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The techniques used are described, with equal importance being given to each of the 3 approaches. Clinical skills are essential to elicit an accurate history, family pedigree, and symptoms of body system dysfunction. Endocrine assessment requires hormonal determination for the diagnosis of hormone deficiency and initiation of successful replacement therapy. Genetic analysis has added a new dimension to the investigation of short stature and now uses next-generation sequencing with a candidate gene approach to confirm probable recognizable monogenic disorders and exome sequencing for complex phenotypes of unknown origin. Using the 3 approaches of clinical, endocrine, and genetic probes with equal status in the hierarchy of investigational variables provides the clinician with the highest chance of identifying the correct causative pathogenetic mechanism in a child presenting with short stature of unknown origin.<\/jats:p>","DOI":"10.6065\/apem.2142208.104","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T06:57:39Z","timestamp":1640242659000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Balanced assessment of growth disorders using clinical, endocrinological, and genetic approaches"],"prefix":"10.6065","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-3376","authenticated-orcid":true,"given":"Martin Oswald","family":"Savage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen 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