{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:15:11Z","timestamp":1778163311757,"version":"3.51.4"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Adipogenesis involves adipocyte differentiation and synthesis and storage of fats. PPAR-\u03b4 is the master regulator of adipogenesis and regulates genes for adipocyte differentiation, lipogenesis, adipocyte survival and adipokine secretion. Central carbon metabolism (CCM) comprises of three key pathways glycolysis, tricarboxylic acid (TCA) cycle and pentose phosphate pathway (PPP). CCM utilizes carbon sources to provide energy and building blocks for lipogenesis. Several targets of transcription factor PPAR-\u03b4 have been identified in CCM pathways. However, the exact mechanism of PPAR-\u03b4 modulation in adipogenesis via CCM remains elusive. Therefore, it is of interest to evaluate the effects of PPAR-\u03b4 on CCM in differentiated human SGBS adipocytes by real time-qPCR and metabolomics using its agonist 15d-PGJ2 and antagonist GW9662. Surprisingly, our results suggest that PPAR-\u03b4 rather than PPAR-\u03b4 is likely to be the key modulator of CCM in differentiated adipocytes at least under current experimental conditions with both 15d PGJ2 and GW9662 being PPAR-\u03b4 agonists, although PPAR-\u03b4 plays a crucial role in adipogenesis and lipogenesis. This data provides insight to manage obesity and diabetes using PPAR-\u03b4 agonists. Further studies are warranted to explore the regulation of CCM by PPARs in adipocytes.<\/jats:p>","DOI":"10.6026\/973206300222419","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:50:27Z","timestamp":1778161827000},"page":"2419-2429","source":"Crossref","is-referenced-by-count":0,"title":["PPAR-\u03b4 is a potential modulator of central carbon metabolism in human adipocytes"],"prefix":"10.6026","volume":"22","author":[{"given":"Leilei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Nutrition Sciences, Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, Ulm University Medical Center Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Nutrition Sciences, Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena Kishor","family":"Sakharkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Nutrition Sciences, Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2026,4]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:50:28Z","timestamp":1778161828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300222419.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]},"published-print":{"date-parts":[[2026,4,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300222419","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}