{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:53:45Z","timestamp":1771516425728,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"vor","delay-in-days":316,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2012]]},"DOI":"10.6061\/clinics\/2012(11)06","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T09:13:16Z","timestamp":1352279596000},"page":"1259-1263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pleural tuberculosis: is radiological evidence of pulmonary-associated disease related to the exacerbation of the inflammatory response?"],"prefix":"10.1016","volume":"67","author":[{"given":"Leila","family":"Antonangelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco S","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Puka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Seiscento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena M P","family":"Acencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisete R","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo M","family":"Terra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta K B","family":"Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1440-1843.2010.01723.x","article-title":"Update on tuberculous pleural effusion","volume":"15","author":"Light","year":"2010","journal-title":"Respirology"},{"issue":"5","key":"10.6061\/clinics\/2012(11)06_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00408-009-9165-3","article-title":"Tuberculous pleural effusion","volume":"187","author":"Porcel","year":"2009","journal-title":"Lung"},{"issue":"4","key":"10.6061\/clinics\/2012(11)06_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1378\/chest.06-2352","article-title":"Pleural tuberculosis in the United States: incidence and drug resistance","volume":"131","author":"Baumann","year":"2007","journal-title":"Chest"},{"issue":"2","key":"10.6061\/clinics\/2012(11)06_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0953-6205(03)00018-9","article-title":"Tuberculous pleural effusions","volume":"14","author":"Valdes","year":"2003","journal-title":"European journal of internal medicine"},{"key":"10.6061\/clinics\/2012(11)06_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-065X.2008.00702.x","article-title":"The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis","volume":"226","author":"Cooper","year":"2008","journal-title":"Immunol Rev"},{"issue":"2","key":"10.6061\/clinics\/2012(11)06_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000113629","article-title":"Pathophysiology of the pleura","volume":"75","author":"Jantz","year":"2008","journal-title":"Respiration"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1183\/09031936.03.00403902","article-title":"Immunological mechanisms in pleural disease","volume":"21","author":"Antony","year":"2003","journal-title":"Eur Respir J"},{"issue":"2","key":"10.6061\/clinics\/2012(11)06_bib8","first-page":"6","article-title":"Differential cytokine\/chemokines and KL-6 profiles in patients with different forms of tuberculosis","volume":"47","author":"Siawaya","year":"2009","journal-title":"Cytokine"},{"issue":"9","key":"10.6061\/clinics\/2012(11)06_bib9","first-page":"8","article-title":"Pleural fluid cytokines correlate with tissue inflammatory expression in tuberculosis","volume":"14","author":"Seiscento","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"issue":"1","key":"10.6061\/clinics\/2012(11)06_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/MI.2005.2","article-title":"The differential diagnostic values of cytokine levels in pleural effusions","volume":"2005","author":"Akarsu","year":"2005","journal-title":"Mediators Inflamm"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib11","first-page":"14","article-title":"Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions","author":"Pokkali","year":"2008","journal-title":"Cytokine"},{"issue":"6","key":"10.6061\/clinics\/2012(11)06_bib12","first-page":"6","article-title":"Differential cytokine levels and immunoreactivities against Mycobacterium tuberculosis antigens between tuberculous and malignant effusions","volume":"102","author":"Yang","year":"2008","journal-title":"Respir Med"},{"issue":"1","key":"10.6061\/clinics\/2012(11)06_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0954-6111(98)90025-7","article-title":"Compartmentalization of pro-inflammatory cytokines in tuberculous pleurisy","volume":"92","author":"Hoheisel","year":"1998","journal-title":"Respir Med"},{"issue":"2","key":"10.6061\/clinics\/2012(11)06_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.icb.7100027","article-title":"Life and death in the granuloma: immunopathology of tuberculosis","volume":"85","author":"Saunders","year":"2007","journal-title":"Immunology and cell biology"},{"issue":"5","key":"10.6061\/clinics\/2012(11)06_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-3083.2003.01201.x","article-title":"Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta","volume":"57","author":"Park","year":"2003","journal-title":"Scandinavian journal of immunology"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3346\/jkms.2000.15.3.279","article-title":"Vascular endothelial growth factor in malignant and tuberculous pleural effusions","volume":"15","author":"Lim","year":"2000","journal-title":"J Korean Med Sci"},{"issue":"10","key":"10.6061\/clinics\/2012(11)06_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/rmed.2002.1364","article-title":"Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions","volume":"96","author":"Momi","year":"2002","journal-title":"Respir Med"},{"issue":"1","key":"10.6061\/clinics\/2012(11)06_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1440-1843.2003.00529.x","article-title":"Vasoactive mediators (VEGF and TNF-\u03b1) in patients with malignant and tuberculous pleural effusions","volume":"9","author":"Hamed","year":"2004","journal-title":"Respirology"},{"issue":"5","key":"10.6061\/clinics\/2012(11)06_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1378\/chest.116.5.1292","article-title":"Proinflammatory cytokines and fibrinolytic enzymes in tuberculous and malignant pleural effusions","volume":"116","author":"Hua","year":"1999","journal-title":"Chest"},{"issue":"1","key":"10.6061\/clinics\/2012(11)06_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-3083.2001.00844.x","article-title":"Circulating TNF-\u03b1, TGF-\u03b2, and IL-10 in tuberculosis patients and healthy contacts","volume":"53","author":"Olobo","year":"2001","journal-title":"Scandinavian journal of immunology"},{"issue":"18","key":"10.6061\/clinics\/2012(11)06_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1001\/archinte.158.18.2017","article-title":"Tuberculous pleurisy: a study of 254 patients","volume":"158","author":"Vald\u00e9s","year":"1998","journal-title":"Arch Intern Med"},{"issue":"5","key":"10.6061\/clinics\/2012(11)06_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1378\/chest.129.5.1253","article-title":"The prevalence of pulmonary parenchymal tuberculosis in patients with tuberculous pleuritis","volume":"129","author":"Kim","year":"2006","journal-title":"Chest"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejrad.2008.12.009","article-title":"Utility of high-resolution computed tomography for predicting risk of sputum smear-negative pulmonary tuberculosis","volume":"73","author":"Nakanishi","year":"2010","journal-title":"Eur J Radiol"},{"issue":"7","key":"10.6061\/clinics\/2012(11)06_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.rmed.2011.02.014","article-title":"Pulmonary involvement in pleural tuberculosis: how often does it mean disease activity","volume":"105","author":"Seiscento","year":"2011","journal-title":"Respir Med"},{"issue":"4","key":"10.6061\/clinics\/2012(11)06_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1590\/S1807-59322011000400005","article-title":"Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis","volume":"66","author":"Chung","year":"2011","journal-title":"Clinics"},{"key":"10.6061\/clinics\/2012(11)06_bib26","series-title":"Methods of Enzymatic Analysis","first-page":"1092","article-title":"Adenosine deaminase","author":"Giusti","year":"1974"},{"key":"10.6061\/clinics\/2012(11)06_bib27","first-page":"A605","article-title":"Citokines in pleural effusions","volume":"168","author":"Marchi","year":"2002","journal-title":"Am J Respir and Critical Care Medicine"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00408-004-2533-0","article-title":"Angiogenic Factors and angiogenesis inhibitors in exudative pleural effusions","volume":"183","author":"Ruiz","year":"2005","journal-title":"Lung"},{"issue":"3","key":"10.6061\/clinics\/2012(11)06_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1440-1843.2003.00474.x","article-title":"Transforming growth factor beta-1 level in pleural effusion","volume":"8","author":"Ceyhan","year":"2003","journal-title":"Respirology"},{"issue":"4","key":"10.6061\/clinics\/2012(11)06_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jtbi.2010.05.012","article-title":"TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model","volume":"265","author":"Marino","year":"2010","journal-title":"J Theor Biol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222021937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222021937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/clinics.org.br\/uploads\/artigos\/cln-67-11\/cln-67-11-1259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:10:21Z","timestamp":1761721821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222021937"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_abstract&pid=S1807-59322012001100006&lng=en&nrm=iso","label":"SCIELO"},{"URL":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3488982\/?report=classic","label":"PMC"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1807593222021937"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2012(11)06","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pleural tuberculosis: is radiological evidence of pulmonary-associated disease related to the exacerbation of the inflammatory response?","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2012(11)06","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}