{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:04:17Z","timestamp":1768377857955,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>We conducted a prospective cohort study of 1,200 pregnant women recruited in early first trimester to evaluate the impact of thyroid autoantibodies (TPOAb and\/or TGAb) on maternal and neonatal outcomes. Overall, 18.2% were antibody-positive. Compared with antibody-negative women, those with thyroid autoimmunity had significantly higher risks of pregnancy-induced hypertension (12.6% vs 7.9%), gestational diabetes (15.3% vs 10.2%) and neonatal intensive care unit admission (11.2% vs 6.5%). Adjusted logistic regression confirmed independent associations after controlling for maternal age, BMI, parity and TSH levels. Neonates born to antibody-positive mothers had lower mean birth weight (2980 \u0105 420 g vs 3125 \u0105 395 g, p=0.02) and higher risk of small-for-gestational age (8.7% vs 4.9%). Thus, we show that thyroid autoantibodies, even in euthyroid women, are associated with adverse pregnancy outcomes and justify closer monitoring during antenatal care.<\/jats:p>","DOI":"10.6026\/973206300214749","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:04:44Z","timestamp":1768359884000},"page":"4749-4752","source":"Crossref","is-referenced-by-count":0,"title":["Impact of thyroid autoantibodies on pregnancy: A prospective cohort study"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Obstetrics and Gynaecology, Saraswati Medical College, Atal Bihari Vajpayee Medical University, Unnao, Lucknow, Uttar Pradesh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashika","family":"Sheetal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallikarjun","family":"Samala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Piedmont Rockdale Hospital & Family, First Primary Clinic, Atlanta, GA, USA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heena","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Managutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akriti","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral medicine and radiology, Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:05:09Z","timestamp":1768359909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214749.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214749","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}