none 10.6061/clinics/2016(01)07 Elsevier BV Elsevier 78 80367555 45578 2025102811221600000 10.1016 2025-10-29T07:01:39Z 2016-02-05T12:34:48Z 16 Clinics Clinics 18075932 01 2016 71 1 Jose Manuel Ceresetto 01 2016 36 46 S180759322201300X S180759322201300X 10.1016/elsevier_cm_policy elsevier.com sciencedirect.com true Elsevier Venous thromboembolism in Latin America: a review and guide to diagnosis and treatment for primary care Clinics https://doi.org/10.6061/clinics/2016(01)07 article Copyright © 2016 CLINICS. Published by Elsevier Spain https://www.elsevier.com/tdm/userlicense/1.0/ https://www.elsevier.com/legal/tdmrep-license https://creativecommons.org/licenses/by/4.0/ 10.6061/clinics/2016(01)07 https://linkinghub.elsevier.com/retrieve/pii/S180759322201300X https://api.elsevier.com/content/article/PII:S180759322201300X?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S180759322201300X?httpAccept=text/plain https://dul.usage.elsevier.com/doi/ http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-59322016000100036&lng=en&nrm=iso http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732387/?report=classic Circulation White 107 23 Suppl 1 14 2003 The epidemiology of venous thromboembolism Cir Cir Martínez-Zubieta 78 4 333 2010 [Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE II study): results of a Mexican national cross-sectional study] J Bras Pneumol Andrade 35 2 114 2009 10.1590/S1806-37132009000200003 Risk factors and prophylaxis for venous thromboembolism in hospitals in the city of Manaus, Brazil Thromb J Vazquez 11 1 16 2013 10.1186/1477-9560-11-16 Incidence rate of symptomatic venous thromboembolic disease in patients from a medical care program in Buenos Aires, Argentina: a prospective cohort Medicina (B Aires) Mazzei 65 4 289 2005 [Frequency and incidence of venous thromboembolism in a general hospital] Arq Bras Cardiol Volschan 93 2 135 2009 Predictors of hospital mortality in hemodynamically stable patients with pulmonary embolism Clinics Carvalho Bricola 68 5 679 2013 10.6061/clinics/2013(05)16 Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study Intern Med J Majluf-Cruz 42 12 1335 2012 10.1111/j.1445-5994.2011.02646.x Awareness regarding venous thromboembolism among internal medicine practitioners in Mexico: a national cross-sectional study Biomedica Dennis 31 2 200 2011 10.7705/biomedica.v31i2.304 [Venous thromboembolism prophylaxis in Colombian surgical and medical patients: results for Colombia of the ENDORSE study] Thromb J Languasco 9 18 2011 10.1186/1477-9560-9-18 Adherence to local guidelines for venous thromboprophylaxis: a cross-sectional study of medical inpatients in Argentina Semin Thromb Hemost Caiafa 28 Suppl 3 47 2002 10.1055/s-2002-34076 Managing venous thromboembolism in Latin American patients: emerging results from the Brazilian Registry J Thromb Haemost Deheinzelin 4 6 1266 2006 10.1111/j.1538-7836.2006.01981.x Incorrect use of thromboprophylaxis for venous thromboembolism in medical and surgical patients: results of a multicentric, observational and cross-sectional study in Brazil J Bras Pneumol Fuzinatto 37 2 160 2011 10.1590/S1806-37132011000200005 Venous thromboembolism prophylaxis in a general hospital Cir Cir Martinez-Zubieta 78 4 333 2010 [Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE II study): results of a Mexican national cross-sectional study] Medicina (B Aires) Melero 72 5 361 2012 [Venous thromboembolism prevention in non-surgical adult patients admitted in a general hospital] Arq Gastroenterol Diogo-Filho 46 1 9 2009 10.1590/S0004-28032009000100007 [Study of epidemiological surveillance of venous thromboembolism prophylaxis in surgical specialties of a school tertiary referral hospital] BMC Public Health Bennett 11 415 2011 10.1186/1471-2458-11-415 Characteristics of patients with venous thromboembolism and atrial fibrillation in Venezuela Blood Coagul Fibrinolysis de Bastos 24 7 691 2013 10.1097/MBC.0b013e328360a52c Assessment of characteristics associated with pharmacologic thromboprophylaxis use in hospitalized patients: a cohort study of 10,016 patients Thromb J Vazquez 12 15 2014 10.1186/1477-9560-12-15 Risk of venous thromboembolic disease and adequacy of prophylaxis in hospitalized patients in Argentina: a multicentric cross-sectional study Lancet Cohen 371 9610 387 2008 10.1016/S0140-6736(08)60202-0 Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study J Thromb Haemost ISTH Steering Committee for World Thrombosis Day 12 10 1580 2014 10.1111/jth.12698 Thrombosis: a major contributor to the global disease burden International Society for Thrombosis and Haemostasis Rev Med Inst Mex Seguro Soc Martinez-Murillo 49 4 437 2011 [Clinical guideline for diagnosis and treatment of the thromboembolic venous disease] J Bras Pneumol Terra-Filho 36 Suppl 1 S1 2010 10.1590/S1806-37132010001300001 [Recommendations for the management of pulmonary thromboembolism, 2010] Revista Argentina de Cardiología Ubaldini 77 5 412 2009 Consenso de enfermedad tromboembólica. Consenso Argentino de la Sociedad Argentina de Cardiología J Bras Pneumol Fuzinatto 39 2 138 2013 10.1590/S1806-37132013000200004 A clinical decision support system for venous thromboembolism prophylaxis at a general hospital in a middle-income country Rev Assoc Med Bras Rocha 56 2 197 2010 10.1590/S0104-42302010000200019 [Impact of a program for venous thromboembolism prophylaxis in hospitalized patients in four hospitals in Salvador] J Thromb Haemost Goldhaber 5 8 1607 2007 10.1111/j.1538-7836.2007.02651.x Preventing pulmonary embolism and deep vein thrombosis: a ‘call to action' for vascular medicine specialists Blood Khorana 111 1 4902 2008 10.1182/blood-2007-10-116327 Development and validation of a predictive model for chemotherapy-associated thrombosis Am J Surg Caprini 199 1 Suppl S3 2010 10.1016/j.amjsurg.2009.10.006 Risk assessment as a guide for the prevention of the many faces of venous thromboembolism Chest Kearon 141 2 Suppl e419S 2012 10.1378/chest.11-2301 Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines JAMA Intern Med Lamontagne 174 5 689 2014 10.1001/jamainternmed.2014.169 Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study Blood Coagul Fibrinolysis Mello 21 7 660 2010 10.1097/MBC.0b013e32833ceaef Long-term prospective study of recurrent venous thromboembolism in a Hispanic population Blood Coagul Fibrinolysis Ribeiro 24 5 562 2013 10.1097/MBC.0b013e32835fad32 Risk of recurrent venous thrombosis related to past provoking risk situations: follow-up of a cohort study Chest Bates 141 2 Suppl e351S 2012 10.1378/chest.11-2299 Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest Munoz 133 1 143 2008 10.1378/chest.07-1432 Clinical outcome of patients with upper-extremity deep vein thrombosis: results from the RIETE Registry Am J Surg Hingorani 174 2 214 1997 10.1016/S0002-9610(97)00088-3 Upper extremity versus lower extremity deep venous thrombosis J Vasc Surg Hingorani 26 5 853 1997 10.1016/S0741-5214(97)70100-9 Upper extremity deep venous thrombosis and its impact on morbidity and mortality rates in a hospital-based population Vasc Endovascular Surg Hingorani 40 2 131 2006 10.1177/153857440604000207 Prospective evaluation of combined upper and lower extremity DVT Thromb Haemost Savage 82 3 1008 1999 10.1055/s-0037-1614319 Outpatient use of low molecular weight heparin (dalteparin) for the treatment of deep vein thrombosis of the upper extremity Thromb Haemost Grant 108 6 1097 2012 10.1160/TH12-05-0352 Diagnosis and management of upper extremity deep-vein thrombosis in adults Circulation Jaff 123 16 1788 2011 10.1161/CIR.0b013e318214914f Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association Circulation Piazza 122 11 1124 2010 10.1161/CIRCULATIONAHA.110.961136 Management of submassive pulmonary embolism Mt Sinai J Med Langan 7 3 528 2006 New diagnostic and treatment modalities for pulmonary embolism: one path through the confusion Lancet Goldhaber 353 9162 1386 1999 10.1016/S0140-6736(98)07534-5 Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) Circulation Kucher 113 4 577 2006 10.1161/CIRCULATIONAHA.105.592592 Massive pulmonary embolism Thromb Haemost Cohen 98 4 756 2007 Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality CMAJ Scarvelis 175 9 1087 2006 10.1503/cmaj.060366 Diagnosis and treatment of deep-vein thrombosis JAMA van Belle 295 2 172 2006 10.1001/jama.295.2.172 Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography Ann Intern Med Le 144 3 165 2006 10.7326/0003-4819-144-3-200602070-00004 Prediction of pulmonary embolism in the emergency department: the revised Geneva score Arch Intern Med Jimenez 170 15 1383 2010 10.1001/archinternmed.2010.199 Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism Am J Respir Crit Care Med Aujesky 172 8 1041 2005 10.1164/rccm.200506-862OC Derivation and validation of a prognostic model for pulmonary embolism Eur Heart J Konstantinides 35 43 3033 2014 10.1093/eurheartj/ehu283 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Endorsed by the European Respiratory Society (ERS) J Vasc Surg Lozano 59 5 1362 2014 10.1016/j.jvs.2013.11.091 Home versus in-hospital treatment of outpatients with acute deep venous thrombosis of the lower limbs Acta Bioquím. Clín. Latinoam Korin 1 PO22 42 2014 Tratamiento ambulatorio de la trombosis venosa N Engl J Med Hylek 335 8 540 1996 10.1056/NEJM199608223350802 An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation Circulation Healey 124 2011 10.1161/circ.124.suppl_21.A9174 Abstract 9174: Global Variation in the Etiology and Management of Atrial Fibrillation: Results from a Global Atrial Fibrillation Registry N Engl J Med Connolly 361 12 1139 2009 10.1056/NEJMoa0905561 Dabigatran versus warfarin in patients with atrial fibrillation Am J Med Matchar 113 1 42 2002 10.1016/S0002-9343(02)01131-2 Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial Latinoam Ceresetto 19 2014 Evaluación del Tiempo en Rango Terapéutico con antagonistas de la vitamina K en pacientes con Fibrilación Auricular en Argentina. Estudio multicéntrico TERRA. Acta bioquím. Clín Blood Schulman 119 13 3016 2012 10.1182/blood-2011-10-378950 How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch J Thromb Haemost van der Hulle 12 3 320 2014 10.1111/jth.12485 Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis Blood Yeh 124 7 1020 2014 10.1182/blood-2014-03-563056 Evolving use of new oral anticoagulants for treatment of venous thromboembolism Circulation Schulman 129 7 764 2014 10.1161/CIRCULATIONAHA.113.004450 Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis N Engl J Med Schulman 368 8 709 2013 10.1056/NEJMoa1113697 Extended use of dabigatran, warfarin, or placebo in venous thromboembolism N Engl J Med Schulman 361 24 2342 2009 10.1056/NEJMoa0906598 Dabigatran versus warfarin in the treatment of acute venous thromboembolism N Engl J Med Bauersachs 363 26 2499 2010 10.1056/NEJMoa1007903 Oral rivaroxaban for symptomatic venous thromboembolism N Engl J Med Buller 366 14 1287 2012 10.1056/NEJMoa1113572 Oral rivaroxaban for the treatment of symptomatic pulmonary embolism N Engl J Med Agnelli 369 9 799 2013 10.1056/NEJMoa1302507 Oral apixaban for the treatment of acute venous thromboembolism N Engl J Med Agnelli 368 8 699 2013 10.1056/NEJMoa1207541 Apixaban for extended treatment of venous thromboembolism N Engl J Med The Hokusai-VTE Investigators 369 15 1406 2013 10.1056/NEJMoa1306638 Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism Daiichi Sankyo PAN AMERICAN HEALTH ORGANIZATION Thromb Haemost Deitelzweig 100 5 810 2008 10.1160/TH08-04-0248 Comparison of the two-year outcomes and costs of prophylaxis in medical patients at risk of venous thromboembolism J Hosp Med Leykum 1 3 168 2006 10.1002/jhm.97 Cost utility of substituting enoxaparin for unfractionated heparin for prophylaxis of venous thrombosis in the hospitalized medical patient Arch Intern Med Wells 158 16 1809 1998 10.1001/archinte.158.16.1809 Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injection Vasc Surg Schwarz 34 6 1065 2001 10.1067/mva.2001.118821 Eligibility for home treatment of deep vein thrombosis: a prospective study in 202 consecutive patients PLoS One Escolar 8 11 2013 10.1371/journal.pone.0078696 Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: significance of studies in vitro with circulating human blood Circ J Escolar 79 2 331 2015 10.1253/circj.CJ-14-0909 Reversal of rivaroxaban-induced alterations on hemostasis by different coagulation factor concentrates – in vitro studies with steady and circulating human blood Thromb Res Lindahl 135 3 544 2015 10.1016/j.thromres.2014.12.019 More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin complex concentrate or recombinant factor VIIa than by four-factor prothrombin complex concentrate Circulation Zahir 131 1 82 2015 10.1161/CIRCULATIONAHA.114.013445 Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate Boehringer Ingelheim Pharmaceuticals, Inc. N Engl J Med Siegal 373 25 2413 2015 10.1056/NEJMoa1510991 Andexanet alfa for the reversal of factor Xa inhibitor activity N Engl J Med Ansell 371 22 2141 2014 10.1056/NEJMc1411800 Use of PER977 to reverse the anticoagulant effect of edoxaban J Thromb Thrombolysis Samoš 39 1 95 2015 10.1007/s11239-014-1125-y Monitoring of dabigatran therapy using Hemoclot® Thrombin Inhibitor assay in patients with atrial fibrillation J Thromb Haemost Hillarp 12 9 1545 2014 10.1111/jth.12649 Effects of the oral, direct factor Xa inhibitor apixaban on routine coagulation assays and anti-FXa assays Thromb Haemost Mani 108 1 191 2012 Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin Int J Med Sci Tsai 10 10 1352 2013 10.7150/ijms.6714 Clustering patterns of comorbidities associated with in-hospital death in hospitalizations of US adults with venous thromboembolism J Gen Intern Med Leiss 30 1 17 2015 10.1007/s11606-014-2993-8 Polypharmacy is associated with an increased risk of bleeding in elderly patients with venous thromboembolism Respiration Ng 85 5 408 2013 10.1159/000342024 Prognostic impact of the Charlson comorbidity index on mortality following acute pulmonary embolism PLoS One Tsai 8 2013 10.1371/journal.pone.0070061 Predictive accuracy of 29-comorbidity index for in-hospital deaths in US adult hospitalizations with a diagnosis of venous thromboembolism N Engl J Med Wells 349 13 1227 2003 10.1056/NEJMoa023153 Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis Thromb Haemost Wells 83 3 416 2000 10.1055/s-0037-1613830 Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer