{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:54:53Z","timestamp":1787032493150,"version":"build-2736575974"},"reference-count":40,"publisher":"Korean Society of Pediatric Endocrinology","issue":"1","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>Purpose: Hypoparathyroidism (hypoPTH) is the most common complication following thyroidectomy. We investigated the frequency and risk factors of hypoPTH after total thyroidectomy (TT) in pediatric patients with thyroid cancer.Methods: This retrospective study included 98 patients younger than 20 years who were diagnosed with thyroid cancer after T T during 1990\u20132018 and followed for more than 2 years at Seoul National University Hospital. HypoPTH was defined as receiving active vitamin D (1-hydroxycholecalciferol or 1,25-dihydroxycholecalciferol) after surgery.Results: The study included 27 boys (27.6%) and 71 girls (72.4%). The mean age at diagnosis was 14.9\u00b13.7 years. HypoPTH occurred in 43 patients (43.9%). Twenty-one patients (21.4%) discontinued active vitamin D less than 6 months after surgery, while 14 (14.3%) continued active vitamin D for more than 2 years. Tumor multifocality (odds ratio [OR], 3.7 vs. single tumor; &lt;i&gt;P&lt;\/i&gt;=0.013) and preoperative calcium level (OR, 0.2; &lt;i&gt;P&lt;\/i&gt;=0.028) were independent predictors of hypoPTH immediately after TT. In addition, age (OR, 0.8; &lt;i&gt;P&lt;\/i&gt;=0.011) and preoperative calcium level (OR, 0.04; &lt;i&gt;P&lt;\/i&gt;=0.014) significantly decreased the risk for persistent hypoPTH requiring active vitamin D for more than 2 years.Conclusion: HypoPTH occurred in 43.9% of pediatric thyroid cancer patients after TT in this study. Among them, one-third of patients continued active vitamin D medication for more than 2 years, which was predicted by young age and low preoperative calcium level.<\/jats:p>","DOI":"10.6065\/apem.2244044.022","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T08:32:28Z","timestamp":1656405148000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors of postoperative hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer"],"prefix":"10.6065","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-1676","authenticated-orcid":true,"given":"Yunsoo","family":"Choe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-2643","authenticated-orcid":true,"given":"Yun 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