{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:55:46Z","timestamp":1783140946139,"version":"3.54.6"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:p>Oral Submucous Fibrosis (OSF) is a chronic, progressive, potentially malignant disorder associated with areca-nut exposure, characterized by persistent inflammation, extracellular matrix accumulation, and fibrotic restriction of oral function. This review highlights how fibrosis-driven vascular compromise and sustained hypoxia generate a tumor-promoting microenvironment that underlies malignant transformation. Dysregulated fibroblast activation, abnormal matrix remodeling, impaired angiogenesis, and chronic inflammatory signaling collectively promote stromal stiffness, oxidative stress, epithelial instability, and EMT-like changes. These interconnected angio-fibrotic and hypoxic mechanisms facilitate progression from fibrosis to epithelial dysplasia and ultimately oral squamous cell carcinoma. Understanding this pathogenic network provides a framework for early risk stratification and supports development of targeted anti-fibrotic and anti-angiogenic therapeutic strategies in OSF.<\/jats:p>","DOI":"10.6026\/973206300220610","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:37:02Z","timestamp":1772545022000},"page":"610-614","source":"Crossref","is-referenced-by-count":1,"title":["A review on angio-fibrotic pathways driving cancer potential in oral submucous fibrosis"],"prefix":"10.6026","volume":"22","author":[{"given":"Sneha Masne","family":"Deshpande","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Belapur, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Genesis Institute of Dental Sciences and Research, Firozpur, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Rebello","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology & Oral Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Gholap","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics & Crown and Bridge, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Belapur, Navi Mumbai, Maharashtra, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupa Roshan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Kharghar, Navi Mumbai 400089, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Shrikant Deshpande","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering, Sidus Buildcon India Private Limited, Navi Mumbai, Maharashtra, India; *Corresponding author"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2026,2,28]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:37:03Z","timestamp":1772545023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300220610.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,28]]},"published-print":{"date-parts":[[2026,2,28]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300220610","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}