{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:04:44Z","timestamp":1791439484366,"version":"4.3.3"},"reference-count":29,"publisher":"Korean Society of Pediatric Endocrinology","issue":"3","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Purpose: The gold standard for assessing pubertal activation is the gonadotropinreleasing hormone (GnRH) stimulation test (GnRHST), which is invasive, timeconsuming, and inconvenient. This study evaluated whether a single random measurement of urinary luteinizing hormone (LH) concentration could substitute for the GnRHST in diagnosing and monitoring central precocious puberty (CPP) in girls.Methods: Fifty-five girls with breast buds before 8 years of age were assessed by both the GnRHST and urinary gonadotropin assays. Based on the GnRHST results, 29 girls were assigned to the CPP group (peak LH\u22655 IU\/L), and 26 were placed in the premature thelarche (PT) group (peak LH&lt;5 IU\/L). Auxological data and urine and serum samples were collected at baseline and after treatment with a GnRH agonist for 12 and 24 weeks.Results: Although the auxological data did not differ between the 2 groups, the serum levels of insulin-like growth factor-1, basal LH, follicle-stimulating hormone (FSH), estradiol, and peak LH; urinary LH; and peak serum LH\/FSH and urinary LH\/FSH ratios were higher in the CPP group than in the PT group. Pearson correlation analysis showed a positive correlation between the urinary and serum LH concentrations (r=0.660, P&lt;0.001). Receiver-operating characteristic curve analyses showed that a urinary LH concentration of 0.725 IU\/L was a cutoff that significantly predicted positivity on the GnRHST. Urinary LH and FSH concentrations declined significantly during GnRH agonist treatment.Conclusion: A single, random measurement of urinary gonadotropin concentration could be a reliable tool for initial screening and therapeutic monitoring of CPP in girls.<\/jats:p>","DOI":"10.6065\/apem.2040208.104","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:22:17Z","timestamp":1620825737000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty"],"prefix":"10.6065","volume":"26","author":[{"given":"Se Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Myung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Mi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-5913","authenticated-orcid":true,"given":"Han Hyuk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0627-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2019.1575726"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000326625"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000440955"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0009922814541807"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.4.8636332"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2011.31.4.244"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2008.21.12.1113"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2012-10"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.242.478"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/eje-14-0010"},{"key":"ref13","volume-title":"","year":"2017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1180"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1569"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v3i1.03"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02692.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-015-1761-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-7-962"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/endo-77-6-1085"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1140"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143555"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/adc.40.209.16"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199612000-00013"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1690"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215580385"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.4.7714124"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002701"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000212"}],"container-title":["Annals of Pediatric Endocrinology &amp; 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