{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:19:16Z","timestamp":1789604356622,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.6061\/clinics\/2012(03)06","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T08:15:17Z","timestamp":1331280917000},"page":"237-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Isolated limb perfusion with hyperthermia and chemotherapy: predictive factors for regional toxicity"],"prefix":"10.1016","volume":"67","author":[{"given":"Jo\u00e3o Pedreira Duprat","family":"Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bertolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Sapata","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nishinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Facure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Humberto","family":"Fregnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.6061\/clinics\/2012(03)06_bib1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/bjs.1800831004","article-title":"Thirty-five years of isolated limb perfusion for melanoma: indications and results","volume":"83","author":"Vrouenraets","year":"1996","journal-title":"Br J Surg"},{"issue":"4","key":"10.6061\/clinics\/2012(03)06_bib2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00000658-195010000-00018","article-title":"Fractionated intra-arterial cancer; chemotherapy with methyl bis amine hydrochloride; a preliminary report","volume":"132","author":"Klopp","year":"1950","journal-title":"Ann Surg"},{"issue":"3205","key":"10.6061\/clinics\/2012(03)06_bib3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.123.3205.984","article-title":"Action of p-[di(2-chloroethyl)]-amino-l-phenylalanine on Harding-Passey mouse melanoma","volume":"123","author":"Luck","year":"1956","journal-title":"Science"},{"issue":"4","key":"10.6061\/clinics\/2012(03)06_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/jama.1959.03000210033008","article-title":"Treatment of melanoma by isolation-perfusion technique","volume":"169","author":"Creech","year":"1959","journal-title":"J Am Med Assoc"},{"issue":"9","key":"10.6061\/clinics\/2012(03)06_bib5","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/1097-0142(196709)20:9<1351::AID-CNCR2820200902>3.0.CO;2-#","article-title":"Selective heat sensitivity of cancer cells. Biochemical and clinical studies","volume":"20","author":"Cavaliere","year":"1967","journal-title":"Cancer"},{"issue":"5","key":"10.6061\/clinics\/2012(03)06_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0748-7983(96)93085-1","article-title":"Systemic toxicity after isolated limb perfusion with melphalan for melanoma","volume":"22","author":"Sonneveld","year":"1996","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"10.6061\/clinics\/2012(03)06_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10434-999-0405-9","article-title":"Absence of severe systemic toxicity after leakage-controlled isolated limb perfusion with tumor necrosis factor-alpha and melphalan","volume":"6","author":"Vrouenraets","year":"1999","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.6061\/clinics\/2012(03)06_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00008390-199512000-00006","article-title":"Severe acute regional toxicity after normothermic or \u2018mild\u2019 hyperthermic isolated limb perfusion with melphalan for melanoma","volume":"5","author":"Vrouenraets","year":"1995","journal-title":"Melanoma Res"},{"issue":"6","key":"10.6061\/clinics\/2012(03)06_bib9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/0002-9610(94)90111-2","article-title":"Patient- and treatment-related factors associated with acute regional toxicity after isolated perfusion for melanoma of the extremities","volume":"167","author":"Klaase","year":"1994","journal-title":"Am J Surg"},{"issue":"2","key":"10.6061\/clinics\/2012(03)06_bib10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jamcollsurg.2011.03.013","article-title":"Current Trends in Regional Therapy for Melanoma: Lessons Learned from 225 Regional Chemotherapy Treatments between 1995 and 2010 at a Single Institution","volume":"213","author":"Raymond","year":"2011","journal-title":"J Am Coll Surg"},{"issue":"5","key":"10.6061\/clinics\/2012(03)06_bib11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S1072-7515(99)00018-6","article-title":"Relation between limb toxicity and treatment outcomes after isolated limb perfusion for recurrent melanoma","volume":"188","author":"Vrouenraets","year":"1999","journal-title":"J Am Coll Surg"},{"issue":"3","key":"10.6061\/clinics\/2012(03)06_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00008390-199606000-00010","article-title":"Determinants of acute regional toxicity following isolated limb perfusion for melanoma","volume":"6","author":"Thompson","year":"1996","journal-title":"Melanoma Res"},{"key":"10.6061\/clinics\/2012(03)06_bib13","first-page":"4","article-title":"Relation between calculated melphalan peak concentrations and toxicity in regional isolated perfusion for melanoma","volume":"4","author":"Klaase","year":"1992","journal-title":"Reg Cancer Treat"},{"issue":"4","key":"10.6061\/clinics\/2012(03)06_bib14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1634\/theoncologist.2009-0325","article-title":"Isolated limb perfusion for malignant melanoma: systematic review on effectiveness and safety","volume":"15","author":"Moreno-Ramirez","year":"2010","journal-title":"Oncologist"},{"issue":"5","key":"10.6061\/clinics\/2012(03)06_bib15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1053\/ejso.1999.0686","article-title":"Long-term functional morbidity after mild hyperthermic isolated limb perfusion with melphalan","volume":"25","author":"Vrouenraets","year":"1999","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"10.6061\/clinics\/2012(03)06_bib16","article-title":"Perfus\u00e3o isolada de membro com hipertermia na tratamento das met\u00e1stases em tr\u00e2nsito do melanoma cut\u00e2neo","volume":"35","author":"pasin","year":"2008","journal-title":"Revista Col\u00e9gio Brasileiro de Cirurgi\u00f5es"},{"issue":"6","key":"10.6061\/clinics\/2012(03)06_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ejso.2008.10.002","article-title":"Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinoma","volume":"35","author":"Duprat","year":"2009","journal-title":"Eur J Surg Oncol"},{"issue":"10","key":"10.6061\/clinics\/2012(03)06_bib18","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0277-5379(82)90235-8","article-title":"Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions","volume":"18","author":"Wieberdink","year":"1982","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.6061\/clinics\/2012(03)06_bib19","first-page":"46","article-title":"Handbook for Reporting Results of Cancer Treatment","author":"Organization WH","year":"1979","journal-title":"Who Offset Publication No 48"},{"issue":"17","key":"10.6061\/clinics\/2012(03)06_bib20","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1097\/00002030-200012010-00027","article-title":"Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis","volume":"14","author":"Brinkman","year":"2000","journal-title":"AIDS"},{"issue":"1","key":"10.6061\/clinics\/2012(03)06_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/02656730903236086","article-title":"Long-term outcome of hyperthermic isolated limb perfusion (HILP) in the treatment of locoregionally metastasised malignant melanoma of the extremities","volume":"26","author":"Boesch","year":"2010","journal-title":"Int J Hyperthermia"},{"issue":"3","key":"10.6061\/clinics\/2012(03)06_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/08941939409018290","article-title":"Comparison between the use of whole blood versus a diluted perfusate in regional isolated perfusion by continuous monitoring of transcutaneous oxygen tension: a pilot study","volume":"7","author":"Klaase","year":"1994","journal-title":"J Invest Surg"},{"key":"10.6061\/clinics\/2012(03)06_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1756-9966-27-67","article-title":"Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: the experience of the Tuscan Reference Centre","volume":"27","author":"Pace","year":"2008","journal-title":"J Exp Clin Cancer Res"},{"issue":"Suppl 1","key":"10.6061\/clinics\/2012(03)06_bib24","first-page":"45","article-title":"Maximizing efficacy and minimizing toxicity in isolated limb perfusion for melanoma","volume":"4","author":"Thompson","year":"1994","journal-title":"Melanoma Res"},{"key":"10.6061\/clinics\/2012(03)06_bib25","first-page":"3","article-title":"The value of monitoring serum creatine phosphokinase following hyperthermic isolated limb perfusion for melanoma","volume":"1","author":"Lai","year":"1993","journal-title":"Reg Cancer Treat"},{"issue":"3","key":"10.6061\/clinics\/2012(03)06_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<224::AID-SSU6>3.0.CO;2-A","article-title":"Toxicity and morbidity of isolated limb perfusion","volume":"14","author":"Vrouenraets","year":"1998","journal-title":"Semin Surg Oncol"},{"issue":"1","key":"10.6061\/clinics\/2012(03)06_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF02316815","article-title":"Value of laboratory tests in monitoring acute regional toxicity after isolated limb perfusion","volume":"4","author":"Vrouenraets","year":"1997","journal-title":"Ann Surg Oncol"},{"key":"10.6061\/clinics\/2012(03)06_bib28","series-title":"Cutaneous melanoma: clinical management and treatment worldwide","first-page":"171","article-title":"Hypertermic regional perfusion of the limbs","author":"Krementz","year":"1985"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222018580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222018580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/clinics.org.br\/uploads\/artigos\/cln-67-03\/cln-67-03-237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:08:32Z","timestamp":1761721712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222018580"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_abstract&pid=S1807-59322012000300006&lng=en&nrm=iso","label":"SCIELO"},{"URL":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3297032\/?report=classic","label":"PMC"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1807593222018580"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2012(03)06","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolated limb perfusion with hyperthermia and chemotherapy: predictive factors for regional toxicity","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2012(03)06","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}