{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:03:36Z","timestamp":1768892616662,"version":"3.49.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.6061\/clinics\/2012(sup01)14","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T17:56:33Z","timestamp":1335290193000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"S1","title":["Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2"],"prefix":"10.1016","volume":"67","author":[{"given":"Simona M.","family":"Wagner","sequence":"first","affiliation":[]},{"given":"ShuJun","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Adrian C.","family":"Nicolescu","sequence":"additional","affiliation":[]},{"given":"Lois M","family":"Mulligan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cncr.10205","article-title":"Medullary thyroid carcinoma as part of a multiple endocrine neoplasia type 2B syndrome: influence of the stage on the clinical course","volume":"94","author":"Leboulleux","year":"2002","journal-title":"Cancer"},{"issue":"12","key":"10.6061\/clinics\/2012(Sup01)14_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00268-004-7637-4","article-title":"Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease","volume":"28","author":"Brauckhoff","year":"2004","journal-title":"World J Surg"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.surg.2008.08.028","article-title":"Premonitory symptoms preceding metastatic medullary thyroid cancer in MEN 2B: An exploratory analysis","volume":"144","author":"Brauckhoff","year":"2008","journal-title":"Surgery"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ng0194-70","article-title":"Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC","volume":"6","author":"Mulligan","year":"1994","journal-title":"Nature Genet"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/363458a0","article-title":"Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature"},{"issue":"7","key":"10.6061\/clinics\/2012(Sup01)14_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/hmg\/2.7.851","article-title":"Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC","volume":"2","author":"Donis-Keller","year":"1993","journal-title":"Hum Mol Genet"},{"issue":"12","key":"10.6061\/clinics\/2012(Sup01)14_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib8","first-page":"612","article-title":"Medullary thyroid cancer: management guidelines of the American Thyroid Association","volume":"19","author":"Kloos","year":"2009","journal-title":"Thyroid"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/dev.119.4.1005","article-title":"Expression of the c-ret proto-oncogene during mouse embryogenesis","volume":"119","author":"Pachnis","year":"1993","journal-title":"Development"},{"issue":"5","key":"10.6061\/clinics\/2012(Sup01)14_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<481::AID-AJMG8>3.0.CO;2-6","article-title":"Expression of the RET proto-oncogene in human embryos","volume":"80","author":"Attie-Bitach","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib11","first-page":"85","article-title":"ret transforming gene encodes a fusion protein homologous to tyrosine kinases","volume":"7","author":"Takahashi","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib12","first-page":"8","article-title":"Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains","volume":"3","author":"Takahashi","year":"1988","journal-title":"Oncogene"},{"issue":"4861","key":"10.6061\/clinics\/2012(Sup01)14_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.3291115","article-title":"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains","volume":"241","author":"Hanks","year":"1988","journal-title":"Science"},{"issue":"50","key":"10.6061\/clinics\/2012(Sup01)14_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1074\/jbc.M802543200","article-title":"The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding","volume":"283","author":"Parkash","year":"2008","journal-title":"J Biol Chem"},{"issue":"11","key":"10.6061\/clinics\/2012(Sup01)14_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nchembio823","article-title":"Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret","volume":"2","author":"Schlee","year":"2006","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0896-6273(01)00188-X","article-title":"Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts","volume":"29","author":"Paratcha","year":"2001","journal-title":"Neuron"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1586\/epr.11.2","article-title":"Lipid rafts: signaling and sorting platforms of cells and their roles in cancer","volume":"8","author":"Staubach","year":"2011","journal-title":"Expert Rev Proteomics"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cytogfr.2005.05.010","article-title":"RET tyrosine kinase signaling in development and cancer","volume":"16","author":"Arighi","year":"2005","journal-title":"Cytokine and Growth Factor Reviews"},{"issue":"19","key":"10.6061\/clinics\/2012(Sup01)14_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1074\/jbc.M110.168500","article-title":"Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism","volume":"286","author":"Plaza-Menacho","year":"2011","journal-title":"J Biol Chem"},{"issue":"4","key":"10.6061\/clinics\/2012(Sup01)14_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/humu.20928","article-title":"Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype\/phenotype correlations","volume":"30","author":"Margraf","year":"2009","journal-title":"Hum Mutat"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2265.2007.03153.x","article-title":"Familial prevalence and age of RET germline mutations: implications for screening","volume":"69","author":"Machens","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10689-010-9320-2","article-title":"Update multiple endocrine neoplasia type 2","volume":"9","author":"Raue","year":"2010","journal-title":"Fam Cancer"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.soc.2008.08.002","article-title":"Thyroid cancer genetics: multiple endocrine neoplasia type 2, non-medullary familial thyroid cancer, and familial syndromes associated with thyroid cancer","volume":"18","author":"Richards","year":"2009","journal-title":"Surg Oncol Clin N Am"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib24","first-page":"4","article-title":"A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A","volume":"83","author":"Berndt","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.6061\/clinics\/2012(Sup01)14_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.surg.2007.12.015","article-title":"Pheochromocytoma penetrance varies by RET mutation in MEN 2A","volume":"143","author":"Machens","year":"2008","journal-title":"Surgery"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jama.1996.03540190047028","article-title":"The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET Mutation Consortium","volume":"276","author":"Eng","year":"1996","journal-title":"JAMA"},{"issue":"4","key":"10.6061\/clinics\/2012(Sup01)14_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/archsurg.138.4.409","article-title":"Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship","volume":"138","author":"Yip","year":"2003","journal-title":"Arch Surg"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.surg.2007.09.013","article-title":"Pheochromocytoma penetrance varies by RET mutation in MEN 2A","volume":"142","author":"Quayle","year":"2007","journal-title":"Surgery"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1542\/peds.111.2.e132","article-title":"Review of multiple endocrine neoplasia type 2A in children: therapeutic results of early thyroidectomy and prognostic value of codon analysis","volume":"111","author":"Szinnai","year":"2003","journal-title":"Pediatrics"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1210\/jc.2002-021422","article-title":"RET codon 634 mutations in multiple endocrine neoplasia type 2: variable clinical features and clinical outcome","volume":"88","author":"Punales","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.6061\/clinics\/2012(Sup01)14_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00268-008-9734-2","article-title":"Pheochromocytoma in MEN 2A syndrome. Study of 54 patients","volume":"32","author":"Rodriguez","year":"2008","journal-title":"World J Surg"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cellsig.2004.10.012","article-title":"Direct interactions among Ret, GDNF and GFRalpha1 molecules reveal new insights into the assembly of a functional three-protein complex","volume":"17","author":"Amoresano","year":"2005","journal-title":"Cell Signal"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib33","first-page":"5","article-title":"The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype","volume":"57","author":"Carlomagno","year":"1997","journal-title":"Cancer Res"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.onc.1202202","article-title":"Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines","volume":"17","author":"Chappuis-Flament","year":"1998","journal-title":"Oncogene"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib35","first-page":"2","article-title":"Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype","volume":"57","author":"Ito","year":"1997","journal-title":"Cancer Res"},{"issue":"44","key":"10.6061\/clinics\/2012(Sup01)14_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1074\/jbc.M505707200","article-title":"Inducible dimerization of RET reveals a specific AKT deregulation in oncogenic signalling","volume":"280","author":"Freche","year":"2005","journal-title":"J Biol Chem"},{"issue":"11","key":"10.6061\/clinics\/2012(Sup01)14_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/0008-5472.CAN-08-4425","article-title":"Transcript level modulates the inherent oncogenicity of RET\/PTC oncoproteins","volume":"69","author":"Richardson","year":"2009","journal-title":"Cancer Res"},{"issue":"14","key":"10.6061\/clinics\/2012(Sup01)14_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1074\/jbc.M500507200","article-title":"Distinct turnover of alternatively-spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase","volume":"280","author":"Scott","year":"2005","journal-title":"J Biol Chem"},{"issue":"7","key":"10.6061\/clinics\/2012(Sup01)14_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cellsig.2004.01.002","article-title":"The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes","volume":"16","author":"Incoronato","year":"2004","journal-title":"Cell Signal"},{"issue":"41","key":"10.6061\/clinics\/2012(Sup01)14_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1074\/jbc.M110.144923","article-title":"Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase","volume":"285","author":"Perrinjaquet","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/ERC-08-0096","article-title":"Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10","volume":"16","author":"Machens","year":"2009","journal-title":"Endocr Relat Cancer"},{"issue":"20","key":"10.6061\/clinics\/2012(Sup01)14_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/MCB.21.20.6719-6730.2001","article-title":"The sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis","volume":"21","author":"Mograbi","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.6061\/clinics\/2012(Sup01)14_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nsmb.1808","article-title":"Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations","volume":"17","author":"Kjaer","year":"2010","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J Med Genet"},{"issue":"4","key":"10.6061\/clinics\/2012(Sup01)14_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1210\/me.2003-0173","article-title":"Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease","volume":"18","author":"Arighi","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/hmg\/3.12.2163","article-title":"Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene","volume":"3","author":"Mulligan","year":"1994","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpedsurg.2009.10.080","article-title":"Familial associations in medullary thyroid carcinoma with Hirschsprung disease: the role of the RET-C620 \u201cJanus\u201d genetic variation","volume":"45","author":"Moore","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib48","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bpj.2008.10.041","article-title":"Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability","volume":"96","author":"Dixit","year":"2009","journal-title":"Biophys J"},{"issue":"22","key":"10.6061\/clinics\/2012(Sup01)14_bib49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/0008-5472.CAN-06-3329","article-title":"Molecular Mechanisms of RET Receptor-Mediated Oncogenesis in Multiple Endocrine Neoplasia 2B","volume":"66","author":"Gujral","year":"2006","journal-title":"Cancer Res"},{"issue":"44","key":"10.6061\/clinics\/2012(Sup01)14_bib50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1074\/jbc.M605604200","article-title":"Structure and chemical inhibition of the RET tyrosine kinase domain","volume":"281","author":"Knowles","year":"2006","journal-title":"J Biol Chem"},{"issue":"20","key":"10.6061\/clinics\/2012(Sup01)14_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/0008-5472.CAN-06-0884","article-title":"RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B","volume":"66","author":"Cranston","year":"2006","journal-title":"Cancer Res"},{"issue":"11","key":"10.6061\/clinics\/2012(Sup01)14_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1158\/0008-5472.CAN-03-3801","article-title":"Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors","volume":"64","author":"Jain","year":"2004","journal-title":"Cancer Res"},{"issue":"5","key":"10.6061\/clinics\/2012(Sup01)14_bib53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/gcc.20653","article-title":"RET-mediated gene expression pattern is affected by isoform but not oncogenic mutation","volume":"48","author":"Hickey","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"10.6061\/clinics\/2012(Sup01)14_bib54","first-page":"31","article-title":"Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B","volume":"61","author":"Salvatore","year":"2001","journal-title":"Cancer Res"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/373536a0","article-title":"Catalytic specificity of protein-tyrosine kinases is critical for selective signalling","volume":"373","author":"Songyang","year":"1995","journal-title":"Nature"},{"issue":"8","key":"10.6061\/clinics\/2012(Sup01)14_bib56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/07853890701646256","article-title":"Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases","volume":"39","author":"Runeberg-Roos","year":"2007","journal-title":"Ann Med"},{"issue":"22","key":"10.6061\/clinics\/2012(Sup01)14_bib57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.onc.1209349","article-title":"RET ligand-induced internalization and its consequences for downstream signaling","volume":"25","author":"Richardson","year":"2006","journal-title":"Oncogene"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/jcem.82.11.4508","article-title":"Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation","volume":"82","author":"Gimm","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/sj.onc.1201481","article-title":"Germline mutation of RET codon 883 in two cases of de novo MEN 2B","volume":"15","author":"Smith","year":"1997","journal-title":"Oncogene"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1089\/thy.2010.0328","article-title":"Multiple Endocrine Neoplasia Type 2B with a RET Proto-Oncogene A883F Mutation Displays a More Indolent Form of Medullary Thyroid Carcinoma Compared with a RET M918T Mutation","volume":"21","author":"Jasim","year":"2011","journal-title":"Thyroid"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1349-7006.1999.tb00658.x","article-title":"Two germline missense mutations at codons 804 and 806 of the RET proto- oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation","volume":"90","author":"Miyauchi","year":"1999","journal-title":"Jpn J Cancer Res"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1210\/jcem.87.1.8136","article-title":"Atypical MEN type 2B associated with two germline RET mutations on the same allele not involving codon 918","volume":"87","author":"Menko","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/bbrc.2000.2227","article-title":"A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations","volume":"268","author":"Iwashita","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1530\/EJE-10-0333","article-title":"Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes","volume":"163","author":"Romei","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"10.6061\/clinics\/2012(Sup01)14_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1210\/jc.2010-0375","article-title":"The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A","volume":"95","author":"Schulte","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.6061\/clinics\/2012(Sup01)14_bib66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1158\/0008-5472.CAN-04-2363","article-title":"RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src\/JAK\/STAT3 pathway, independent of glial cell line-derived neurotrophic factor","volume":"65","author":"Plaza Menacho","year":"2005","journal-title":"Cancer Res"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib67","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-0004.2010.01453.x","article-title":"RET codon 804 mutations in multiple endocrine neoplasia 2: genotype-phenotype correlations and implications in clinical management","volume":"79","author":"Mukherjee","year":"2011","journal-title":"Clin Genet"},{"issue":"36","key":"10.6061\/clinics\/2012(Sup01)14_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.onc.1207810","article-title":"Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors","volume":"23","author":"Carlomagno","year":"2004","journal-title":"Oncogene"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1677\/ERC-08-0213","article-title":"Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474","volume":"16","author":"Carlomagno","year":"2009","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"10.6061\/clinics\/2012(Sup01)14_bib70","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1200\/JCO.2009.23.6604","article-title":"Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer","volume":"28","author":"Wells","year":"2010","journal-title":"J Clin Oncol"},{"issue":"29","key":"10.6061\/clinics\/2012(Sup01)14_bib71","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1200\/JCO.2008.16.3279","article-title":"Phase II trial of sorafenib in advanced thyroid cancer","volume":"26","author":"Gupta-Abramson","year":"2008","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.6061\/clinics\/2012(Sup01)14_bib72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1200\/JCO.2008.18.2717","article-title":"Phase II trial of sorafenib in metastatic thyroid cancer","volume":"27","author":"Kloos","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.6061\/clinics\/2012(Sup01)14_bib73","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1074\/jbc.M312600200","article-title":"Identification of RET autophosphorylation sites by mass spectrometry","volume":"279","author":"Kawamoto","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"10.6061\/clinics\/2012(Sup01)14_bib74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1074\/jbc.M608952200","article-title":"Ras\/ERK1\/2-mediated STAT3 Serine 727 phosphorylation by familiar medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity and transformation","volume":"282","author":"Plaza-Menacho","year":"2007","journal-title":"J Biol Chem"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12020-009-9242-7","article-title":"RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crest","volume":"36","author":"Vaclavikova","year":"2009","journal-title":"Endocrine"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/jc.2009-1355","article-title":"High penetrance of pheochromocytoma associated with the novel C634Y\/Y791F double germline mutation in the RET protooncogene","volume":"95","author":"Toledo","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib77","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/jc.2009-1728","article-title":"Pathogenicity of DNA variants and double mutations in multiple endocrine neoplasia type 2 and von Hippel-Lindau syndrome","volume":"95","author":"Erlic","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.6061\/clinics\/2012(Sup01)14_bib78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/(SICI)1098-1004(1997)9:3<243::AID-HUMU5>3.0.CO;2-8","article-title":"Frequency of RET mutations in long- and short-segment Hirschsprung disease","volume":"9","author":"Seri","year":"1997","journal-title":"Hum Mutat"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib79","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1136\/jmg.40.2.e10","article-title":"Association of germline mutations and polymorphisms of the RET proto-oncogene with idiopathic congenital central hypoventilation syndrome in 33 patients","volume":"40","author":"Fitze","year":"2003","journal-title":"J Med Genet"},{"issue":"1","key":"10.6061\/clinics\/2012(Sup01)14_bib80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jso.20277","article-title":"The role of glial cell line-derived neurotrophic factor (GDNF) and integrins for invasion and metastasis in human pancreatic cancer cells","volume":"91","author":"Funahashi","year":"2005","journal-title":"J Surg Oncol"},{"issue":"24","key":"10.6061\/clinics\/2012(Sup01)14_bib81","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/0008-5472.CAN-07-2343","article-title":"A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET\/GFR alpha 1 receptor up-regulation in breast cancer","volume":"67","author":"Esseghir","year":"2007","journal-title":"Cancer Res"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib82","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/jnci\/djp456","article-title":"Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves","volume":"102","author":"Gil","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.6061\/clinics\/2012(Sup01)14_bib83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ajhg.2007.10.008","article-title":"Renal aplasia in humans is associated with RET mutations","volume":"82","author":"Skinner","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"10","key":"10.6061\/clinics\/2012(Sup01)14_bib84","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1681\/ASN.2007101098","article-title":"A common RET variant is associated with reduced newborn kidney size and function","volume":"19","author":"Zhang","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"10.6061\/clinics\/2012(Sup01)14_bib85","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/nrneurol.2011.149","article-title":"Parkinson disease: Is GDNF beneficial in Parkinson disease","volume":"7","author":"Hoffer","year":"2011","journal-title":"Nat Rev Neurol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222024000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222024000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/clinics.org.br\/uploads\/artigos\/cln-67-s1\/cln-67-s1-77.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:14:30Z","timestamp":1761722070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222024000"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_abstract&pid=S1807-59322012001300014&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3328826\/?report=classic","label":"PMC"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":85,"alternative-id":["S1807593222024000"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2012(sup01)14","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2012(Sup01)14","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}