{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:45:07Z","timestamp":1770338707375,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:p>Liver stiffness measurement (LSM) using transient elastography (TE) poorly predicts hepatocellular carcinoma risk in cirrhotic patients, despite its established role in fibrosis assessment. This case-control study compared 30 hepatocellular carcinoma (HCC) patients with cirrhosis to 30 cirrhosis-only patients using FibroScan\u00ae TE for LSM. HCC patients were older, mostly male, with Hepatitis C virus (HCV) as the primary cirrhosis cause, followed by alcohol; median LSM was higher in HCC (58.0 kPa) versus non-HCC (24.5 kPa). Stratum-specific likelihood ratios rose with LSM and multivariate analysis confirmed age, HCV, alcohol and LSM as independent HCC predictors; LSM \u226539.45 kPa showed 83% sensitivity and 80% specificity for HCC detection in cirrhosis. Elevated LSM strongly associates with HCC risk, supporting TE as a non-invasive tool, especially with HCV\/alcohol factors.<\/jats:p>","DOI":"10.6026\/973206300220169","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:11:53Z","timestamp":1770293513000},"page":"169-174","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between liver stiffness measurement and hepatocellular carcinoma risk: A case control study"],"prefix":"10.6026","volume":"22","author":[{"name":"Consultant, Vardhman Mahavir Hospital, Patiala, Punjab, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Garg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otolaryngology, Dayanand Medical College and hospital, Ludhiana, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staphy","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pulmonary Medicine, Government Medical College, Patiala, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Gastroenterology, Dayanand Medical college and Hospital Ludhiana, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Consultant, Fortis Hospital, Ludhiana, Punjab, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,1,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:11:57Z","timestamp":1770293517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300220169.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,31]]},"published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300220169","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}