{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:30:44Z","timestamp":1768350644956,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>The relationship between splenomegaly and cytopenias in myeloproliferative disorders (MPDs) remains poorly defined despite its clinical importance. This analytical cohort study evaluated 124 patients with MPDs, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, to characterize associations between splenic enlargement and hematologic abnormalities. Splenomegaly was present in 68.5% of patients and showed significant correlations with anemia and thrombocytopenia. Individuals with massive splenomegaly demonstrated greater symptom burden and more pronounced pancytopenia. These findings suggest that splenic size may serve as an important indicator of disease severity and may guide early therapeutic decision-making in MPD management.<\/jats:p>","DOI":"10.6026\/973206300214678","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:20:41Z","timestamp":1768324841000},"page":"4678-4681","source":"Crossref","is-referenced-by-count":0,"title":["Analytical cohort study on splenomegaly and cytopenias in myeloproliferative disorders"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Critcal Care, Aster Hospital, Muhaisnah, Dubai, UAE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarvodayai","family":"Sinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu Poovathinkal","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, ESIC Hospital, Udyogamandal, Ernakulam, Kerala, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya Unnikrishnan","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, Altnagelvin Hospital, Western Health and Social Care Trust, Northern Ireland, UK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achyuth Prasad","family":"Jakka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, Government Medical College, Anantapuramu andhra Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya Palayapadi","family":"Chandrasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, Sree Balaji Medical College and Hospital, Chrompet, Chennai, Tamil Nadu, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:20:48Z","timestamp":1768324848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214678.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214678","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}