pulmonary Medicine, BirsaMunda Government Medical College, Shahdol, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darshi","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pulmonary Medicine, L N Medical College& J K Hospital, Bhopal, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, BirsaMunda Government Medical College Shahdol, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Community Medicine,V.K.S. Government Medical College, Neemuch, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:25:10Z","timestamp":1768278310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214484.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214484","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}