{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:13:17Z","timestamp":1770333197740,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:p>The need to better understand the role of tumor necrosis factor-alpha (TNF-\u03b1) in Alzheimer's disease (AD) and its relationship with brain atrophy and cognitive decline is highly relevant. Therefore, it is of interest to investigate the role of tumor necrosis factor-alpha (TNF-\u03b1) in Alzheimer's disease (AD) by analyzing its relationship with brain atrophy and cognitive decline in 80 AD patients. Our results show a significant correlation between increased CSF TNF-\u03b1 levels and hippocampal atrophy. Additionally, TNF-\u03b1 level were associated with other clinical variables, emphasizing its role in neuroinflammation. Thus, TNF-\u03b1 as a potential biomarker for Alzheimer's disease progression. Further research is needed to assess its therapeutic potential. The advancement to knowledge in this study is the identification of a significant correlation between elevated TNF-\u03b1 levels and hippocampal atrophy in Alzheimer\u2019s disease, supporting TNF-\u03b1 as a potential biomarker for disease progression.<\/jats:p>","DOI":"10.6026\/973206300220047","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:44:33Z","timestamp":1770288273000},"page":"47-50","source":"Crossref","is-referenced-by-count":0,"title":["Exploring molecular pathways in Alzheimer's disease neurodegeneration using biomarkers"],"prefix":"10.6026","volume":"22","author":[{"name":"Department of Neurosurgery, R. G. Kar Medical College, Kolkata, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankan","family":"Mondal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology, AIIMS Gorakhpur, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Medicine and Surgery, Amrita School of Medicine, Faridabad, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrit","family":"Podder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology,  KMC Medical College & Hospital, Maharajganj, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parth","family":"Jani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of General Medicine, Government Medical College, Bhavnagar, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,1,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:44:34Z","timestamp":1770288274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300220047.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,31]]},"published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300220047","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}