{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:32:06Z","timestamp":1761741126116,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":310,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2019]]},"DOI":"10.6061\/clinics\/2019\/e1205","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T15:32:06Z","timestamp":1572622326000},"page":"e1205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Clinical and Laboratory Parameters of Gonadotropin-Releasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2698-4461","authenticated-orcid":false,"given":"L\u00edvia Grimaldi Abud","family":"Fujita","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-8827","authenticated-orcid":false,"given":"Helo\u00edsa Marcelina da Cunha","family":"Palhares","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-9981","authenticated-orcid":false,"given":"Adriana Paula","family":"da Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-6895","authenticated-orcid":false,"given":"Jana\u00edne Machado","family":"Tom\u00e9","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-848X","authenticated-orcid":false,"given":"Maria de F\u00e1tima","family":"Borges","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"3","key":"10.6061\/clinics\/2019\/e1205_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/humupd\/7.3.292","article-title":"Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens","volume":"7","author":"Partsch","year":"2001","journal-title":"Hum Reprod Update"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1205_bib2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1542\/peds.2005-0012","article-title":"Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries","volume":"116","author":"Teilmann","year":"2005","journal-title":"Pediatrics"},{"issue":"12","key":"10.6061\/clinics\/2019\/e1205_bib3","first-page":"4583","article-title":"Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocius puberty: final height, body proportions, body composition, bone mineral density, and reproductive function","volume":"84","author":"Heger","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.6061\/clinics\/2019\/e1205_bib4","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1210\/jcem.86.10.7915","article-title":"Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience","volume":"86","author":"Klein","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1205_bib5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1515\/JPEM.2004.17.5.759","article-title":"Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs","volume":"17","author":"Lanes","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"12","key":"10.6061\/clinics\/2019\/e1205_bib6","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1097\/00004583-199712000-00026","article-title":"Is psychopathology associated with the timing of pubertal development?","volume":"36","author":"Graber","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1205_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1037\/0012-1649.39.3.430","article-title":"It\u2019s about timing and change: pubertal transition effects on symptoms of major depression among African American youths","volume":"39","author":"Ge","year":"2003","journal-title":"Dev Psychol"},{"key":"10.6061\/clinics\/2019\/e1205_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/1471-2458-9-446","article-title":"Early pubertal onset and its relationship with sexual risk taking, substance use and anti-social behaviour: a preliminary cross-sectional study","volume":"9","author":"Downing","year":"2009","journal-title":"BMC Public Health"},{"key":"10.6061\/clinics\/2019\/e1205_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-2458-10-175","article-title":"Factors associated with early menarche: results from the French Health Behaviour in School-aged Children (HBSC) study","volume":"10","author":"Gaudineau","year":"2010","journal-title":"BMC Public Health"},{"issue":"8","key":"10.6061\/clinics\/2019\/e1205_bib10","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1651-2227.2012.02707.x","article-title":"Subjective pubertal timing and health-compromising behaviours among Swiss adolescent girls reporting an on-time objective pubertal timing","volume":"101","author":"Deppen","year":"2012","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1205_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.yhbeh.2013.03.014","article-title":"Influences on the onset and tempo of puberty in human beings and implications for adolescent psychological development","volume":"64","author":"Lee","year":"2013","journal-title":"Horm Behav"},{"issue":"9","key":"10.6061\/clinics\/2019\/e1205_bib12","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1210\/jc.2003-031537","article-title":"A single luteinizing hormone determination 2 hours after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocius puberty in girls","volume":"89","author":"Brito","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.6061\/clinics\/2019\/e1205_bib13","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1210\/jc.2005-1500","article-title":"Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocius puberty","volume":"91","author":"Badaru","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.6061\/clinics\/2019\/e1205_bib14","first-page":"821","article-title":"[Effectiveness of Leuprolide acetate therapy every three months in central precocious puberty]","volume":"134","author":"Mericq","year":"2006","journal-title":"Rev Med Chil"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1205_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1687-9856-2011-7","article-title":"Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study","volume":"2011","author":"Lee","year":"2011","journal-title":"Int J Pediatr Endocrinol"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1205_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.6065\/apem.2013.18.4.173","article-title":"Multicenter clinical trial of leuprolide acetate depot (Luphere depot 3.75 mg) for efficacy and safety in girls with central precocious puberty","volume":"18","author":"Kim","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"6","key":"10.6061\/clinics\/2019\/e1205_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1590\/2359-3997000000101","article-title":"Evaluation of central precocious puberty treatment with GnRH analogue at the Triangulo Mineiro Federal University (UFTM)","volume":"59","author":"Borges","year":"2015","journal-title":"Arch Endocrinol Metab"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1205_bib18","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1210\/jc.2004-1863","article-title":"Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty","volume":"90","author":"Tanaka","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1205_bib19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1210\/jc.2007-1216","article-title":"Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function","volume":"93","author":"Pasquino","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.6061\/clinics\/2019\/e1205_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/1687-9856-2010-398639","article-title":"Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery","volume":"2010","author":"Neely","year":"2010","journal-title":"Int J Pediatr Endocrinol"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1205_bib21","doi-asserted-by":"crossref","first-page":"E30","DOI":"10.1542\/peds.109.2.e30","article-title":"Serum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy","volume":"109","author":"Bhatia","year":"2002","journal-title":"Pediatrics"},{"key":"10.6061\/clinics\/2019\/e1205_bib22","series-title":"Williams Textbook of Endocrinology","first-page":"1054","article-title":"Puberty: Ontogeny, neuroendocrinology, phisiology and disorders","author":"Styne","year":"2008"},{"issue":"235","key":"10.6061\/clinics\/2019\/e1205_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"10.6061\/clinics\/2019\/e1205_bib24","series-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist","first-page":"256","author":"Greulich","year":"1959"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1205_bib25","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1205_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1590\/S0004-27302008000100013","article-title":"Premature thelarche: clinical and laboratorial assessment by immunochemiluminescent assay","volume":"52","author":"Borges","year":"2008","journal-title":"Arq Bras Endocrinol Metab"},{"key":"10.6061\/clinics\/2019\/e1205_bib27","series-title":"Biostat\u00edstica - Te\u00f3rica e Computational","first-page":"423","author":"Arango","year":"2005"},{"issue":"2","key":"10.6061\/clinics\/2019\/e1205_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1515\/JPEM.2009.22.2.161","article-title":"Overnight luteinizing and follicle stimulating hormone profiles during GnRHa treatment in short girls born small for gestational age","volume":"22","author":"van der Kaay","year":"2009","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"10.6061\/clinics\/2019\/e1205_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2265.2011.04185.x","article-title":"Assessment of gonadotrophin suppression in girls treated with GnRH analogue for central precocious puberty; validity of single luteinizing hormone measurement after leuprolide acetate injection","volume":"76","author":"Demirbilek","year":"2012","journal-title":"Clin Endocrinol"},{"issue":"4","key":"10.6061\/clinics\/2019\/e1205_bib30","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"10.6061\/clinics\/2019\/e1205_bib31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jcem-67-3-474","article-title":"Premature thelarche and central precocious puberty: the relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone","volume":"67","author":"Pescovitz","year":"1988","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222007190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:53:17Z","timestamp":1761720797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222007190"},"secondary":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322019000100296&lng=en&nrm=iso&tlng=en","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6820513\/","label":"PMC"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/clinical-and-laboratory-parameters-of-gonadotropin-releasing-hormone-analog-treatment-effectiveness-in-children-with-precocious-puberty\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":31,"alternative-id":["S1807593222007190"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1205","relation":{},"ISSN":["1807-5932"],"issn-type":[{"type":"print","value":"1807-5932"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Laboratory Parameters of Gonadotropin-Releasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2019\/e1205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e1205"}}