{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:16:07Z","timestamp":1768338967450,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>Chronic periodontitis in patients with type 2 diabetes mellitus (T2DM) requires reliable biomarkers for early detection and monitoring. Therefore, it is of interest to evaluate serum and salivary alkaline phosphatase (ALP) levels in 90 participants divided into healthy controls, diabetics with healthy periodontium and diabetics with chronic periodontitis. Salivary and serum ALP levels increased progressively across the groups and were significantly highest in diabetics with periodontitis (p &lt; 0.001). Strong correlations were observed between salivary ALP, serum ALP and periodontal parameters such as probing depth and clinical attachment loss. Salivary ALP shows strong potential as a non-invasive biomarker for periodontal tissue destruction in diabetic patients.<\/jats:p>","DOI":"10.6026\/973206300214559","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:42:36Z","timestamp":1768315356000},"page":"4559-4563","source":"Crossref","is-referenced-by-count":0,"title":["Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Periodontology, Gujarat University, Ahmedabad, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinjal","family":"Desai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, AMC Dental College and Hospital, Khokhara, Ahmedabad, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Nagrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of periodontology & Implantology, Siddhpur Dental College and Hospital, Siddhpur, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral & Maxillofacial Pathology, Siddhpur Dental College and Hospital, Siddhpur - 384151 Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avani","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral & Maxillofacial Pathology and Oral Microbiology, Narsinhbhai Patel Dental College and Hospital, Visnagar Sankalchand Patel University, Visnagar, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Gohil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Periodontology, Founder and chief dentist at Family Dental Clinic, Olpad, Surat, Surat - 395007, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:42:38Z","timestamp":1768315358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214559.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214559","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}