{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:55:59Z","timestamp":1774648559050,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,6,30]],"date-time":"2013-06-30T00:00:00Z","timestamp":1372550400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.6061\/clinics\/2013(06)07","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T08:33:12Z","timestamp":1370853192000},"page":"766-771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients"],"prefix":"10.1016","volume":"68","author":[{"given":"Juliana Cruz","family":"da Silva","sequence":"first","affiliation":[]},{"given":"Henrique Ataide","family":"Mariz","sequence":"additional","affiliation":[]},{"given":"Laurindo Ferreira","family":"da Rocha J\u00fanior","sequence":"additional","affiliation":[]},{"given":"Priscilla Stela","family":"Santana de Oliveira","sequence":"additional","affiliation":[]},{"given":"Andrea Tavares","family":"Dantas","sequence":"additional","affiliation":[]},{"given":"Angela Luzia Branco Pinto","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Ivan","family":"da Rocha Pitta","sequence":"additional","affiliation":[]},{"given":"Suely Lins","family":"Galdino","sequence":"additional","affiliation":[]},{"given":"Maira Galdino","family":"da Rocha Pitta","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"2","key":"10.6061\/clinics\/2013(06)07_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12016-010-8243-x","article-title":"Hydroxychloroquine: from malaria to autoimmunity","volume":"42","author":"Ben-Zvi","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"10.6061\/clinics\/2013(06)07_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/BOR.0b013e32834456bf","article-title":"Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action","volume":"23","author":"Katz","year":"2011","journal-title":"Curr Opin Rheumatol"},{"issue":"9","key":"10.6061\/clinics\/2013(06)07_bib3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrrheum.2012.106","article-title":"New insights into mechanisms of therapeutic effects of antimalarial agents in SLE","volume":"8","author":"Wallace","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"10.6061\/clinics\/2013(06)07_bib4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncprheum0292","article-title":"Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling","volume":"2","author":"Kyburz","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"1","key":"10.6061\/clinics\/2013(06)07_bib5","first-page":"175","volume":"79","author":"Ziegler","year":"1982","journal-title":"Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells"},{"issue":"7","key":"10.6061\/clinics\/2013(06)07_bib6","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1073\/pnas.75.7.3327","article-title":"Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents","volume":"75","author":"Ohkuma","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.6061\/clinics\/2013(06)07_bib7","first-page":"1124","article-title":"The influence of antimalarial treatment on IL-1beta, IL-6 and TNF-alpha mRNA expression on UVB-irradiated skin in systemic lupus erythematosus","volume":"159","author":"Wozniacka","year":"2008","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.6061\/clinics\/2013(06)07_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","article-title":"Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies","volume":"181","author":"Maddur","year":"2012","journal-title":"Am J Pathol"},{"issue":"2","key":"10.6061\/clinics\/2013(06)07_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2249.2009.03944.x","article-title":"Interleukin-17 and systemic lupus erythematosus: current concepts","volume":"157","author":"Nalbandian","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"8","key":"10.6061\/clinics\/2013(06)07_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1191\/096120300678828703","article-title":"Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus","volume":"9","author":"Wong","year":"2000","journal-title":"Lupus"},{"issue":"5","key":"10.6061\/clinics\/2013(06)07_bib11","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/art.24499","article-title":"Th17 and natural Treg cell population dynamics in systemic lupus erythematosus","volume":"60","author":"Yang","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.6061\/clinics\/2013(06)07_bib12","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/rheumatology\/kep255","article-title":"The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus","volume":"48","author":"Kwan","year":"2009","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.6061\/clinics\/2013(06)07_bib13","first-page":"543","article-title":"IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients","volume":"116","author":"Dong","year":"2003","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"10.6061\/clinics\/2013(06)07_bib14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E","article-title":"Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium","volume":"42","author":"Chabaud","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.6061\/clinics\/2013(06)07_bib15","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model","volume":"204","author":"Hirota","year":"2007","journal-title":"J Exp Med"},{"issue":"11","key":"10.6061\/clinics\/2013(06)07_bib16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.6061\/clinics\/2013(06)07_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.6061\/clinics\/2013(06)07_bib18","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/ar2964","article-title":"Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus","volume":"12","author":"Shah","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.6061\/clinics\/2013(06)07_bib19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/BOR.0b013e32833c62b0","article-title":"Interleukin-17-producing T cells in lupus","volume":"22","author":"Crispin","year":"2010","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"10.6061\/clinics\/2013(06)07_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0002-9440(10)62961-6","article-title":"Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1","volume":"167","author":"Koenders","year":"2005","journal-title":"Am J Pathol"},{"issue":"7","key":"10.6061\/clinics\/2013(06)07_bib21","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3899\/jrheum.111027","article-title":"Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity","volume":"39","author":"da Rocha","year":"2012","journal-title":"J Rheumatol"},{"issue":"3","key":"10.6061\/clinics\/2013(06)07_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/096120339600500313","article-title":"Controlled trial with chloroquine diphosphate in systemic lupus erythematosus","volume":"5","author":"Meinao","year":"1996","journal-title":"Lupus"},{"issue":"8","key":"10.6061\/clinics\/2013(06)07_bib23","first-page":"1457","article-title":"Comparison of hydroxychloroquine and placebo in the treatment of the arthropathy of mild systemic lupus erythematosus","volume":"21","author":"Williams","year":"1994","journal-title":"J Rheumatol"},{"issue":"6","key":"10.6061\/clinics\/2013(06)07_bib24","first-page":"356","article-title":"Protective effect of hydroxychloroquine in systemic lupus erythematosus","volume":"11","author":"Molad","year":"2002","journal-title":"Prospective long-term study of an Israeli cohort. Lupus"},{"issue":"3","key":"10.6061\/clinics\/2013(06)07_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1056\/NEJM199101173240303","article-title":"A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus","volume":"324","author":"The Canadian Hydroxychloroquine Study Group","year":"1991","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.6061\/clinics\/2013(06)07_bib26","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1177\/0961203396005001051","article-title":"Hydroxychloroquine use in the Baltimore Lupus Cohort: effects on lipids, glucose and thrombosis","author":"Petri","year":"1996","journal-title":"Lupus"},{"issue":"25","key":"10.6061\/clinics\/2013(06)07_bib27","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1056\/NEJMoa035471","article-title":"Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus","volume":"349","author":"Roman","year":"2003","journal-title":"N Engl J Med"},{"issue":"9","key":"10.6061\/clinics\/2013(06)07_bib28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1136\/ard.2006.068676","article-title":"Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L)","volume":"66","author":"Alarcon","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.6061\/clinics\/2013(06)07_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0961203306071872","article-title":"Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus","volume":"15","author":"Ruiz-Irastorza","year":"2006","journal-title":"Lupus"},{"issue":"11","key":"10.6061\/clinics\/2013(06)07_bib30","first-page":"1067","article-title":"Hydroxychloroquine compared with placebo in rheumatoid arthritis","volume":"119","author":"Clark","year":"1993","journal-title":"A randomized controlled trial. Ann Intern Med"},{"issue":"2","key":"10.6061\/clinics\/2013(06)07_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/jama.298.2.187","article-title":"Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis","volume":"298","author":"Wasko","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.6061\/clinics\/2013(06)07_bib32","first-page":"55","article-title":"Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells","volume":"24","author":"van den Borne","year":"1997","journal-title":"J Rheumatol"},{"issue":"1","key":"10.6061\/clinics\/2013(06)07_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.0019-2805.2001.01339.x","article-title":"Chloroquine decreases cell-surface expression of tumour necrosis factor receptors in human histiocytic U-937 cells","volume":"105","author":"Jeong","year":"2002","journal-title":"Immunology"},{"issue":"8","key":"10.6061\/clinics\/2013(06)07_bib34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1084\/jem.20050914","article-title":"Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus","volume":"202","author":"Barrat","year":"2005","journal-title":"J Exp Med"},{"issue":"9","key":"10.6061\/clinics\/2013(06)07_bib35","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncprheum0292","article-title":"Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling","volume":"2","author":"Kyburz","year":"2006","journal-title":"Nat Clin Pract Rheumatol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222016921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222016921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/clinics.org.br\/uploads\/artigos\/cln-68-06\/cln-68-06-766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:05:47Z","timestamp":1761721547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222016921"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_abstract&pid=S1807-59322013000600766&lng=en&nrm=iso","label":"SCIELO"},{"URL":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3674253\/?report=classic","label":"PMC"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1807593222016921"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2013(06)07","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2013(06)07","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}