{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:12:17Z","timestamp":1778137937824,"version":"3.51.4"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Current periodontal therapies fail to predictably restore the complete architecture of alveolar bone, periodontal ligament and cementum lost due to periodontal disease. Stem cell\u2013based scaffolds have emerged as a biological strategy to enhance coordinated periodontal regeneration through combined cellular and biomaterial approaches. Therefore, it is of interest to evaluate preclinical and clinical evidence on dental pulp stem cell and adipose-derived stem cell\u2013based scaffolds in periodontal regeneration. Animal studies consistently demonstrate enhanced new bone formation, cementum-like tissue deposition, organized periodontal ligament\u2013like fibers and improved vascularization compared to scaffold-only controls. Thus, we report reductions in probing depth, gains in clinical attachment and favorable safety profiles, although standardized protocols and long-term data remain limited.<\/jats:p>","DOI":"10.6026\/973206300222015","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:34:02Z","timestamp":1778135642000},"page":"2015-2019","source":"Crossref","is-referenced-by-count":0,"title":["Stem cell-based scaffolds using dental pulp and adipose-derived stem cells in periodontal regeneration: Evidence from preclinical or clinical studies"],"prefix":"10.6026","volume":"22","author":[{"given":"Manimekalai","family":"Muthusamy","sequence":"first","affiliation":[{"name":"Department of Periodontics, Chettinad Institute of Higher Education and Research, Rajiv Gandhi Salai, Kelambakkam, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena","family":"George","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sree Mookambika Institute of Dental Sciences, Padanilam, Kulasekharam 629161, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Cholanagar, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siladitya","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Dentistry, JIMSH, K. P. Mondal Road, Buita, Budge Budge, Kolkata- 700137, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suma","family":"Janya","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, RUAS (Ramaiah university of applied sciences), Msrit Edu campus New BEL Road, Bengaluru \u2013 560064, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu Devanahalli","family":"Rajanna","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dayanada Sagar College of Dental Sciences, Kumaraswamy Layout, Bengaluru, Karnataka 560111, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,4,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:34:12Z","timestamp":1778135652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300222015.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,30]]},"published-print":{"date-parts":[[2026,4,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300222015","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}