{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:20:16Z","timestamp":1780518016540,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":364,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2018]]},"DOI":"10.6061\/clinics\/2018\/e549s","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T09:51:58Z","timestamp":1539683518000},"page":"e549s","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"S1","title":["Innate immunity and HPV: friends or foes"],"prefix":"10.1016","volume":"73","author":[{"given":"Rafaella Almeida Lima","family":"Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Galliote","family":"Morale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela \u00c1vila Fernandes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Lina","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Termini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.virol.2008.11.046","article-title":"Papillomaviruses in the causation of human cancers - a brief historical account","volume":"384","author":"zur Hausen","year":"2009","journal-title":"Virology"},{"issue":"Pt 6","key":"10.6061\/clinics\/2018\/e549s_bib2","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1042\/BST0351456","article-title":"HPV: from infection to cancer","volume":"35","author":"Stanley","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.6061\/clinics\/2018\/e549s_bib3","series-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]","author":"Ferlay","year":"2013"},{"issue":"12","key":"10.6061\/clinics\/2018\/e549s_bib4","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/ijc.23446","article-title":"Risk factors for invasive squamous cell carcinoma of the vulva and vagina\u2013population-based case-control study in Denmark","volume":"122","author":"Madsen","year":"2008","journal-title":"Int J Cancer"},{"issue":"9188","key":"10.6061\/clinics\/2018\/e549s_bib5","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0140-6736(99)92824-6","article-title":"Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas","volume":"354","author":"Frisch","year":"1999","journal-title":"Lancet"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib6","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/ijc.21961","article-title":"Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival","volume":"119","author":"Lont","year":"2006","journal-title":"Int J Cancer"},{"issue":"19","key":"10.6061\/clinics\/2018\/e549s_bib7","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1056\/NEJMoa065497","article-title":"Case-control study of human papillomavirus and oropharyngeal cancer","volume":"356","author":"D\u2019Souza","year":"2007","journal-title":"N Engl J Med"},{"issue":"8","key":"10.6061\/clinics\/2018\/e549s_bib8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ncponc0984","article-title":"Human papillomavirus in cervical and head-and-neck cancer","volume":"5","author":"Psyrri","year":"2008","journal-title":"Nat Clin Pract Oncol"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1086\/317638","article-title":"A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types","volume":"183","author":"Liaw","year":"2001","journal-title":"J Infect Dis"},{"issue":"9","key":"10.6061\/clinics\/2018\/e549s_bib11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.15698\/mic2016.09.530","article-title":"HPV disease transmission protection and control","volume":"3","author":"Christensen","year":"2016","journal-title":"Microb Cell"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib12","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ijc.25400","article-title":"Association between toll-like receptor expression and human papillomavirus type 16 persistence","volume":"128","author":"Daud","year":"2011","journal-title":"Int J Cancer"},{"issue":"10","key":"10.6061\/clinics\/2018\/e549s_bib13","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1002\/ijc.29283","article-title":"Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response","volume":"136","author":"Scott","year":"2015","journal-title":"Int J Cancer"},{"issue":"6","key":"10.6061\/clinics\/2018\/e549s_bib14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"Thompson","year":"2011","journal-title":"Viruses"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib16","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.178.5.3186","article-title":"TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16","volume":"178","author":"Hasan","year":"2007","journal-title":"J Immunol"},{"key":"10.6061\/clinics\/2018\/e549s_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7537","article-title":"The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NF\u03baB activation","volume":"6","author":"Tummers","year":"2015","journal-title":"Nat Commun"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003384","article-title":"Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte\u2019s innate immune response","volume":"9","author":"Karim","year":"2013","journal-title":"PLoS Pathog"},{"issue":"Pt 8","key":"10.6061\/clinics\/2018\/e549s_bib19","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1099\/vir.0.052811-0","article-title":"Polymorphism in the promoter region of the Toll-like receptor 9 gene and cervical human papillomavirus infection","volume":"94","author":"Oliveira","year":"2013","journal-title":"J Gen Virol"},{"issue":"9","key":"10.6061\/clinics\/2018\/e549s_bib20","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/jmv.24514","article-title":"Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development","volume":"88","author":"Pontillo","year":"2016","journal-title":"J Med Virol"},{"issue":"15","key":"10.6061\/clinics\/2018\/e549s_bib21","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1128\/JVI.00013-15","article-title":"The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters","volume":"89","author":"Lo Cigno","year":"2015","journal-title":"J Virol"},{"issue":"8","key":"10.6061\/clinics\/2018\/e549s_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/v9080233","article-title":"Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression","volume":"9","author":"Warren","year":"2017","journal-title":"Viruses"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/156800907780006869","article-title":"Mechanisms used by human papillomaviruses to escape the host immune response","volume":"7","author":"Kanodia","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017848","article-title":"Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes","volume":"6","author":"Karim","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.6061\/clinics\/2018\/e549s_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003536","article-title":"Post-translational control of IL-1\u03b2 via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53","volume":"9","author":"Niebler","year":"2013","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091473","article-title":"E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-\u03ba transcription in keratinocytes","volume":"9","author":"Sunthamala","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib27","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0952-7915(02)00354-0","article-title":"Links between innate and adaptive immunity via type I interferon","volume":"14","author":"Le Bon","year":"2002","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3835(01)00871-0","article-title":"Abrogation of IRF-1 response by high-risk HPV E7 protein in vivo","volume":"179","author":"Um","year":"2002","journal-title":"Cancer Lett"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1399-0039.1998.tb03046.x","article-title":"Differential regulation of HLA-DQ expression by keratinocytes and Langerhans cells in normal and premalignant cervical epithelium","volume":"52","author":"Mota","year":"1998","journal-title":"Tissue Antigens"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ygyno.2006.11.023","article-title":"Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression\u2013clinicopathological correlation","volume":"105","author":"Hammes","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"13","key":"10.6061\/clinics\/2018\/e549s_bib31","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1158\/1078-0432.CCR-09-0489","article-title":"HPV16 tumor associated macrophages suppress antitumor T cell responses","volume":"15","author":"Lepique","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.6061\/clinics\/2018\/e549s_bib32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1471-2407-9-186","article-title":"Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions","volume":"9","author":"Garcia-Iglesias","year":"2009","journal-title":"BMC Cancer"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/imm.12101","article-title":"Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia","volume":"139","author":"Yang","year":"2013","journal-title":"Immunology"},{"issue":"6","key":"10.6061\/clinics\/2018\/e549s_bib34","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1158\/0008-5472.CAN-12-2384","article-title":"Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma","volume":"73","author":"Lyford-Pike","year":"2013","journal-title":"Cancer Res"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/CS20050369","article-title":"Molecular biology of human papillomavirus infection and cervical cancer","volume":"110","author":"Doorbar","year":"2006","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.virol.2008.10.004","article-title":"Interaction of human papillomaviruses with the host immune system: a well evolved relationship","volume":"384","author":"Frazer","year":"2009","journal-title":"Virology"},{"issue":"13","key":"10.6061\/clinics\/2018\/e549s_bib38","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1101\/gad.12.13.2061","article-title":"Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity","volume":"12","author":"Ronco","year":"1998","journal-title":"Genes Dev"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib39","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.4081\/oncol.2012.e17","article-title":"Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection","volume":"6","author":"Senba","year":"2012","journal-title":"Oncol Rev"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygyno.2007.08.095","article-title":"Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis","volume":"108","author":"Mazibrada","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.6061\/clinics\/2018\/e549s_bib41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib42","first-page":"376","article-title":"Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer","volume":"4","author":"Quatromoni","year":"2012","journal-title":"Am J Transl Res"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imm.12023","article-title":"Anti-tumour strategies aiming to target tumour-associated macrophages","volume":"138","author":"Tang","year":"2013","journal-title":"Immunology"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nri3175","article-title":"Coordinated regulation of myeloid cells by tumours","volume":"12","author":"Gabrilovich","year":"2012","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2009.06.018","article-title":"CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages","volume":"16","author":"DeNardo","year":"2009","journal-title":"Cancer Cell"},{"key":"10.6061\/clinics\/2018\/e549s_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1479-5876-10-127","article-title":"T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGF\u03b2) signaling mediate superior tumor regression in an animal model of adoptive cell therapy","volume":"10","author":"Quatromoni","year":"2012","journal-title":"J Transl Med"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1097-4652(199903)178:3<275::AID-JCP1>3.0.CO;2-Q","article-title":"Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages","volume":"178","author":"Chong","year":"1999","journal-title":"J Cell Physiol"},{"issue":"9","key":"10.6061\/clinics\/2018\/e549s_bib48","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm1093","article-title":"Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival","volume":"10","author":"Curiel","year":"2004","journal-title":"Nat Med"},{"issue":"11","key":"10.6061\/clinics\/2018\/e549s_bib49","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Murai","year":"2009","journal-title":"Nat Immunol"},{"key":"10.6061\/clinics\/2018\/e549s_bib50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2172-11-27","article-title":"Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth","volume":"11","author":"Bolpetti","year":"2010","journal-title":"BMC Immunol"},{"issue":"6","key":"10.6061\/clinics\/2018\/e549s_bib51","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.20082173","article-title":"Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1","volume":"206","author":"Kuang","year":"2009","journal-title":"J Exp Med"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib52","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1189\/jlb.1209821","article-title":"Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells","volume":"88","author":"Eruslanov","year":"2010","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib53","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4049\/jimmunol.1100889","article-title":"M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells","volume":"187","author":"Heusinkveld","year":"2011","journal-title":"J Immunol"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri2276","article-title":"Evolutionary struggles between NK cells and viruses","volume":"8","author":"Lanier","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.6061\/clinics\/2018\/e549s_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.smim.2006.03.002","article-title":"Surface NK receptors and their ligands on tumor cells","volume":"18","author":"Moretta","year":"2006","journal-title":"Semin Immunol"},{"issue":"10","key":"10.6061\/clinics\/2018\/e549s_bib56","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1002\/ijc.23733","article-title":"Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer","volume":"123","author":"Textor","year":"2008","journal-title":"Int J Cancer"},{"issue":"7","key":"10.6061\/clinics\/2018\/e549s_bib57","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1073\/pnas.92.7.2840","article-title":"Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells","volume":"92","author":"Woodworth","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ygyno.2008.01.008","article-title":"Cyclooxygenase-2 in cervical neoplasia: a review","volume":"109","author":"Young","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"7","key":"10.6061\/clinics\/2018\/e549s_bib59","first-page":"E319","article-title":"Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation","volume":"14","author":"Sappayatosok","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"11","key":"10.6061\/clinics\/2018\/e549s_bib60","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1158\/0008-5472.CAN-08-4695","article-title":"Nitric oxide induces early viral transcription coincident with increased DNA damage and mutation rates in human papillomavirus-infected cells","volume":"69","author":"Wei","year":"2009","journal-title":"Cancer Res"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ygyno.2008.09.017","article-title":"Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis","volume":"112","author":"Khunamornpong","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib62","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/carcin\/bgp066","article-title":"Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein","volume":"30","author":"Kim","year":"2009","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.6061\/clinics\/2018\/e549s_bib63","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1089\/jir.2009.0075","article-title":"Human papillomaviruses and the interferon response","volume":"29","author":"Beglin","year":"2009","journal-title":"J Interferon Cytokine Res"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib64","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/ijc.25442","article-title":"NF-\u03ba B-dependent upregulation of ICAM-1 by HPV16-E6\/E7 facilitates NK cell\/target cell interaction","volume":"128","author":"Textor","year":"2011","journal-title":"Int J Cancer"},{"issue":"1","key":"10.6061\/clinics\/2018\/e549s_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/mc.2940060103","article-title":"Differential effect of tumor necrosis factor on proliferation of primary human keratinocytes and cell lines containing human papillomavirus types 16 and 18","volume":"6","author":"Villa","year":"1992","journal-title":"Mol Carcinog"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.virol.2004.07.026","article-title":"HPV-18 confers resistance to TNF-alpha in organotypic cultures of human keratinocytes","volume":"328","author":"Boccardo","year":"2004","journal-title":"Virology"},{"key":"10.6061\/clinics\/2018\/e549s_bib67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1755-8794-1-29","article-title":"Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment","volume":"1","author":"Termini","year":"2008","journal-title":"BMC Med Genomics"},{"issue":"7","key":"10.6061\/clinics\/2018\/e549s_bib68","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/jcmm.12284","article-title":"HPV vaccine stimulates cytotoxic activity of killer dendritic cells and natural killer cells against HPV-positive tumour cells","volume":"18","author":"Van den Bergh","year":"2014","journal-title":"J Cell Mol Med"},{"issue":"4","key":"10.6061\/clinics\/2018\/e549s_bib69","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/21645515.2017.1407896","article-title":"Cellular immunogenicity of human papillomavirus vaccines Cervarix and Gardasil in adults with HIV infection","volume":"14","author":"Zurek Munk-Madsen","year":"2018","journal-title":"Hum Vaccin Immunother"},{"issue":"10","key":"10.6061\/clinics\/2018\/e549s_bib70","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4161\/hv.5.10.9518","article-title":"Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years","volume":"5","author":"Einstein","year":"2009","journal-title":"Hum Vaccin"},{"key":"10.6061\/clinics\/2018\/e549s_bib71","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/ijpvm.IJPVM_413_16","article-title":"Efficacy of Human Papillomavirus L1 Protein Vaccines (Cervarix and Gardasil) in Reducing the Risk of Cervical Intraepithelial Neoplasia: A Meta-analysis","volume":"8","author":"Haghshenas","year":"2017","journal-title":"Int J Prev Med"},{"issue":"11","key":"10.6061\/clinics\/2018\/e549s_bib72","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.4161\/hv.29275","article-title":"Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide","volume":"10","author":"Shen","year":"2014","journal-title":"Hum Vaccin Immunother"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib73","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.canep.2012.10.005","article-title":"Enhanced anti-tumor effects of HPV16E7(49-57)-based vaccine by combined immunization with poly(I:C) and oxygen-regulated protein 150","volume":"37","author":"Chen","year":"2013","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.6061\/clinics\/2018\/e549s_bib74","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/hum.2012.037","article-title":"Efficacy of DNA vaccines forming e7 recombinant retroviral virus-like particles for the treatment of human papillomavirus-induced cancers","volume":"24","author":"Lescaille","year":"2013","journal-title":"Hum Gene Ther"},{"issue":"8","key":"10.6061\/clinics\/2018\/e549s_bib75","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00705-014-2024-4","article-title":"Comparing the effect of Toll-like receptor agonist adjuvants on the efficiency of a DNA vaccine","volume":"159","author":"Sajadian","year":"2014","journal-title":"Arch Virol"},{"issue":"21","key":"10.6061\/clinics\/2018\/e549s_bib76","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1158\/1078-0432.CCR-14-0344","article-title":"Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFN\u03b3","volume":"20","author":"Soong","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.6061\/clinics\/2018\/e549s_bib77","doi-asserted-by":"crossref","first-page":"128","DOI":"10.7774\/cevr.2013.2.2.128","article-title":"Intranasal immunization with a flagellin-adjuvanted peptide anticancer vaccine prevents tumor development by enhancing specific cytotoxic T lymphocyte response in a mouse model","volume":"2","author":"Nguyen","year":"2013","journal-title":"Clin Exp Vaccine Res"},{"key":"10.6061\/clinics\/2018\/e549s_bib78","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biopha.2016.11.115","article-title":"Hp91 immunoadjuvant: An HMGB1-derived peptide for development of therapeutic HPVn vaccines","volume":"85","author":"Talebi","year":"2017","journal-title":"Biomed Pharmacother"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222011413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222011413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:01:03Z","timestamp":1761721263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222011413"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322018000200328&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/innate-immunity-and-hpv-friends-or-foes\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":78,"alternative-id":["S1807593222011413"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2018\/e549s","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innate immunity and HPV: friends or foes","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2018\/e549s","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e549s"}}