{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:59:26Z","timestamp":1780750766621,"version":"3.54.1"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:p>Sertraline, a selective serotonin reuptake inhibitor (SSRI), is widely used for treating depression and anxiety disorders, including during pregnancy, yet its potential effects on fetal development remain a concern. Oxidative stress is considered a possible mechanism for drug-induced developmental toxicity, suggesting antioxidant supplementation may mitigate such effects. Therefore, it is of interest to assess the fetotoxic potential of sertraline and the protective role of Vitamin E in eighteen pregnant Swiss albino mice divided into control, sertraline-treated (60 mg\/kg\/day) and sertraline + Vitamin E (100 mg\/kg\/day) groups. Treatments were given orally from gestational day 6\u201315, followed by evaluation of fetal growth and organ histopathology on day 19. Sertraline exposure significantly reduced fetal number, weight, crown\u2013rump length and placental metrics, with marked cardiac, hepatic and renal alterations, while Vitamin E co-administration partly ameliorated these effects. Thus, we show oxidative stress in sertraline-induced fetal toxicity and demonstrating the partial protective potential of Vitamin E supplementation.<\/jats:p>","DOI":"10.6026\/973206300223060","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:13:17Z","timestamp":1780747997000},"page":"3060-3066","source":"Crossref","is-referenced-by-count":0,"title":["Sertraline-induced fetotoxicity in mice: Protective effects of vitamin E on foetal growth and organ histology"],"prefix":"10.6026","volume":"22","author":[{"given":"Amit Kumar","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Devadas","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Jawed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2026,5,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:13:19Z","timestamp":1780747999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300223060.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,31]]},"published-print":{"date-parts":[[2026,5,31]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300223060","relation":{},"ISSN":["0973-8894"],"issn-type":[{"value":"0973-8894","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,31]]}}}