{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:11:35Z","timestamp":1773144695968,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":254,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2020]]},"DOI":"10.6061\/clinics\/2020\/e1553","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T08:00:35Z","timestamp":1600761635000},"page":"e1553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Patterns of recurrence and outcomes of glioblastoma multiforme treated with chemoradiation and adjuvant temozolomide"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-3023","authenticated-orcid":false,"given":"Alexandre Ciuffi","family":"Faustino","sequence":"first","affiliation":[]},{"given":"Gustavo Arruda","family":"Viani","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4337-7575","authenticated-orcid":false,"given":"Ana Carolina","family":"Hamamura","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"10","key":"10.6061\/clinics\/2020\/e1553_bib1","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1002\/cam4.1757","article-title":"Trends and patterns of incidence of diffuse glioma in adults in the United States","volume":"7","author":"Li","year":"2018","journal-title":"Cancer Med"},{"issue":"2","key":"10.6061\/clinics\/2020\/e1553_bib2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJM200101113440207","article-title":"Brain Tumors","volume":"344","author":"DeAngelis","year":"2001","journal-title":"N Engl J Med"},{"issue":"10","key":"10.6061\/clinics\/2020\/e1553_bib3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"10.6061\/clinics\/2020\/e1553_bib4","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ijrobp.2006.05.021","article-title":"Phase II Radiation Therapy Oncology Group trial of conventional radiation therapy followed by treatment with recombinant interferon-beta for supratentorial glioblastoma: results of RTOG 9710","volume":"66","author":"Colman","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.6061\/clinics\/2020\/e1553_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.radonc.2015.12.003","article-title":"ESTRO-ACROP guideline \u201ctarget delineation of glioblastomas\u201d","volume":"118","author":"Niyazi","year":"2016","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.6061\/clinics\/2020\/e1553_bib6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.6061\/clinics\/2020\/e1553_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/030089160909500210","article-title":"Outcome of newly diagnosed glioblastoma patients treated by radiotherapy plus concomitant and adjuvant temozolomide: a long-term analysis","volume":"95","author":"Erpolat","year":"2009","journal-title":"Tumori"},{"issue":"8","key":"10.6061\/clinics\/2020\/e1553_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.clineuro.2009.06.013","article-title":"Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: single-center experience","volume":"111","author":"Jeon","year":"2009","journal-title":"Clin Neurol Neurosurg"},{"issue":"suppl_7","key":"10.6061\/clinics\/2020\/e1553_bib9","doi-asserted-by":"crossref","first-page":"vii6","DOI":"10.1093\/neuonc\/noy090","article-title":"Survivorship in adults with malignant brain and other central nervous system tumor from 2000-2014","volume":"20","author":"Gittleman","year":"2018","journal-title":"Neuro Oncol"},{"issue":"3","key":"10.6061\/clinics\/2020\/e1553_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11604-011-0031-x","article-title":"Recurrence patterns of glioblastoma treated with postoperative radiation therapy: relationship between extent of resection and progression-free interval","volume":"30","author":"Murakami","year":"2012","journal-title":"Jpn J Radiol"},{"key":"10.6061\/clinics\/2020\/e1553_bib11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1748-717X-9-130","article-title":"Patterns of failure for glioblastoma multiforme following limited-margin radiation and concurrent temozolomide","volume":"9","author":"Gebhardt","year":"2014","journal-title":"Radiat Oncol"},{"issue":"2","key":"10.6061\/clinics\/2020\/e1553_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11060-014-1500-8","article-title":"Combined salvage therapies for recurrent glioblastoma multiforme: evaluation of an interdisciplinary treatment algorithm","volume":"119","author":"Archavlis","year":"2014","journal-title":"J Neurooncol"},{"issue":"3","key":"10.6061\/clinics\/2020\/e1553_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/neuonc\/nop030","article-title":"Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma","volume":"12","author":"Kong","year":"2010","journal-title":"Neuro Oncol"},{"issue":"2","key":"10.6061\/clinics\/2020\/e1553_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11060-017-2731-2","article-title":"Outcomes after second surgery for recurrent glioblastoma: a retrospective case-control study","volume":"137","author":"Wann","year":"2018","journal-title":"J Neurooncol"},{"issue":"30","key":"10.6061\/clinics\/2020\/e1553_bib15","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1200\/JCO.2007.12.2440","article-title":"Bevacizumab plus irinotecan in recurrent glioblastoma multiforme","volume":"25","author":"Vredenburgh","year":"2007","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.6061\/clinics\/2020\/e1553_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1215\/15228517-2008-078","article-title":"New (alternative) temozolomide regimens for the treatment of glioma","volume":"11","author":"Wick","year":"2009","journal-title":"Neuro Oncol"},{"issue":"12","key":"10.6061\/clinics\/2020\/e1553_bib17","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1200\/JCO.2003.12.097","article-title":"Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study","volume":"21","author":"Jaeckle","year":"2003","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.6061\/clinics\/2020\/e1553_bib18","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1002\/cncr.23813","article-title":"Temozolomide rechallenge in recurrent malignant glioma by using a continuous temozolomide schedule: The \u201crescue\u201d approach","volume":"113","author":"Perry","year":"2008","journal-title":"Cancer"},{"key":"10.6061\/clinics\/2020\/e1553_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.critrevonc.2018.03.024","article-title":"Re-irradiation as salvage treatment in recurrent glioblastoma: A comprehensive literature review to provide practical answers to frequently asked questions","volume":"126","author":"Scoccianti","year":"2018","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222004628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222004628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:51:10Z","timestamp":1761720670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222004628"},"secondary":[{"URL":"https:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322020000100271&lng=en&nrm=iso&tlng=em","label":"SCIELO"},{"URL":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7470430\/","label":"PMC"},{"URL":"https:\/\/www.clinicsjournal.com\/article\/patterns-of-recurrence-and-outcomes-of-glioblastoma-multiforme-treated-with-chemoradiation-and-adjuvant-temozolomide\/","label":"CLINICS"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":19,"alternative-id":["S1807593222004628"],"URL":"https:\/\/doi.org\/10.6061\/clinics\/2020\/e1553","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of recurrence and outcomes of glioblastoma multiforme treated with chemoradiation and adjuvant temozolomide","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.6061\/clinics\/2020\/e1553","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 CLINICS. Published by Elsevier Spain","name":"copyright","label":"Copyright"}],"article-number":"e1553"}}