{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:21:31Z","timestamp":1791404491415,"version":"4.3.3"},"reference-count":162,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Alzheimer\u2019s disease is a progressive, neurodegenerative disease that represents a growing global health crisis. Two major forms of the disease exist: early onset (familial) and late onset (sporadic). Early onset Alzheimer\u2019s is rare, accounting for less than 5% of disease burden. It is inherited in Mendelian dominant fashion and is caused by mutations in three genes (<jats:italic>APP<\/jats:italic>,<jats:italic>PSEN1<\/jats:italic>, and<jats:italic>PSEN2<\/jats:italic>). Late onset Alzheimer\u2019s is common among individuals over 65 years of age. Heritability of this form of the disease is high (79%), but the etiology is driven by a combination of genetic and environmental factors. A large number of genes have been implicated in the development of late onset Alzheimer\u2019s. Examples that have been confirmed by multiple studies include<jats:italic>ABCA7<\/jats:italic>,<jats:italic>APOE<\/jats:italic>,<jats:italic>BIN1<\/jats:italic>,<jats:italic>CD2AP<\/jats:italic>,<jats:italic>CD33<\/jats:italic>,<jats:italic>CLU<\/jats:italic>,<jats:italic>CR1<\/jats:italic>,<jats:italic>EPHA1<\/jats:italic>,<jats:italic>MS4A4A\/MS4A4E\/MS4A6E<\/jats:italic>,<jats:italic>PICALM<\/jats:italic>, and<jats:italic>SORL1<\/jats:italic>. Despite tremendous progress over the past three decades, roughly half of the heritability for the late onset of the disease remains unidentified. Finding the remaining genetic factors that contribute to the development of late onset Alzheimer\u2019s disease holds the potential to provide novel targets for treatment and prevention, leading to the development of effective strategies to combat this devastating disease.<\/jats:p>","DOI":"10.6064\/2012\/246210","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T21:04:09Z","timestamp":1356987849000},"page":"1-14","source":"Crossref","is-referenced-by-count":67,"title":["The Genetics of Alzheimer\u2019s Disease"],"prefix":"10.6064","volume":"2012","author":[{"given":"Robert C.","family":"Barber","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, 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