{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:39:57Z","timestamp":1790487597198,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":328,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2019]]},"DOI":"10.6061\/clinics\/2019\/e1207","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T15:18:01Z","timestamp":1574954281000},"page":"e1207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Viscosupplementation improves pain, function and muscle strength, but not proprioception, in patients with knee osteoarthritis: a prospective randomized trial"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-6244","authenticated-orcid":false,"given":"Phelippe Augusto Valente","family":"Maia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-6121","authenticated-orcid":false,"given":"Victor Rodrigues Amaral","family":"Cossich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-0352","authenticated-orcid":false,"given":"Jos\u00e9 Inacio","family":"Salles-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-3779","authenticated-orcid":false,"given":"Diego Pinheiro","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-6403","authenticated-orcid":false,"given":"Eduardo Branco","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.6061\/clinics\/2019\/e1207_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.6061\/clinics\/2019\/e1207_bib2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.joca.2011.08.004","article-title":"Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey","volume":"19","author":"Guillemin","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1207_bib3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1589\/jpts.26.817","article-title":"Comparative study of hamstrings and quadriceps strengthening treatments in the management of knee osteoarthritis","volume":"26","author":"Al-Johani","year":"2014","journal-title":"J Phys Ther Sci"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1207_bib4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0736-0266(03)00052-4","article-title":"Quadriceps strength and volitional activation before and after total knee arthroplasty for osteoarthritis","volume":"21","author":"Stevens","year":"2003","journal-title":"J Orthop Res"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1207_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.semarthrit.2009.10.001","article-title":"Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives","volume":"40","author":"Rice","year":"2010","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1207_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s13075-014-0502-4","article-title":"Quadricep arthrogenic muscle inhibition: the effects of experimental knee joint effusion on motor cortex excitability","volume":"16","author":"Rice","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1590\/1413-785220172501165604","article-title":"Parqve: Project Arthritis Recovering Quality of Life Through Education: Two-Year Results","volume":"25","author":"Rezende","year":"2017","journal-title":"Acta Ortop Bras"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1207_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1749-6632.1955.tb42501.x","article-title":"The use of intra-articular hydrocortisone, its analogs and its higher esters in arthritis","volume":"61","author":"Hollander","year":"1955","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1207_bib9","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.arthro.2018.02.022","article-title":"Injections for Knee Osteoarthritis: Corticosteroids, Viscosupplementation, Platelet-Rich Plasma, and Autologous Stem Cells","volume":"34","author":"Levy","year":"2018","journal-title":"Arthroscopy"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1207_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1677\/joe.0.1690573","article-title":"Dexamethasone enhances SOX9 expression in chondrocytes","volume":"169","author":"Sekiya","year":"2001","journal-title":"J Endocrinol"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1207_bib11","first-page":"135","article-title":"Tratamento da osteoartrite do joelho","volume":"36","author":"Camanho","year":"2001","journal-title":"Rev Bras Ortop"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1207_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpain.2006.02.013","article-title":"Short-term efficacy of phar- macotherapeutic interventions in osteoarthritic knee pain: A meta-analysis of randomised placebo-controlled trials","volume":"11","author":"Bjordal","year":"2007","journal-title":"Eur J Pain"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1207_bib13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11999-012-2659-y","article-title":"Adding triamcinolone improves viscosupplementation: a randomized clinical trial","volume":"471","author":"de Campos","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"11","key":"10.6061\/clinics\/2019\/e1207_bib14","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1136\/ard.2011.152017","article-title":"A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project","volume":"70","author":"Navarro-Sarabia","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"10.6061\/clinics\/2019\/e1207_bib15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.6061\/clinics\/2019\/e1207_bib16","series-title":"Tradu\u00e7\u00e3o e valida\u00e7\u00e3o do question\u00e1rio de qualidade de vida espec\u00edfico para osteoartrose WOMAC (Western Ontario McMaster Universities) para a l\u00edngua portuguesa","first-page":"103","author":"Fernandes","year":"2003"},{"key":"10.6061\/clinics\/2019\/e1207_bib17","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.6061\/clinics\/2019\/e1207_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijsu.2017.01.087","article-title":"Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: A meta-analysis","volume":"39","author":"He","year":"2017","journal-title":"Int J Surg"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1207_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.semarthrit.2013.11.012","article-title":"A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative","volume":"43","author":"Nelson","year":"2014","journal-title":"Semin Arthritis Rheum"},{"issue":"4 Suppl","key":"10.6061\/clinics\/2019\/e1207_bib20","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.semarthrit.2015.11.008","article-title":"Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys","volume":"45","author":"Maheu","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"10.6061\/clinics\/2019\/e1207_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1471-2474-12-221","article-title":"Intra\u2010articular injections of sodium hyaluronate (Hyalgan\u00ae) in osteoarthritis of the knee. A randomized, controlled, double\u2010blind, multicenter trial in the Asian population","volume":"12","author":"Huang","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"issue":"7","key":"10.6061\/clinics\/2019\/e1207_bib22","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00167-013-2438-7","article-title":"Intra-articular hylastan versus steroid for knee osteoarthritis","volume":"22","author":"Housman","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1207_bib23","first-page":"337","article-title":"[The use of arthroscopic debridement and viscosupplementation in knee osteoarthritis]","volume":"41","author":"Ulucay","year":"2007","journal-title":"Acta Orthop Traumatol Turc"},{"issue":"12","key":"10.6061\/clinics\/2019\/e1207_bib24","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1002\/art.24925","article-title":"Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis","volume":"61","author":"Banuru","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00776-009-1421-0","article-title":"Clinical and biochemical characteristics after intra-articular injection for the treatment of osteoarthritis of the knee: prospective randomized study of sodium hyaluronate and corticosteroid","volume":"15","author":"Shimizu","year":"2010","journal-title":"J Orthop Sci"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joca.2013.10.009","article-title":"NASHA hyaluronic acid vs. methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial","volume":"22","author":"Leighton","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.6061\/clinics\/2019\/e1207_bib27","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s00264-017-3625-9","article-title":"Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial","volume":"41","author":"Campos","year":"2017","journal-title":"Int Orthop"},{"issue":"7","key":"10.6061\/clinics\/2019\/e1207_bib28","first-page":"311","article-title":"Can Hylan G-F 20 with corticosteroid meet the expectations of osteoarthritis patients?","volume":"41","author":"Briggs","year":"2012","journal-title":"Am J Orthop"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1207_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00296-005-0584-z","article-title":"The safety and efficacy of intraarticular hyaluronan with\/without corticosteroid in knee osteoarthritis: 1-year, single-blind, randomized study","volume":"26","author":"Ozturk","year":"2006","journal-title":"Rheumatol Int"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1207_bib30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0003-9993(00)90041-8","article-title":"Viscosupplementation effect on proprioception in the osteoarthritic knee","volume":"81","author":"Payne","year":"2000","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/BMR-2009-0207","article-title":"The effect of viscosupplementation on neuromuscular control of the knee in patients with osteoarthritis","volume":"22","author":"Diracoglu","year":"2009","journal-title":"J Back Musculoskelet Rehabil"},{"key":"10.6061\/clinics\/2019\/e1207_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/815184","article-title":"Effect of intra-articular hyaluronic injection on postural stability and risk of fall in patients with bilateral knee osteoarthritis","volume":"2014","author":"Khalaj","year":"2014","journal-title":"ScientificWorldJournal"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1207_bib33","first-page":"171","article-title":"Knee joint effusion and quadriceps reflex inhibition in man","volume":"65","author":"Spencer","year":"1984","journal-title":"Arch Phys Med Rehabil"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1207_bib34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1113\/expphysiol.1988.sp003147","article-title":"Pressures in normal and acutely distended human knee joints and effects on quadriceps maximal voluntary contractions","volume":"73","author":"Wood","year":"1988","journal-title":"Q J Exp Physiol"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13075-017-1477-8","article-title":"Is the relationship between increased knee muscle strength and improved physical function following physical exercise dependent on baseline physical function status?","volume":"19","author":"Hall","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.6061\/clinics\/2019\/e1207_bib36","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1589\/jpts.27.2439","article-title":"Effects of proprioceptive circuit exercise on knee joint pain and muscle function in patients with knee osteoarthritis","volume":"27","author":"Ju","year":"2015","journal-title":"J Phys Ther Sci"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1207_bib37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.rbo.2017.01.002","article-title":"Comparative analysis of quadriceps and hamstrings strength in knee osteoarthritis before and after total knee arthroplasty: a cross-sectional study","volume":"53","author":"Cavanellas","year":"2018","journal-title":"Rev Bras Ortop"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1207_bib38","first-page":"35","article-title":"Pain and its relationship with muscle strength and proprioception in knee OA: results of an 8-week home exercise pilot study","volume":"8","author":"Shakoor","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"11","key":"10.6061\/clinics\/2019\/e1207_bib39","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1007\/s00296-012-2480-7","article-title":"The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: a systematic review and meta-analysis","volume":"32","author":"Smith","year":"2012","journal-title":"Rheumatol Int"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:52:16Z","timestamp":1761720736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222007207"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322019000100200&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6844143\/","label":"PMC"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/viscosupplementation-improves-pain-function-and-muscle-strength-but-not-proprioception-in-patients-with-knee-osteoarthritis-a-prospective-randomized-trial\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":39,"alternative-id":["S1807593222007207"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1207","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viscosupplementation improves pain, function and muscle strength, but not proprioception, in patients with knee osteoarthritis: a prospective randomized trial","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e1207"}}