{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:12:58Z","timestamp":1772554378844,"version":"3.50.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:p>Systemic Lupus Erythematosus (SLE) silently affects cardiac function, requiring early myocardial dysfunction detection to prevent morbidity. This hospital-based cross-sectional study assessed 49 SLE patients (2019 ACR\/EULAR criteria) via clinical exam, Electrocardiogram (ECG) and echocardiography including speckle-tracking Global Longitudinal Strain (GLS). Evaluated parameters included Left Ventricular Ejection Fraction (LVEF), diastolic function, valvular lesions, pericardial effusion, pulmonary pressures and GLS (values &lt; -16% indicating subclinical systolic dysfunction). Abnormal GLS occurred in 55.1%, with 28.5% showing preserved LVEF but impaired GLS, alongside systolic dysfunction (63.2%) and diastolic dysfunction (14.2%). GLS advances SLE cardiac screening by detecting subclinical LV impairment before LVEF decline, enabling timely intervention in preserved ejection fraction patients<\/jats:p>","DOI":"10.6026\/973206300220646","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:37:02Z","timestamp":1772545022000},"page":"646-650","source":"Crossref","is-referenced-by-count":0,"title":["Global longitudinal strain for early detection of subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus at a tertiary care centre: A hospital-based study"],"prefix":"10.6026","volume":"22","author":[{"given":"Krati","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Medicine, GMCH Nagpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Khandait","sequence":"additional","affiliation":[{"name":"Department of Medicine, GMCH Nagpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustubh","family":"Telang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, SSH Nagpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Sarwale","sequence":"additional","affiliation":[{"name":"Department of Cardiology, SSH Nagpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saransh","family":"Barai","sequence":"additional","affiliation":[{"name":"Department of Medicine, GMCH Nagpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,2,28]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:37:04Z","timestamp":1772545024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300220646.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,28]]},"published-print":{"date-parts":[[2026,2,28]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300220646","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}