{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:58:43Z","timestamp":1790510323907,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":283,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2021]]},"DOI":"10.6061\/clinics\/2021\/e2971","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T18:23:35Z","timestamp":1634581415000},"page":"e2971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Comparison of hormonal receptor expression and HER2 status between circulating tumor cells and breast cancer metastases"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-3377","authenticated-orcid":false,"given":"Solange Moraes","family":"Sanches","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-2026","authenticated-orcid":false,"given":"Alexcia Camila","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-5863","authenticated-orcid":false,"given":"Vinicius Fernando","family":"Calsavara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-5328","authenticated-orcid":false,"given":"Paula Nicole Vieira Pinto","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-8420","authenticated-orcid":false,"given":"Ludmilla Thome Domingos","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib1","first-page":"7","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"Suppl 3","key":"10.6061\/clinics\/2021\/e2971_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1634\/theoncologist.10-90003-20","article-title":"Extending survival with chemotherapy in metastatic breast cancer","volume":"10","author":"O\u2019Shaughnessy","year":"2005","journal-title":"Oncologist"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/bcr3630","article-title":"Biopsy confirmation of metastatic sites in breast cancer patients: clinical impact and future perspectives","volume":"16","author":"Criscitiello","year":"2014","journal-title":"Breast Cancer Res"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1634\/theoncologist.2012-0350","article-title":"Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis","volume":"18","author":"Curtit","year":"2013","journal-title":"Oncologist"},{"issue":"8","key":"10.6061\/clinics\/2021\/e2971_bib5","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ctrv.2013.05.003","article-title":"HER2 discordance between primary and metastatic breast cancer: assessing the clinical impact","volume":"39","author":"Turner","year":"2013","journal-title":"Cancer Treat Rev"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib6","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ctrv.2011.11.006","article-title":"Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies","volume":"38","author":"Amir","year":"2012","journal-title":"Cancer Treat Rev"},{"issue":"8","key":"10.6061\/clinics\/2021\/e2971_bib7","first-page":"2275","article-title":"Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational Study","volume":"18","author":"Ried","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3-4","key":"10.6061\/clinics\/2021\/e2971_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000452556","article-title":"Evaluation of Isolation Methods for Circulating Tumor Cells (CTCs)","volume":"40","author":"Kallergi","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"10.6061\/clinics\/2021\/e2971_bib9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJMoa040766","article-title":"Circulating tumor cells, disease progression, and survival in metastatic breast cancer","volume":"351","author":"Cristofanilli","year":"2004","journal-title":"N Engl J Med"},{"issue":"14 Pt 1","key":"10.6061\/clinics\/2021\/e2971_bib10","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1158\/1078-0432.CCR-05-2821","article-title":"Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival","volume":"12","author":"Hayes","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"31","key":"10.6061\/clinics\/2021\/e2971_bib11","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1200\/JCO.2014.56.2561","article-title":"Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500","volume":"32","author":"Smerage","year":"2014","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/jamaoncol.2020.5660","article-title":"Efficacy of Circulating Tumor Cell Count-Driven vs Clinician-Driven First-line Therapy Choice in Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer: The STIC CTC Randomized Clinical Trial","volume":"7","author":"Bidard","year":"2021","journal-title":"JAMA Oncol"},{"issue":"15_suppl","key":"10.6061\/clinics\/2021\/e2971_bib13","article-title":"The impact of circulating tumor cells (CTCs) detection in metastatic breast cancer (MBC): Implications of \u201cindolent\u201d stage IV disease (Stage IV indolent)","author":"Davis","year":"2018","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.6061\/clinics\/2021\/e2971_bib14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S1470-2045(12)70209-7","article-title":"Circulating tumour cells in non-metastatic breast cancer: a prospective study","volume":"13","author":"Lucci","year":"2012","journal-title":"Lancet Oncol"},{"issue":"10","key":"10.6061\/clinics\/2021\/e2971_bib15","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1158\/1078-0432.CCR-15-1603","article-title":"Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer","volume":"22","author":"Janni","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.6061\/clinics\/2021\/e2971_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju066","article-title":"Circulating tumor cells predict survival in early average-to-high risk breast cancer patients","volume":"106","author":"Rack","year":"2014","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"10.6061\/clinics\/2021\/e2971_bib17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1001\/jamaoncol.2018.2574","article-title":"Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial","volume":"4","author":"Sparano","year":"2018","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00404-015-3879-7","article-title":"Therapeutic intervention based on circulating tumor cell phenotype in metastatic breast cancer: concept of the DETECT study program","volume":"293","author":"Schramm","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"10.6061\/clinics\/2021\/e2971_bib19","author":"National Comprehensive Cancer Network, Breast Cancer (Version 1.2021)"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169427","article-title":"Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion","volume":"12","author":"Laget","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/bjc.2011.294","article-title":"A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas","volume":"105","author":"Farace","year":"2011","journal-title":"Br J Cancer"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/bcr2224","article-title":"Transforming growth factor-beta in breast cancer: too much, too late","volume":"11","author":"Barcellos-Hoff","year":"2009","journal-title":"Breast Cancer Res"},{"key":"10.6061\/clinics\/2021\/e2971_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/141747","article-title":"Two faces of TGF-beta1 in breast cancer","volume":"2014","author":"Zarzynska","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"12","key":"10.6061\/clinics\/2021\/e2971_bib24","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1200\/JCO.19.02309","article-title":"Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO\/CAP Guideline Update","volume":"38","author":"Allison","year":"2020","journal-title":"J Clin Oncol"},{"issue":"20","key":"10.6061\/clinics\/2021\/e2971_bib25","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1200\/JCO.2018.77.8738","article-title":"Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology\/College of American Pathologists Clinical Practice Guideline Focused Update","volume":"36","author":"Wolff","year":"2018","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/JTO.0b013e31823c5c16","article-title":"Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches","volume":"7","author":"Krebs","year":"2012","journal-title":"J Thorac Oncol"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2307\/2532740","article-title":"Maximally Selected Rank Statistics","volume":"48","author":"Lausen","year":"1992","journal-title":"Biometrics"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib28","article-title":"Genomics alterations of metastatic and primary tissues across 15 cancer types","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11912-010-0137-9","article-title":"The need to examine metastatic tissue at the time of progression of breast cancer: is re-biopsy a necessity or a luxury?","volume":"13","author":"Khasraw","year":"2011","journal-title":"Curr Oncol Rep"},{"issue":"4","key":"10.6061\/clinics\/2021\/e2971_bib30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","article-title":"Emerging Biological Principles of Metastasis","volume":"168","author":"Lambert","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.6061\/clinics\/2021\/e2971_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/diagnostics8030059","article-title":"The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy","volume":"8","author":"Leone","year":"2018","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsamd.2019.01.006","article-title":"Novel approaches in cancer management with circulating tumor cell clusters","volume":"4","author":"Rostami","year":"2019","journal-title":"J Sci Adv Mater Devices"},{"issue":"36","key":"10.6061\/clinics\/2021\/e2971_bib33","doi-asserted-by":"crossref","first-page":"24561","DOI":"10.18632\/oncotarget.25337","article-title":"Circulating tumor cells in clinical research and monitoring patients with colorectal cancer","volume":"9","author":"Burz","year":"2018","journal-title":"Oncotarget"},{"issue":"11","key":"10.6061\/clinics\/2021\/e2971_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv250","article-title":"Circulating Tumor Cells and Recurrence After Primary Systemic Therapy in Stage III Inflammatory Breast Cancer","volume":"107","author":"Hall","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10549-012-2382-0","article-title":"The prognostic impact of circulating tumor cells in subtypes of metastatic breast cancer","volume":"137","author":"Wallwiener","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib36","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1007\/s13277-014-1731-5","article-title":"Prognostic role of circulating tumor cells and disseminated tumor cells in patients with prostate cancer: a systematic review and meta-analysis","volume":"35","author":"Ma","year":"2014","journal-title":"Tumour Biol"},{"issue":"15","key":"10.6061\/clinics\/2021\/e2971_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.21037\/atm.2019.03.28","article-title":"Liquid biopsy for lung cancers: an update on recent developments","volume":"7","author":"Revelo","year":"2019","journal-title":"Ann Transl Med"},{"issue":"8","key":"10.6061\/clinics\/2021\/e2971_bib38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.6004\/jnccn.2013.0118","article-title":"Analysis of circulating tumor cells in breast cancer","volume":"11","author":"Eroglu","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"issue":"9","key":"10.6061\/clinics\/2021\/e2971_bib39","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1001\/jamaoncol.2020.2295","article-title":"Association of Circulating Tumor DNA and Circulating Tumor Cells After Neoadjuvant Chemotherapy With Disease Recurrence in Patients With Triple-Negative Breast Cancer: Preplanned Secondary Analysis of the BRE12-158 Randomized Clinical Trial","volume":"6","author":"Radovich","year":"2020","journal-title":"JAMA Oncol"},{"issue":"21","key":"10.6061\/clinics\/2021\/e2971_bib40","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1158\/1078-0432.CCR-05-1769","article-title":"Circulating tumor cells versus imaging\u2013predicting overall survival in metastatic breast cancer","volume":"12","author":"Budd","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.6061\/clinics\/2021\/e2971_bib41","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/annonc\/mdr434","article-title":"Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy","volume":"23","author":"Giordano","year":"2012","journal-title":"Ann Oncol"},{"issue":"12","key":"10.6061\/clinics\/2021\/e2971_bib42","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/annonc\/mdt348","article-title":"Circulating tumor cells and brain metastasis outcome in patients with HER2-positive breast cancer: the LANDSCAPE trial","volume":"24","author":"Pierga","year":"2013","journal-title":"Ann Oncol"},{"issue":"7","key":"10.6061\/clinics\/2021\/e2971_bib43","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.21037\/tcr-19-2662","article-title":"Clinical value and feasibility of ISET in detecting circulating tumor cells in early breast cancer","volume":"9","author":"Zeng","year":"2020","journal-title":"Transl Cancer Res"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/cancers12020487","article-title":"Circulating Tumor Cells and Metabolic Parameters in NSCLC Patients Treated with Checkpoint Inhibitors","volume":"12","author":"Castello","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.6061\/clinics\/2021\/e2971_bib45","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1200\/JCO.2010.33.3716","article-title":"Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer","volume":"30","author":"Hou","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.6061\/clinics\/2021\/e2971_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41241-018-0059-7","article-title":"Circulating tumor cells as marker of poor prognosis in metastatic lung cancer: a pilot study","volume":"38","author":"Diaz","year":"2018","journal-title":"Appl Cancer Res"},{"issue":"7","key":"10.6061\/clinics\/2021\/e2971_bib47","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/ijc.25819","article-title":"Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay\u2122 and the isolation by size of epithelial tumor cell method","volume":"129","author":"Hofman","year":"2011","journal-title":"Int J Cancer"},{"issue":"4","key":"10.6061\/clinics\/2021\/e2971_bib48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1158\/1078-0432.CCR-10-0445","article-title":"Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker","volume":"17","author":"Hofman","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.6061\/clinics\/2021\/e2971_bib49","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.2147\/OTT.S115268","article-title":"Early detection of poor outcome in patients with metastatic colorectal cancer: tumor kinetics evaluated by circulating tumor cells","volume":"9","author":"Souza","year":"2016","journal-title":"Onco Targets Ther"},{"issue":"5","key":"10.6061\/clinics\/2021\/e2971_bib50","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00280-018-3666-9","article-title":"Prognostic significance of CEACAM5mRNA-positive circulating tumor cells in patients with metastatic colorectal cancer","volume":"82","author":"Messaritakis","year":"2018","journal-title":"Cancer Chemother Pharmacol"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib51","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/SLA.0000000000001600","article-title":"Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma","volume":"264","author":"Poruk","year":"2016","journal-title":"Ann Surg"},{"issue":"11","key":"10.6061\/clinics\/2021\/e2971_bib52","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1158\/1078-0432.CCR-16-1467","article-title":"Circulating Tumor Cells Expressing Markers of Tumor-Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma","volume":"23","author":"Poruk","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.6061\/clinics\/2021\/e2971_bib53","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.20091","article-title":"Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer","volume":"39","author":"Vona","year":"2004","journal-title":"Hepatology"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib54","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/15384047.2018.1433498","article-title":"EGFR expression in circulating tumor cells from high-grade metastatic soft tissue sarcomas","volume":"19","author":"Braun","year":"2018","journal-title":"Cancer Biol Ther"},{"issue":"9","key":"10.6061\/clinics\/2021\/e2971_bib55","doi-asserted-by":"crossref","first-page":"e854","DOI":"10.1634\/theoncologist.2018-0741","article-title":"The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer","volume":"24","author":"Abdallah","year":"2019","journal-title":"Oncologist"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ijc.25690","article-title":"Characterization of metastatic breast cancer patients with nondetectable circulating tumor cells","volume":"129","author":"Mego","year":"2011","journal-title":"Int J Cancer"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib57","doi-asserted-by":"crossref","DOI":"10.1590\/0102-672020190001e1433","article-title":"Evaluating MMP-2 and TGF\u00df-RI expression in circulating tumor cells of pancreatic cancer patients and their correlation with clinical evolution","volume":"32","author":"Gasparini-Junior","year":"2019","journal-title":"Arq Bras Cir Dig"},{"issue":"suppl3","key":"10.6061\/clinics\/2021\/e2971_bib58","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1016\/j.ijrobp.2020.07.958","article-title":"Final Results of a Prospective Correlative Analysis of Circulating Tumor Cells and Early Distant Brain Failure after Stereotactic Radiotherapy\/Radiosurgery for Brain Metastases of Breast Cancer","volume":"108","author":"Castro","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.6061\/clinics\/2021\/e2971_bib59","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1111\/cas.13985","article-title":"A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients","volume":"110","author":"Zmetakova","year":"2019","journal-title":"Cancer Sci"},{"issue":"8","key":"10.6061\/clinics\/2021\/e2971_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081836","article-title":"Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells","volume":"9","author":"Eslami-S","year":"2020","journal-title":"Cells"},{"issue":"17","key":"10.6061\/clinics\/2021\/e2971_bib61","doi-asserted-by":"crossref","first-page":"24677","DOI":"10.18632\/oncotarget.8250","article-title":"Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer","volume":"7","author":"Hyun","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.6061\/clinics\/2021\/e2971_bib62","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/bcr2912","article-title":"The microenvironment in breast cancer progression: biology and implications for treatment","volume":"13","author":"Place","year":"2011","journal-title":"Breast Cancer Res"},{"issue":"3","key":"10.6061\/clinics\/2021\/e2971_bib63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/path.2278","article-title":"Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome","volume":"214","author":"Bergamaschi","year":"2008","journal-title":"J Pathol"},{"issue":"1","key":"10.6061\/clinics\/2021\/e2971_bib64","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nm.1908","article-title":"A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer","volume":"15","author":"Farmer","year":"2009","journal-title":"Nat Med"},{"key":"10.6061\/clinics\/2021\/e2971_bib65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jss.2019.04.090","article-title":"Circulating Tumor Cells and Transforming Growth Factor Beta in Resected Pancreatic Adenocarcinoma","volume":"243","author":"Vicente","year":"2019","journal-title":"J Surg Res"},{"issue":"4","key":"10.6061\/clinics\/2021\/e2971_bib66","first-page":"1491","article-title":"Circulating levels of transforming growth factor-\u03b2eta (TGF-\u03b2) and chemokine (C-X-C motif) ligand-1 (CXCL1) as predictors of distant seeding of circulating tumor cells in patients with metastatic breast cancer","volume":"33","author":"Divella","year":"2013","journal-title":"Anticancer Res"},{"issue":"11","key":"10.6061\/clinics\/2021\/e2971_bib67","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/hed.24899","article-title":"Evaluation of incidence, significance, and prognostic role of circulating tumor microemboli and transforming growth factor-\u03b2 receptor I in head and neck cancer","volume":"39","author":"Fanelli","year":"2017","journal-title":"Head Neck"},{"issue":"3","key":"10.6061\/clinics\/2021\/e2971_bib68","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1172\/JCI65416","article-title":"TGF-\u03b2 inhibition enhances chemotherapy action against triple-negative breast cancer","volume":"123","author":"Bhola","year":"2013","journal-title":"J Clin Invest"},{"issue":"2","key":"10.6061\/clinics\/2021\/e2971_bib69","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa226","article-title":"A Positive Feedback Loop Between TGF\u03b2 and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance","volume":"162","author":"Rosas","year":"2021","journal-title":"Endocrinology"},{"key":"10.6061\/clinics\/2021\/e2971_bib70","first-page":"4479","article-title":"Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway","volume":"9","author":"Herbertz","year":"2015","journal-title":"Drug Des Devel Ther"},{"issue":"10","key":"10.6061\/clinics\/2021\/e2971_bib71","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41416-018-0246-z","article-title":"Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer","volume":"119","author":"Melisi","year":"2018","journal-title":"Br J Cancer"},{"key":"10.6061\/clinics\/2021\/e2971_bib72","author":"Abramson"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322200196X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322200196X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:06:59Z","timestamp":1761721619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S180759322200196X"},"secondary":[{"URL":"https:\/\/www.scielo.br\/j\/clin\/a\/YMH8NJddTXX9bQHbtDsqzRJ\/?lang=en","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8478133\/","label":"PMC"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/comparison-of-hormonal-receptor-expression-and-her2-status-between-circulating-tumor-cells-and-breast-cancer-metastases\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":72,"alternative-id":["S180759322200196X"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2021\/e2971","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of hormonal receptor expression and HER2 status between circulating tumor cells and breast cancer metastases","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2021\/e2971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e2971"}}