{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:39:48Z","timestamp":1768379988003,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>Persistent endodontic infections remain difficult to eradicate due to the resistance of biofilm-forming pathogens to conventional medicaments. Therefore, it is of interest to evaluate Ag-ZnO hybrid nanoparticles synthesized via a sol-gel method for their antimicrobial efficacy against E. faecalis, C. albicans and A. israelii. The nanoparticles showed strong antibacterial activity, including large inhibition zones, low MIC values (12.5\u201325 \u03bcg\/mL) and 87.3% biofilm suppression at 100 \u03bcg\/mL. Cytotoxicity testing confirmed &gt;80% fibroblast viability at therapeutic concentrations. Ag-ZnO NPs demonstrated potent antimicrobial performance with acceptable biocompatibility, supporting their potential as an advanced intracanal medicament.<\/jats:p>","DOI":"10.6026\/973206300214807","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:27:36Z","timestamp":1768361256000},"page":"4807-4811","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial activity of novel nanoparticles against persistent endodontic pathogens"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT Deemed to be university, Bhubaneswar, Odisha, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koustav","family":"Dhara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Batra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Conservative dentistry and Endodontics, National Dental College and Hospital Derabassi , Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Nagabhushan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Oral Pathologist, Pandits dental care, 15th Cross LIC colony srirampura 2nd stage, Mysore- 570023, Karnataka, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Conservative Dentistry & Endodontics, Luxmi Bai Institute of Dental Sciences & Hospital, Sirhind Road, Patiala 147003, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakashree","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Oral Medicine and Radiology; Maharishi Markandeshwar College of Dental Sciences and Research, Mullana, Ambala, 133207, Haryana, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyatam Maruti","family":"Karade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of conservative dentistry and endodontics, Bharati Vidyapeeth, (Deemed To Be University) Dental College and Hospital, Sangli 416 416, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:28:52Z","timestamp":1768361332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300214807.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300214807","relation":{},"ISSN":["0973-8894"],"issn-type":[{"value":"0973-8894","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}