{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:45:29Z","timestamp":1782650729278,"version":"3.54.5"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Reconstruction of oral soft-tissue defects remains limited by donor-site morbidity and inconsistent healing with currently available grafts. In this prospective interventional study, we assessed human amniotic membrane (HAM) as a biologically active scaffold in 15 patients (6 cleft alveolus, 2 oral submucous fibrosis, 7 vestibuloplasty; ages 8\u201365 years). HAM integrated without complications in all cases, with no necrosis, infection, or immunologic rejection; median pain (VAS) fell from 2 on day 1 to 0 by day 7 (p &lt; 0.00001) and swelling resolved by day 7 (p &lt; 0.00001). Epithelialization reached \"good\" by 1 month (p &lt; 0.00001); mucosal suppleness remained preserved through 6 months and in OSMF cases interincisal opening improved to 35\u201350 mm. Thus, data shows the HAM as a safe, donor-site\u2013sparing, clinically translatable biomaterial that accelerates healing and improves function in oral soft-tissue reconstruction.<\/jats:p>","DOI":"10.6026\/973206300223527","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:25:16Z","timestamp":1782649516000},"page":"3527-3533","source":"Crossref","is-referenced-by-count":0,"title":["Amniotic membrane for oral surgical defect coverage: A clinical study"],"prefix":"10.6026","volume":"22","author":[{"given":"Meenakshi","family":"Kothari","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, H.K.E\u2019s S. Nijalingappa Institute of Dental Sciences and Research Centre, Kalaburagi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:25:25Z","timestamp":1782649525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/022\/973206300223527.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2026,6,30]]},"published-print":{"date-parts":[[2026,6,30]]}},"URL":"https:\/\/doi.org\/10.6026\/973206300223527","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}