{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:49:28Z","timestamp":1787870968501,"version":"build-2784847793"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":364,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2018]]},"DOI":"10.6061\/clinics\/2018\/e310","type":"journal-article","created":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T13:10:36Z","timestamp":1525007436000},"page":"e310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis"],"prefix":"10.1016","volume":"73","author":[{"given":"Pedro","family":"Giavina-Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Karla","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo V.","family":"Aun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis A.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herberto J.","family":"Chong-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemeire N.","family":"Constantino-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima R.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana P.L.","family":"Ferriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfeu T.","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana F.B.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Komninakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana S.M.","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio A.","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B.","family":"Pesquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Portilho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson A.","family":"Ros\u00e1rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faradiba S.","family":"Serpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirceu","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Takejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange O.R.","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila L.","family":"Veronez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anete S.","family":"Grumach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.6061\/clinics\/2018\/e310_bib1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1590\/S1807-59322011000900021","article-title":"Brazilian guidelines for the diagnosis and treatment of hereditary angioedema","volume":"66","author":"Giavina-Bianchi","year":"2011","journal-title":"Clinics"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00005792-199207000-00003","article-title":"Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients","volume":"71","author":"Agostoni","year":"1992","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00000441-198207000-00001","article-title":"Hereditary angioedema: an appraisal of 104 cases","volume":"284","author":"Cicardi","year":"1982","journal-title":"Am J Med Sci"},{"issue":"5","key":"10.6061\/clinics\/2018\/e310_bib4","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/all.12380","article-title":"Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group","volume":"69","author":"Cicardi","year":"2014","journal-title":"Allergy"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2005.09.064","article-title":"Hereditary angioedema: new findings concerning symptoms, affected organs, and course","volume":"119","author":"Bork","year":"2006","journal-title":"Am J Med"},{"issue":"12","key":"10.6061\/clinics\/2018\/e310_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/WOX.0b013e318279affa","article-title":"WAO Guideline for the management of hereditary angioedema","volume":"5","author":"Craig","year":"2012","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.6061\/clinics\/2013(01)OA13","article-title":"Hereditary angioedema: quality of life in Brazilian patients","volume":"68","author":"Gomide","year":"2013","journal-title":"Clinics"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jaip.2015.12.010","article-title":"Psychometric field study of hereditary angioedema Quality of Life Questionnaire for adults: HAE-QoL","volume":"4","author":"Prior","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"10.6061\/clinics\/2018\/e310_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2500\/aap.2010.31.3394","article-title":"The humanistic burden of hereditary angioedema: impact on health-related quality of life, productivity, and depression","volume":"31","author":"Lumry","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib10","doi-asserted-by":"crossref","first-page":"e713","DOI":"10.1542\/peds.2006-3303","article-title":"Management of hereditary angioedema in pediatric patients","volume":"120","author":"Farkas","year":"2007","journal-title":"Pediatrics"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.anai.2009.12.004","article-title":"Is there a need for clinical guidelines in the United States for the diagnosis of hereditary angioedema and the screening of family members of affected patients","volume":"104","author":"Lunn","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3 Suppl","key":"10.6061\/clinics\/2018\/e310_bib12","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.jaci.2004.06.047","article-title":"Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond","volume":"114","author":"Agostoni","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1710-1492-6-22","article-title":"HAE international home therapy consensus document","volume":"6","author":"Longhurst","year":"2010","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1710-1492-6-24","article-title":"International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema","volume":"6","author":"Bowen","year":"2010","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"9225","key":"10.6061\/clinics\/2018\/e310_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(00)02483-1","article-title":"Hereditary angioedema with normal C1-inhibitor activity in women","volume":"356","author":"Bork","year":"2000","journal-title":"Lancet"},{"issue":"10","key":"10.6061\/clinics\/2018\/e310_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archinte.163.10.1229","article-title":"Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency","volume":"163","author":"Bork","year":"2003","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1710-1492-6-15","article-title":"Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor","volume":"6","author":"Bork","year":"2010","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"10","key":"10.6061\/clinics\/2018\/e310_bib18","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0196-0644(88)80450-5","article-title":"Hereditary angioedema","volume":"17","author":"Moore","year":"1988","journal-title":"Ann Emerg Med"},{"issue":"10","key":"10.6061\/clinics\/2018\/e310_bib19","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1097\/00042737-200110000-00016","article-title":"Ultrasonography in the diagnosis and monitoring of ascites in acute abdominal attacks of hereditary angioneurotic oedema","volume":"13","author":"Farkas","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1572-0241.2006.00492.x","article-title":"Symptoms, course, and complications of abdominal attacks in hereditary angioedema due to C1 inhibitor deficiency","volume":"101","author":"Bork","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1067\/mai.2000.104780","article-title":"Detection of C1 inhibitor mutations in patients with hereditary angioedema","volume":"105","author":"Zuraw","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/clim.2000.4947","article-title":"A review of the reported defects in the human C1 esterase inhibitor gene producing hereditary angioedema including four new mutations","volume":"98","author":"Bowen","year":"2001","journal-title":"Clin Immunol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.iac.2013.07.002","article-title":"Hereditary angioedema with normal C1 inhibitor","volume":"33","author":"Bork","year":"2013","journal-title":"Immunol Allergy Clin North Am"},{"issue":"8","key":"10.6061\/clinics\/2018\/e310_bib24","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/all.12648","article-title":"Hereditary angioedema with normal C1-INH with versus without specific F12 gene mutations","volume":"70","author":"Bork","year":"2015","journal-title":"Allergy"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib25","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/cea.12551","article-title":"Classification of angioedema by endotypes","volume":"45","author":"Giavina-Bianchi","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.6061\/clinics\/2018\/e310_bib26","first-page":"3","article-title":"\u00dcber akutes umschriebenes Haut\u00f6dem","volume":"1","author":"Quincke","year":"1982","journal-title":"Monatsh Prakt Dermatol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/ACI.0000000000000292","article-title":"Angioedema associated with nonsteroidal anti-inflammatory drugs","volume":"16","author":"Giavina-Bianchi","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaip.2014.03.014","article-title":"Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis","volume":"2","author":"Aun","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.6061\/clinics\/2018\/e310_bib29","first-page":"6","article-title":"Hereditary angioneurotic edema","volume":"95","author":"Osler","year":"1888","journal-title":"Am J Med Sci"},{"issue":"10","key":"10.6061\/clinics\/2018\/e310_bib30","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/j.1365-2222.2004.02070.x","article-title":"Self-reported drug allergy in a general adult Portuguese population","volume":"34","author":"Gomes","year":"2004","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1081-1206(10)62221-1","article-title":"Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes","volume":"87","author":"Stevenson","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"10","key":"10.6061\/clinics\/2018\/e310_bib32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski","year":"2013","journal-title":"Allergy"},{"key":"10.6061\/clinics\/2018\/e310_bib33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0021-8707(62)90032-1","article-title":"Hereditary angioneurotic edema. II. Deficiency of inhibitor for serum globulin permeability factor and\/or plasma kallikrein","volume":"33","author":"Landerman","year":"1962","journal-title":"J Allergy"},{"key":"10.6061\/clinics\/2018\/e310_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A biochemical abnormality in herediatry angioneurotic edema: absence of serum inhibitor of C'1-esterase","volume":"35","author":"Donaldson","year":"1963","journal-title":"Am J Med"},{"issue":"3672","key":"10.6061\/clinics\/2018\/e310_bib35","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.148.3672.957","article-title":"Hereditary angioneurotic edema: two genetic variants","volume":"148","author":"Rosen","year":"1965","journal-title":"Science"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.129.2.315","article-title":"The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor","volume":"129","author":"Ratnoff","year":"1969","journal-title":"J Exp Med"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00413358","article-title":"Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria","volume":"276","author":"Bork","year":"1984","journal-title":"Arch Dermatol Res"},{"issue":"5","key":"10.6061\/clinics\/2018\/e310_bib39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.anai.2013.12.023","article-title":"Current update on cellular and molecular mechanisms of hereditary angioedema","volume":"112","author":"Walford","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/ajplegacy.1949.156.2.261","article-title":"Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin","volume":"156","author":"Rocha e Silva","year":"1949","journal-title":"Am J Physiol"},{"key":"10.6061\/clinics\/2018\/e310_bib41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1113\/jphysiol.1960.sp006548","article-title":"Actions of pure bradykinin","volume":"153","author":"Elliott","year":"1960","journal-title":"J Physiol"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1006\/bbrc.1996.1417","article-title":"Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton","volume":"226","author":"Venema","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"issue":"9117","key":"10.6061\/clinics\/2018\/e310_bib43","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(97)09137-X","article-title":"Plasma bradykinin in angio-oedema","volume":"351","author":"Nussberger","year":"1998","journal-title":"Lancet"},{"issue":"8","key":"10.6061\/clinics\/2018\/e310_bib44","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJM200208223470820","article-title":"Bradykinin-mediated angioedema","volume":"347","author":"Nussberger","year":"2002","journal-title":"N Engl J Med"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib45","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0091-6749(99)70030-8","article-title":"Local bradykinin generation in hereditary angioedema","volume":"104","author":"Nussberger","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10.6061\/clinics\/2018\/e310_bib46","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI200214211","article-title":"Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor","volume":"109","author":"Han","year":"2002","journal-title":"J Clin Invest"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib47","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa0905079","article-title":"Ecallantide for the treatment of acute attacks in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bbrc.2006.03.092","article-title":"Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor","volume":"343","author":"Dewald","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib50","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jth.13194","article-title":"The contact activation and kallikrein\/kinin systems: pathophysiologic and physiologic activities","volume":"14","author":"Schmaier","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib51","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1086\/509899","article-title":"Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III","volume":"79","author":"Cichon","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"8","key":"10.6061\/clinics\/2018\/e310_bib52","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1172\/JCI77139","article-title":"Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III","volume":"125","author":"Bj\u00f6rkqvist","year":"2015","journal-title":"J Clin Invest"},{"issue":"5","key":"10.6061\/clinics\/2018\/e310_bib53","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jaci.2016.02.021","article-title":"Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations","volume":"138","author":"de Maat","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"10.6061\/clinics\/2018\/e310_bib54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/OGX.0000000000000457","article-title":"The complex interaction between polycystic ovary syndrome and hereditary angioedema: case reports and review of the literature","volume":"72","author":"Iahn-Aun","year":"2017","journal-title":"Obstet Gynecol Surv"},{"issue":"1-2","key":"10.6061\/clinics\/2018\/e310_bib55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0167-4781(93)90294-N","article-title":"The 5\u2019 sequence of human factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes","volume":"1172","author":"Citarella","year":"1993","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.6061\/clinics\/2018\/e310_bib56","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/sj.bjp.0701255","article-title":"Regulation of bradykinin B2-receptor expression by oestrogen","volume":"121","author":"Madeddu","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0167-4781(92)90069-C","article-title":"Differential regulation of kininogen gene expression by estrogen and progesterone in vivo","volume":"1131","author":"Chen","year":"1992","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.6061\/clinics\/2018\/e310_bib58","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1081-1206(10)61089-7","article-title":"Acute pancreatitis due to hereditary angioedema","volume":"97","author":"Matesic","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib59","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jaip.2014.08.002","article-title":"Comparison of chromogenic and ELISA functional C1 inhibitor tests in diagnosing hereditary angioedema","volume":"3","author":"Li","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"1-2","key":"10.6061\/clinics\/2018\/e310_bib60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jim.2008.06.004","article-title":"Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations","volume":"338","author":"Wagenaar-Bos","year":"2008","journal-title":"J Immunol Methods"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib61","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jaci.2007.06.026","article-title":"Hereditary angioedema: a decade of human C1-inhibitor concentrate therapy","volume":"120","author":"Farkas","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"10.6061\/clinics\/2018\/e310_bib62","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4065\/81.7.958","article-title":"Genetic test indications and interpretations in patients with hereditary angioedema","volume":"81","author":"Weiler","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib63","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jaci.2011.11.025","article-title":"International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency","volume":"129","author":"Caballero","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib64","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.clim.2013.08.001","article-title":"Novel duplication in the F12 gene in a patient with recurrent angioedema","volume":"149","author":"Kiss","year":"2013","journal-title":"Clin Immunol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e310_bib65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clim.2011.07.002","article-title":"A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor","volume":"141","author":"Bork","year":"2011","journal-title":"Clin Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib66","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12016-016-8539-6","article-title":"\u201cNuts and Bolts\u201d of Laboratory Evaluation of Angioedema","volume":"51","author":"Farkas","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"issue":"7","key":"10.6061\/clinics\/2018\/e310_bib67","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/all.12313","article-title":"The EAACI\/GA(2) Len\/EDF\/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update","volume":"69","author":"Zuberbier","year":"2014","journal-title":"Allergy"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib68","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/HYPERTENSIONAHA.108.110270","article-title":"Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors","volume":"51","author":"Miller","year":"2008","journal-title":"Hypertension"},{"issue":"14","key":"10.6061\/clinics\/2018\/e310_bib69","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.165.14.1637","article-title":"Incidence and characteristics of angioedema associated with enalapril","volume":"165","author":"Kostis","year":"2005","journal-title":"Arch Intern Med"},{"issue":"11","key":"10.6061\/clinics\/2018\/e310_bib70","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1097\/HJH.0b013e32834b4b9b","article-title":"Long-term follow-up of 111 patients with angiotensin-converting enzyme inhibitor-related angioedema","volume":"29","author":"Beltrami","year":"2011","journal-title":"J Hypertens"},{"issue":"3","key":"10.6061\/clinics\/2018\/e310_bib71","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.amjcard.2012.03.034","article-title":"Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors","volume":"110","author":"Makani","year":"2012","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib72","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V48.4.567.567","article-title":"Acquired angioedema with lymphoproliferative disorder: association of C1 inhibitor deficiency with cellular abnormality","volume":"48","author":"Schreiber","year":"1976","journal-title":"Blood"},{"issue":"9","key":"10.6061\/clinics\/2018\/e310_bib73","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.4049\/jimmunol.152.9.4680","article-title":"Acquired C1 inhibitor deficiency as a result of an autoantibody to the reactive center region of C1 inhibitor","volume":"152","author":"Mandle","year":"1994","journal-title":"J Immunol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e310_bib74","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.iac.2006.08.002","article-title":"Acquired deficiency of the inhibitor of the first complement component: presentation, diagnosis, course, and conventional management","volume":"26","author":"Zingale","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"issue":"6","key":"10.6061\/clinics\/2018\/e310_bib75","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2013.03.034","article-title":"A focused parameter update: hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor-associated angioedema","volume":"131","author":"Zuraw","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e310_bib76","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1172\/JCI112610","article-title":"Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients","volume":"78","author":"Zuraw","year":"1986","journal-title":"J Clin Invest"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222005518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222005518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:55:53Z","timestamp":1761720953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222005518"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322018000100303&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/brazilian-guidelines-for-hereditary-angioedema-management-2017-update-part-1-definition-classification-and-diagnosis\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":76,"alternative-id":["S1807593222005518"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2018\/e310","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2018\/e310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e310"}}