{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:16:58Z","timestamp":1773735418367,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T00:00:00Z","timestamp":1493510400000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2017]]},"DOI":"10.6061\/clinics\/2017(04)08","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T08:11:00Z","timestamp":1494490260000},"page":"238-243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Human islet xenotransplantation in rodents: A literature review of experimental model trends"],"prefix":"10.1016","volume":"72","author":[{"given":"Leandro Ryuchi","family":"Iuamoto","sequence":"first","affiliation":[]},{"given":"Andr\u00e9 Silva","family":"Franco","sequence":"additional","affiliation":[]},{"given":"F\u00e1bio Yuji","family":"Suguita","sequence":"additional","affiliation":[]},{"given":"Felipe Futema","family":"Essu","sequence":"additional","affiliation":[]},{"given":"Lucas Torres","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Juliana Mika","family":"Kato","sequence":"additional","affiliation":[]},{"given":"Matheus Belloni","family":"Torsani","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Meyer","sequence":"additional","affiliation":[]},{"given":"Wellington","family":"Andraus","sequence":"additional","affiliation":[]},{"given":"Eleazar","family":"Chaib","sequence":"additional","affiliation":[]},{"given":"Luiz Augusto Carneiro","family":"D'Albuquerque","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/CS20050342","article-title":"Current status of pancreatic islet transplantation","volume":"110","author":"Merani","year":"2006","journal-title":"Clin Sci"},{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-3083.2009.02356.x","article-title":"Alloreactivity but failure to reject human islet transplants by humanized Balb\/c\/Rag2gc mice","volume":"71","author":"Jacobson","year":"2010","journal-title":"Scand J Immunol"},{"issue":"2-3","key":"10.6061\/clinics\/2017(04)08_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3727\/096368911X605439","article-title":"Fresh islets are more effective for islet transplantation than cultured islets","volume":"21","author":"Noguchi","year":"2012","journal-title":"Cell Transplant"},{"issue":"8","key":"10.6061\/clinics\/2017(04)08_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073526","article-title":"Cooperation by fibroblasts and bone marrow-mesenchymal stem cells to improve pancreatic rat-to-mouse islet xenotransplantation","volume":"8","author":"Perez-Basterrechea","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.6061\/clinics\/2017(04)08_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"issue":"37","key":"10.6061\/clinics\/2017(04)08_bib7","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.3748\/wjg.v20.i37.13512","article-title":"Review of experimental attempts of islet allotransplantation in rodents: parameters involved and viability of the procedure","volume":"20","author":"Iuamoto","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.6061\/clinics\/2017(04)08_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm0397-282","article-title":"Infection of human cells by an endogenous retrovirus of pigs","volume":"3","author":"Patience","year":"1997","journal-title":"Nat Med"},{"issue":"6800","key":"10.6061\/clinics\/2017(04)08_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/35024089","article-title":"Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice","volume":"407","author":"van der Laan","year":"2000","journal-title":"Nature"},{"issue":"1","key":"10.6061\/clinics\/2017(04)08_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.metabol.2012.07.010","article-title":"Evaluating insulin secretagogues in a humanized mouse model with functional human islets","volume":"62","author":"Luo","year":"2013","journal-title":"Metabolism"},{"issue":"10","key":"10.6061\/clinics\/2017(04)08_bib11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jemt.20721","article-title":"Effect of black tea on histological and immunohistochemical changes in pancreatic tissues of normal and streptozotocin-induced diabetic mice (Mus musculus)","volume":"72","author":"Manikandan","year":"2009","journal-title":"Microsc Res Tech"},{"issue":"5","key":"10.6061\/clinics\/2017(04)08_bib12","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1021\/nn400630x","article-title":"Injectable nano-network for glucose-mediated insulin delivery","volume":"7","author":"Gu","year":"2013","journal-title":"ACS Nano"},{"issue":"25","key":"10.6061\/clinics\/2017(04)08_bib13","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMoa1111732","article-title":"Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes","volume":"365","author":"DCCT\/EDIC Research Group","year":"2011","journal-title":"N Engl J Med"},{"issue":"8","key":"10.6061\/clinics\/2017(04)08_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/TP.0b013e31829fa271","article-title":"Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model","volume":"96","author":"Wu","year":"2013","journal-title":"Transplantation"},{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0004-27302008000200024","article-title":"[Pancreas and islet transplantation in patients with diabetes mellitus]","volume":"52","author":"S\u00e1","year":"2008","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"7","key":"10.6061\/clinics\/2017(04)08_bib16","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.2337\/diabetes.54.7.2060","article-title":"Five-year follow-up after clinical islet transplantation","volume":"54","author":"Ryan","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"10.6061\/clinics\/2017(04)08_bib17","first-page":"190","article-title":"Parameters involved and viability of immunosuppression on islet allotransplantation procedure in rodents","volume":"1","author":"Iuamoto","year":"2014","journal-title":"MedicalExpress (S\u00e3o Paulo, online)"},{"issue":"1","key":"10.6061\/clinics\/2017(04)08_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0004-27302009000100004","article-title":"[Islet transplantation as a clinical tool: present state and future perspectives]","volume":"53","author":"Eliaschewitz","year":"2009","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"9","key":"10.6061\/clinics\/2017(04)08_bib19","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.2337\/db10-0323","article-title":"Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice","volume":"59","author":"Brehm","year":"2010","journal-title":"Diabetes"},{"issue":"21","key":"10.6061\/clinics\/2017(04)08_bib20","first-page":"3106","article-title":"Inhibition of rejection in murine islet xenografts by CTLA4Ig and CD40LIg gene transfer","volume":"123","author":"Zhang","year":"2010","journal-title":"Chin Med J (Engl)"},{"issue":"7","key":"10.6061\/clinics\/2017(04)08_bib21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2337\/db09-0588","article-title":"Redox modulation protects islets from transplant-related injury","volume":"59","author":"Sklavos","year":"2010","journal-title":"Diabetes"},{"issue":"11","key":"10.6061\/clinics\/2017(04)08_bib22","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1097\/TP.0b013e3181d98af1","article-title":"Prolactin supplementation to culture medium improves beta-cell survival","volume":"89","author":"Yamamoto","year":"2010","journal-title":"Transplantation"},{"issue":"10","key":"10.6061\/clinics\/2017(04)08_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003559","article-title":"Beta cells within single human islets originate from multiple progenitors","volume":"3","author":"Scharfmann","year":"2008","journal-title":"PLoS One"},{"issue":"8","key":"10.6061\/clinics\/2017(04)08_bib24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00125-008-1057-1","article-title":"A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function","volume":"51","author":"Pearson","year":"2008","journal-title":"Diabetologia"},{"issue":"7","key":"10.6061\/clinics\/2017(04)08_bib25","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.2337\/db08-0054","article-title":"Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD\/SCID mice","volume":"57","author":"Vlad","year":"2008","journal-title":"Diabetes"},{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00125-007-0889-4","article-title":"Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation","volume":"51","author":"Fornoni","year":"2008","journal-title":"Diabetologia"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/xen.12009","article-title":"Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+","volume":"19","author":"Qi","year":"2012","journal-title":"Xenotransplantation"},{"issue":"5","key":"10.6061\/clinics\/2017(04)08_bib28","doi-asserted-by":"crossref","first-page":"E866","DOI":"10.1210\/jc.2013-2221","article-title":"Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus","volume":"99","author":"Oh","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10495-013-0834-6","article-title":"Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets","volume":"18","author":"Brandhorst","year":"2013","journal-title":"Apoptosis"},{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00125-012-2764-1","article-title":"Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes","volume":"56","author":"Liu","year":"2013","journal-title":"Diabetologia"},{"issue":"12","key":"10.6061\/clinics\/2017(04)08_bib31","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.3727\/096368912X653138","article-title":"Supplements in human islet culture: human serum albumin is inferior to fetal bovine serum","volume":"21","author":"Avgoustiniatos","year":"2012","journal-title":"Cell Transplant"},{"issue":"1","key":"10.6061\/clinics\/2017(04)08_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pan.2011.11.002","article-title":"A novel tissue for islet transplantation in diabetics","volume":"12","author":"Pour","year":"2012","journal-title":"Pancreatology"},{"issue":"1","key":"10.6061\/clinics\/2017(04)08_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.surg.2011.02.023","article-title":"The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice","volume":"150","author":"McCall","year":"2011","journal-title":"Surgery"},{"issue":"7","key":"10.6061\/clinics\/2017(04)08_bib34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/TP.0b013e31822bc95a","article-title":"Glial cell line-derived neurotrophic factor enhances human islet posttransplantation survival","volume":"92","author":"Mwangi","year":"2011","journal-title":"Transplantation"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib35","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.transproceed.2010.05.080","article-title":"Imaging of human islet vascularization using a dorsal window model","volume":"42","author":"Sabek","year":"2010","journal-title":"Transplant Proc"},{"issue":"2","key":"10.6061\/clinics\/2017(04)08_bib36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.surg.2010.05.013","article-title":"Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles","volume":"148","author":"Rink","year":"2010","journal-title":"Surgery"},{"issue":"8","key":"10.6061\/clinics\/2017(04)08_bib37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1007\/s00125-010-1721-0","article-title":"Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity","volume":"53","author":"Jacobs-Tulleneers-Thevissen","year":"2010","journal-title":"Diabetologia"},{"issue":"3","key":"10.6061\/clinics\/2017(04)08_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1432-2277.2009.00984.x","article-title":"Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture","volume":"23","author":"Toso","year":"2010","journal-title":"Transpl Int"},{"issue":"3","key":"10.6061\/clinics\/2017(04)08_bib39","first-page":"242","article-title":"Growth hormone increases beta-cell proliferation in transplanted human and fetal rat islets","volume":"10","author":"H\u00f6glund","year":"2009","journal-title":"JOP"},{"issue":"7","key":"10.6061\/clinics\/2017(04)08_bib40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/TP.0b013e31819c86ea","article-title":"Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies","volume":"87","author":"Lee","year":"2009","journal-title":"Transplantation"},{"issue":"1-2","key":"10.6061\/clinics\/2017(04)08_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3727\/000000008783907125","article-title":"Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function","volume":"17","author":"Navarro-Alvarez","year":"2008","journal-title":"Cell Transplant"},{"issue":"3","key":"10.6061\/clinics\/2017(04)08_bib42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1600-6143.2006.01655.x","article-title":"Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice","volume":"7","author":"Papas","year":"2007","journal-title":"Am J Transplant"},{"issue":"1","key":"10.6061\/clinics\/2017(04)08_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/nbm.1088","article-title":"Magnetic resonance imaging of gadolinium-labeled pancreatic islets for experimental transplantation","volume":"20","author":"Biancone","year":"2007","journal-title":"NMR Biomed"},{"issue":"1-2","key":"10.6061\/clinics\/2017(04)08_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mce.2006.10.007","article-title":"Maturation of in vitro-generated human islets after transplantation in nude mice","volume":"264","author":"Gao","year":"2007","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"10.6061\/clinics\/2017(04)08_bib45","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1111\/j.1600-6143.2006.01534.x","article-title":"Antiangiogenic and immunomodulatory effects of rapamycin on islet endothelium: relevance for islet transplantation","volume":"6","author":"Cantaluppi","year":"2006","journal-title":"Am J Transplant"},{"issue":"10","key":"10.6061\/clinics\/2017(04)08_bib46","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1016\/j.transproceed.2006.10.117","article-title":"Examination of gene expression profile of functional human pancreatic islets after 2-week culture","volume":"38","author":"Sabek","year":"2006","journal-title":"Transplant Proc"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib47","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ymthe.2006.08.007","article-title":"Long-term monitoring of transplanted islets using positron emission tomography","volume":"14","author":"Lu","year":"2006","journal-title":"Mol Ther"},{"issue":"8-9","key":"10.6061\/clinics\/2017(04)08_bib48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3727\/000000006783981440","article-title":"The use of the BD oxygen biosensor system to assess isolated human islets of langerhans: oxygen consumption as a potential measure of islet potency","volume":"15","author":"Fraker","year":"2006","journal-title":"Cell Transplant"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib49","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","article-title":"Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets","volume":"49","author":"Paulsson","year":"2006","journal-title":"Diabetologia"},{"issue":"6","key":"10.6061\/clinics\/2017(04)08_bib50","doi-asserted-by":"crossref","first-page":"E1168","DOI":"10.1152\/ajpendo.00436.2005","article-title":"Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo","volume":"291","author":"P\u00e4th","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222009863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222009863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:56:09Z","timestamp":1761720969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222009863"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322017000400238&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5401612\/?report=classic","label":"PMC"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"alternative-id":["S1807593222009863"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2017(04)08","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human islet xenotransplantation in rodents: A literature review of experimental model trends","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2017(04)08","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}]}}