{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T22:54:15Z","timestamp":1768863255640,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:p>Cytokines, such as TNF-\u03b1, IL-1, IL-6, and IL-17, are implicated in disease progression, their exact contribution and potential as biomarkers for diagnosis and treatment monitoring in RA patients require further exploration. Therefore, it is of interest to investigate the expression of inflammatory cytokines (TNF-\u03b1, IL-1, IL-6, and IL-17) in patients with rheumatoid arthritis (RA). Cytokine levels were measured in both blood and synovial fluid, revealing significant elevation in RA patients compared to healthy controls. A strong correlation between cytokine levels and disease activity was observed, emphasising their role in disease progression. Data show that cytokines could serve as biomarkers for RA diagnosis and for monitoring treatment. Further research is needed to explore targeted therapies based on cytokine profiles. This research advances knowledge by identifying inflammatory cytokines as key biomarkers for disease activity in rheumatoid arthritis.<\/jats:p>","DOI":"10.6026\/973206300215020","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:15:56Z","timestamp":1768817756000},"page":"5020-5024","source":"Crossref","is-referenced-by-count":0,"title":["Expression analysis of inflammatory cytokines in patients with rheumatoid arthritis"],"prefix":"10.6026","volume":"21","author":[{"name":"Department of Pathology, American University of Barbados, Wildey, Barbados (Caricom)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvester Noeldoss","family":"Lazarus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsh","family":"V. Salankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pharmacology, N.K.P. Salve Institute of Medical Sciences & Research Centre and Lata Mangeshkar Hospital, Nagpur, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medicine and Surgery, Amrita School of Medicine, Faridabad, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrit","family":"Podder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parth","family":"Jani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, Government Medical College, Bhavnagar, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Sonone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Biochemistry, SMBT IMSRC, Nashik, Maharashtra, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2025,12,15]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:16:01Z","timestamp":1768817761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/021\/973206300215020.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,15]]},"published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300215020","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}