{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:20:36Z","timestamp":1775316036662,"version":"3.50.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:p>Clear aligners are increasingly being used for complex malocclusions; however, adequate outcome data comparing them with fixed appliances in high-difficulty cases is still limited. Therefore, it is of interest to compare occlusal outcomes, efficiency and patient-reported experience between clear aligners and fixed appliances in complex orthodontic cases. Using a prospective comparative design, complex cases were randomly assigned to treatment with clear aligner therapy or conventional fixed appliances and assessed by Peer Assessment Rating (PAR) score change, length of treatment time needed, burden of appointments required, refinements\/finishes and OHIP-14. Both modalities produced clinically significant occlusal correction; however, fixed appliances showed increased efficiency in extraction heavy biomechanics while aligners showed increased initial patient-reported comfort and oral health related quality of life. Aligners may be useful in complex cases when biomechanics has been well-staged and compliance is high and yet fixed appliances might still be beneficial in providing efficiency benefits in hard-to-root control and extraction space closure.<\/jats:p>","DOI":"10.6026\/973206300221429","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:31:48Z","timestamp":1775313108000},"page":"1429-1432","source":"Crossref","is-referenced-by-count":0,"title":["Management of complex orthodontic cases using aligners: A comparative study"],"prefix":"10.6026","volume":"22","author":[{"given":"Mohammed Ali Hamid","family":"Syed","sequence":"first","affiliation":[{"name":"Department Orthodontics and Dentofacial Orthopedics, Al harkan Medical Center, Unaizah, Al Qassim, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaitanya","family":"Chappidi","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Metro Health Family Dentistry, Cleveland, Ohio, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan","family":"Mubashir","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopaedics, Al Jouf Specialised Dental Center, Ministry of Health, Sakaka, Al Jouf Province, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Nalanda Medical College Hospital, Agamkuan, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LahariPriya","family":"Singareddy","sequence":"additional","affiliation":[{"name":"Department of Public Health, St. Francis College, New York, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Dental Research Cell, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune 411018, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heena Dixit","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of blood cell, Consultant, Blood Cell, Commissionerate of Health and Family Welfare, Government of Telangana, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,3,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:31:48Z","timestamp":1775313108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300221429.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,31]]},"published-print":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300221429","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}