{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:57:35Z","timestamp":1788188255760,"version":"build-2803163510"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:p>Oral squamous cell carcinoma (OSCC) outcomes require molecular markers beyond histological grading for reliable prognostication. Therefore, it is of interest to assess p53, Ki-67 and EGFR expression via immunohistochemistry in 96 confirmed OSCC cases, correlating with grade, lymph node metastasis and stage. All markers showed significantly elevated expression with advancing tumor grade (p53 in 78.1%, Ki-67 &gt;50% in poorly differentiated tumors, EGFR in 71.9% of cases). Combined positivity offered superior correlation with lymph node metastasis (p&lt;0.001) and advanced clinical stage versus individual markers. Integrated p53\/Ki-67\/EGFR assessment advances OSCC prognostication, warranting routine pathological use for enhanced clinical decision-making.<\/jats:p>","DOI":"10.6026\/973206300220470","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:28:36Z","timestamp":1770622116000},"page":"470-476","source":"Crossref","is-referenced-by-count":2,"title":["Comparative study of histological tumor markers (p53, Ki-67, EGFR) in grading and prognostication of oral squamous cell carcinoma"],"prefix":"10.6026","volume":"22","author":[{"name":"Department of Oral And Maxillofacial Pathology, S.B. Patil Institute For Dental Sciences And Research, Bidar, Karnataka, India","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Nazneen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Prosthodontics, Medical officer (Dental), District Hospital, Jabalpur, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushree","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral Pathology and Microbiology, Bhabha College of Dental Sciences, Bhopal, Madhya Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Rajashekhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Surgical Gastroenterology, King George medical university, Lucknow, Uttar Pradesh, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakshayani Vijay","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral Pathology and Microbiology, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarang","family":"K Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral & Maxillofacial Pathology, K. M. Shah dental college and hospital, Sumandeep Vidyapeeth deemed to be University, Vadodara, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2026,1,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:28:38Z","timestamp":1770622118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300220470.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,31]]},"published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300220470","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}