{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:45:27Z","timestamp":1782650727629,"version":"3.54.5"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Oral squamous cell carcinoma (OSCC) is the predominant form of oral malignancy, with late-stage diagnosis contributing to poor prognosis. Oral potentially malignant disorders (OPMDs) often precede OSCC, underscoring the need for early diagnostic biomarkers. Hence, salivary cathelicidin LL-37 levels were quantified using ELISA in 80 participants.  Participants were divided into four groups: OSCC, tobacco-associated OPMDs, non-tobacco-associated OPMDs, and healthy controls. Salivary cathelicidin LL-37 levels increased progressively from healthy controls to OSCC cases (p &lt; 0.001) with 100% sensitivity and 90% specificity. Thus, we show that salivary LL-37 is a reliable, non-invasive biomarker for early detection and monitoring of oral carcinogenesis.<\/jats:p>","DOI":"10.6026\/973206300223421","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:25:16Z","timestamp":1782649516000},"page":"3421-3424","source":"Crossref","is-referenced-by-count":0,"title":["Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection"],"prefix":"10.6026","volume":"22","author":[{"given":"Thaneja","family":"Ravichandran","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Meenakshi Ammal Dental College, Meenakshi academy of higher education and research, MAHER University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:25:19Z","timestamp":1782649519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300223421.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2026,6,30]]},"published-print":{"date-parts":[[2026,6,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300223421","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}