{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T08:02:32Z","timestamp":1774080152017,"version":"3.50.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:p>An acquired pigmenting disorder, vitiligo, occurs worldwide with a prevalence of 0.5-2% and in India with 0.25%-4%. Stress-related pathways are involved may contribute to autoimmune melanocyte loss and HSP-70 (a stress-response molecular chaperone with immune-modulatory effects) may be a key link between stress and disease activity. In this case\u2013control study, 40 vitiligo patients and 40 age and sex-matched controls underwent skin biopsies (lesional and non-lesional skin in patients; normal skin in controls) and HSP-70 mRNA expression was quantified using real-time PCR; patients were also grouped as highly active, moderately active or inactive based on clinical activity. Lesional vitiligo skin showed significantly higher HSP-70 expression than non-lesional skin and control skin (both P &lt; 0.001), with higher mean levels in active compared with inactive vitiligo, while no association was found with age, sex or disease duration-supporting a role of HSP-70\u2013related stress mechanisms in vitiligo pathogenesis and activity.<\/jats:p>","DOI":"10.6026\/973206300221285","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:34:02Z","timestamp":1774074842000},"page":"1285-1288","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of disease activity in vitiligo patients and its relation with HSP70 expression"],"prefix":"10.6026","volume":"22","author":[{"given":"Anup Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shyam Shah Medical College and associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devesh","family":"Saraswat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shyam Shah Medical College and associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneel Singh","family":"Sengar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shyam Shah Medical College and associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayushi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shyam Shah Medical College and associated Hospitals, Rewa, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Multi-Disciplinary Research Unit, Shyam Shah Medical College Rewa, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,2,28]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:34:03Z","timestamp":1774074843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300221285.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,28]]},"published-print":{"date-parts":[[2026,2,28]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300221285","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}