{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:06:28Z","timestamp":1790240788442,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":310,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2019]]},"DOI":"10.6061\/clinics\/2019\/e1200","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T15:31:10Z","timestamp":1572622270000},"page":"e1200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Expression of dNK cells and their cytokines in twin pregnancies with preeclampsia"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-0378","authenticated-orcid":false,"given":"Isabela K.R.","family":"Agra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6295-5089","authenticated-orcid":false,"given":"Adolfo W.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-4631","authenticated-orcid":false,"given":"Mara S.","family":"Hoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-8208","authenticated-orcid":false,"given":"Regina","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-3566","authenticated-orcid":false,"given":"Marcello P.","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-8069","authenticated-orcid":false,"given":"Rossana P.V.","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-2671","authenticated-orcid":false,"given":"Marcelo","family":"Zugaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6135-4844","authenticated-orcid":false,"given":"Maria L.","family":"Brizot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.6061\/clinics\/2019\/e1200_bib1","first-page":"e1","article-title":"ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1200_bib2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1200_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin Sci"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1200_bib4","doi-asserted-by":"crossref","first-page":"H541","DOI":"10.1152\/ajpheart.01113.2007","article-title":"Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction","volume":"294","author":"Gilbert","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.6061\/clinics\/2019\/e1200_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/1179545X17752325","article-title":"Preeclampsia: From Inflammation to Immunoregulation","volume":"11","author":"Cornelius","year":"2018","journal-title":"Clin Med Insights Blood Disord"},{"issue":"8","key":"10.6061\/clinics\/2019\/e1200_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11906-017-0757-7","article-title":"Pathophysiology and Current Clinical Management of Preeclampsia","volume":"19","author":"Amaral","year":"2017","journal-title":"Curr Hypertens Rep"},{"key":"10.6061\/clinics\/2019\/e1200_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2017.03.001","article-title":"Uterine NK cells and macrophages in pregnancy","volume":"56","author":"Faas","year":"2017","journal-title":"Placenta"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1200_bib8","doi-asserted-by":"crossref","first-page":"R490","DOI":"10.1152\/ajpregu.00176.2014","article-title":"Role of decidual natural killer cells, interleukin-15, and interferon-\u03b3 in placental development and preeclampsia","volume":"307","author":"Sones","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1200_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09629350220131962","article-title":"Cytokine secretion by decidual lymphocytes in transient hypertension of pregnancy and pre-eclampsia","volume":"11","author":"Wilczynski","year":"2002","journal-title":"Mediators Inflamm"},{"issue":"5-6","key":"10.6061\/clinics\/2019\/e1200_bib10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1600-0897.2006.00429.x","article-title":"Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia","volume":"56","author":"Bachmayer","year":"2006","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1200_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/REP-09-0007","article-title":"Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy","volume":"138","author":"Williams","year":"2009","journal-title":"Reproduction"},{"key":"10.6061\/clinics\/2019\/e1200_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1477-7827-7-132","article-title":"Specific subsets of immune cells in human decidua differ between normal pregnancy and preeclampsia. a prospective observational study","volume":"7","author":"Rieger","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1200_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00428-005-0107-z","article-title":"Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis","volume":"448","author":"Eide","year":"2006","journal-title":"Virchows Arch"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1200_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5144\/0256-4947.2000.4","article-title":"Interleukins in preeclampsia","volume":"20","author":"Olusi","year":"2000","journal-title":"Ann Saudi Med"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1200_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1701-2163(16)34098-1","article-title":"Elevated serum levels of interleukin-15, interleukin-16, and human chorionic gonadotropin in women with preeclampsia","volume":"31","author":"El-Baradie","year":"2009","journal-title":"J Obstet Gynaecol Can"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1200_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151535","article-title":"Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells","volume":"11","author":"Hromadnikova","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1200_bib17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.170.3.827","article-title":"Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes","volume":"170","author":"Kobayashi","year":"1989","journal-title":"J Exp Med"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1200_bib18","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.4049\/jimmunol.163.6.3491","article-title":"A deficiency of placental IL-10 in preeclampsia","volume":"163","author":"Hennessy","year":"1999","journal-title":"J Immunol"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1200_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/aji.12329","article-title":"Interleukin-10: a pleiotropic regulator in pregnancy","volume":"73","author":"Cheng","year":"2015","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1200_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jri.2011.01.009","article-title":"Vascular IL-10: a protective role in preeclampsia","volume":"88","author":"Kalkunte","year":"2011","journal-title":"J Reprod Immunol"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1200_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2013.02.027","article-title":"Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state","volume":"62","author":"Pinheiro","year":"2013","journal-title":"Cytokine"},{"issue":"9","key":"10.6061\/clinics\/2019\/e1200_bib22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1034\/j.1600-0412.2003.00206.x","article-title":"Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels","volume":"82","author":"Madazli","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1200_bib23","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0002-9378(00)70350-4","article-title":"Hypertensive disorders in twin versus singleton gestations. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"182","author":"Sibai","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1200_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001608","article-title":"Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women","volume":"3","author":"Neres","year":"2008","journal-title":"PLoS One"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1200_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004280050329","article-title":"Aberrant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia","volume":"434","author":"Stallmach","year":"1999","journal-title":"Virchows Arch"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1200_bib26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1095\/biolreprod.108.073353","article-title":"Interferon gamma in successful pregnancies","volume":"80","author":"Murphy","year":"2009","journal-title":"Biol Reprod"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:54:46Z","timestamp":1761720886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222007189"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322019000100295&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6820511\/","label":"PMC"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/expression-of-dnk-cells-and-their-cytokines-in-twin-pregnancies-with-preeclampsia\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":26,"alternative-id":["S1807593222007189"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1200","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of dNK cells and their cytokines in twin pregnancies with preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e1200"}}